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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 3AndIssue Number: 11AndStart Page: e205AndDate: 2007 Revise Search
- 1From: PLoS Genetics. (Vol. 3, Issue 11) Peer-ReviewedThe secondary structure of a pre-mRNA influences a number of processing steps including alternative splicing. Since most splicing regulatory proteins bind to single-stranded RNA, the sequestration of RNA into double...
- 2From: PLoS Genetics. (Vol. 3, Issue 11) Peer-ReviewedIn most eutherian mammals, sex chromosomes synapse and recombine during male meiosis in a small region called pseudoautosomal region. However in some species sex chromosomes do not synapse, and how these chromosomes...
- 3From: PLoS Genetics. (Vol. 3, Issue 11) Peer-ReviewedDuring cell division all chromosomes must be segregated accurately to each daughter cell. Errors in this process give rise to aneuploidy, which leads to birth defects and is implicated in cancer progression. The spindle...
- 4From: PLoS Genetics. (Vol. 3, Issue 11) Peer-ReviewedHigh serum uric acid levels elevate pro-inflammatory-state gout crystal arthropathy and place individuals at high risk for cardiovascular morbidity and mortality. Genome-wide scans in the genetically isolated Sardinian...
- 5From: PLoS Genetics. (Vol. 3, Issue 11) Peer-ReviewedApproximately 10% of genes in the human genome are distributed such that their transcription start sites are located less than 1 kb apart on opposite strands. These divergent gene pairs have a single intergenic segment...
- 6From: PLoS Genetics. (Vol. 3, Issue 11) Peer-ReviewedOne view of adaptation is that it proceeds by the slow and steady accumulation of beneficial mutations with small effects. It is difficult to test this model, since in most cases the genetic basis of adaptation can only...
- 7From: PLoS Genetics. (Vol. 3, Issue 11) Peer-ReviewedThe association of the major histocompatibility complex (MHC) with SLE is well established yet the causal variants arising from this region remain to be identified, largely due to inadequate study design and the strong...
- 8From: PLoS Genetics. (Vol. 3, Issue 11) Peer-ReviewedAlternative cassette exons are known to originate from two processes--exonization of intronic sequences and exon shuffling. Herein, we suggest an additional mechanism by which constitutively spliced exons become...
- 9From: PLoS Genetics. (Vol. 3, Issue 11) Peer-ReviewedWe present the AGEMAP (Atlas of Gene Expression in Mouse Aging Project) gene expression database, which is a resource that catalogs changes in gene expression as a function of age in mice. The AGEMAP database includes...
- 10From: PLoS Genetics. (Vol. 3, Issue 11) Peer-ReviewedTwo specific chromosome-targeting and gene regulatory systems are present in Drosophila melanogaster. The male X chromosome is targeted by the male-specific lethal complex believed to mediate the 2-fold up-regulation of...
- 11From: PLoS Genetics. (Vol. 3, Issue 11) Peer-ReviewedWhite coat color has been a highly valued trait in horses for at least 2,000 years. Dominant white (W) is one of several known depigmentation phenotypes in horses. It shows considerable phenotypic variation, ranging...
- 12From: PLoS Genetics. (Vol. 3, Issue 11) Peer-ReviewedDuring meiosis, self-inflicted DNA double-strand breaks (DSBs) are created by the protein Spo11 and repaired by homologous recombination leading to gene conversions and crossovers. Crossover formation is vital for the...
- 13From: PLoS Genetics. (Vol. 3, Issue 11) Peer-ReviewedChromosome inheritance during sexual reproduction relies on deliberate induction of double-strand DNA breaks (DSBs) and repair of a subset of these breaks as interhomolog crossovers (COs). Here we provide a direct...
- 14From: PLoS Genetics. (Vol. 3, Issue 11) Peer-ReviewedRecent genomic data indicate that RNA polymerase II (Pol II) function extends beyond conventional transcription of primarily protein-coding genes. Among the five snRNAs required for pre-mRNA splicing, only the U6 snRNA...
- 15From: PLoS Genetics. (Vol. 3, Issue 11) Peer-ReviewedComparison of whole genomes has revealed large and frequent changes in the size of gene families. These changes occur because of high rates of both gene gain (via duplication) and loss (via deletion or...
- 16From: PLoS Genetics. (Vol. 3, Issue 11) Peer-ReviewedThe distribution of transposable elements (TEs) in a genome reflects a balance between insertion rate and selection against new insertions. Understanding the distribution of TEs therefore provides insights into the...
- 17From: PLoS Genetics. (Vol. 3, Issue 11) Peer-ReviewedHypertension (HTN) is a devastating disease with a higher incidence in African Americans than European Americans, inspiring searches for genetic variants that contribute to this difference. We report the results of a...
- 18From: PLoS Genetics. (Vol. 3, Issue 11) Peer-ReviewedA novel candidate metastasis modifier, ribosomal RNA processing 1 homolog B (Rrp1b), was identified through two independent approaches. First, yeast two-hybrid, immunoprecipitation, and functional assays demonstrated a...
- 19From: PLoS Genetics. (Vol. 3, Issue 11) Peer-ReviewedA pandemic of metabolic diseases (atherosclerosis, diabetes mellitus, and obesity), unleashed by multiple social and economic factors beyond the control of most individuals, threatens to diminish human life span for the...
- 20From: PLoS Genetics. (Vol. 3, Issue 11) Peer-ReviewedWe examined genetic diversity and population structure in the American landmass using 678 autosomal microsatellite markers genotyped in 422 individuals representing 24 Native American populations sampled from North,...