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- 1From: PLoS Genetics. (Vol. 3, Issue 10) Peer-ReviewedDetailed studies of individual genes have shown that gene expression divergence often results from adaptive evolution of regulatory sequence. Genome-wide analyses, however, have yet to unite patterns of gene expression...
- 2From: PLoS Genetics. (Vol. 3, Issue 10) Peer-ReviewedDuring meiosis, homologous chromosomes recognize each other, align, and exchange genetic information. This process requires the action of RecA-related proteins Rad51 and Dmc1 to catalyze DNA strand exchanges. The...
- 3From: PLoS Genetics. (Vol. 3, Issue 10) Peer-ReviewedThe ability of human and murine APOBECs (specifically, APOBEC3) to inhibit infecting retroviruses and retrotransposition of some mobile elements is becoming established. Less clear is the effect that they have had on the...
- 4From: PLoS Genetics. (Vol. 3, Issue 10) Peer-ReviewedDrosophila provides a powerful system for defining the complex genetic programs that drive organogenesis. Under control of the steroid hormone ecdysone, the adult heart in Drosophila forms during metamorphosis by a...
- 5From: PLoS Genetics. (Vol. 3, Issue 10) Peer-ReviewedAutomated in situ hybridization enables the construction of comprehensive atlases of gene expression patterns in mammals. Such atlases can become Web-searchable digital expression maps of individual genes and thus offer...
- 6From: PLoS Genetics. (Vol. 3, Issue 10) Peer-ReviewedCryptococcus neoformans is a ubiquitous human fungal pathogen that causes meningoencephalitis in predominantly immunocompromised hosts. The fungus is typically haploid, and sexual reproduction involves two individuals...
- 7From: PLoS Genetics. (Vol. 3, Issue 10) Peer-ReviewedThe proopiomelanocortin gene (POMC) is expressed in the pituitary gland and the ventral hypothalamus of all jawed vertebrates, producing several bioactive peptides that function as peripheral hormones or central...
- 8From: PLoS Genetics. (Vol. 3, Issue 10) Peer-ReviewedA large number of alternative exons are spliced with tissue-specific patterns, but little is known about how such patterns have evolved. Here, we study the conservation of the neuron-specific splicing factors Nova1 and...
- 9From: PLoS Genetics. (Vol. 3, Issue 10) Peer-ReviewedWith more than 1.2 million copies, Alu elements are one of the most important sources of structural variation in primate genomes. Here, we compare the chimpanzee and human genomes to determine the extent of Alu...
- 10From: PLoS Genetics. (Vol. 3, Issue 10) Peer-ReviewedABSTRACT Genome-wide association scans (GWASs) using single nucleotide polymorphisms (SNPs) have been completed successfully for several common disorders and have detected over 30 new associations. Considering the...
- 11From: PLoS Genetics. (Vol. 3, Issue 10) Peer-ReviewedAutonomous chromosomes are generated in yeast (yeast artificial chromosomes) and human fibrosarcoma cells (human artificial chromosomes) by introducing purified DNA fragments that nucleate a kinetochore, replicate, and...
- 12From: PLoS Genetics. (Vol. 3, Issue 10) Peer-ReviewedTwo recently published papers describe nuclear DNA sequences that were obtained from the same Neanderthal fossil. Our reanalyses of the data from these studies show that they are not consistent with each other and point...
- 13From: PLoS Genetics. (Vol. 3, Issue 10) Peer-ReviewedPlants are continuously exposed to a myriad of abiotic and biotic stresses. However, the molecular mechanisms by which these stress signals are perceived and transduced are poorly understood. To begin to identify primary...
- 14From: PLoS Genetics. (Vol. 3, Issue 10) Peer-ReviewedZipper interacting protein kinase (ZIPK, also known as death-associated protein kinase 3 [DAPK3]) is a Ser/Thr kinase that functions in programmed cell death. Since its identification eight years ago, contradictory...
- 15From: PLoS Genetics. (Vol. 3, Issue 10) Peer-ReviewedIn many animal species, the sperm DNA is packaged with male germ line-specific chromosomal proteins, including protamines. At fertilization, these non-histone proteins are removed from the decondensing sperm nucleus and...
- 16From: PLoS Genetics. (Vol. 3, Issue 10) Peer-ReviewedAdvances in high-throughput genotyping and the International HapMap Project have enabled association studies at the whole-genome level. We have constructed whole-genome genotyping panels of over 550,000 (HumanHap550) and...
- 17From: PLoS Genetics. (Vol. 3, Issue 10) Peer-ReviewedThe female gametophyte of flowering plants, the embryo sac, develops within the diploid (sporophytic) tissue of the ovule. While embryo sac-expressed genes are known to be required at multiple stages of the fertilization...
- 18From: PLoS Genetics. (Vol. 3, Issue 10) Peer-ReviewedSpinocerebellar ataxia type-3 (SCA3) is among the most common dominantly inherited ataxias, and is one of nine devastating human neurodegenerative diseases caused by the expansion of a CAG repeat encoding glutamine...
- 19From: PLoS Genetics. (Vol. 3, Issue 10) Peer-ReviewedKidney function depends on the nephron, which comprises a blood filter, a tubule that is subdivided into functionally distinct segments, and a collecting duct. How these regions arise during development is poorly...
- 20From: PLoS Genetics. (Vol. 3, Issue 10) Peer-ReviewedThe role of CpG island methylation in normal development and cell differentiation is of keen interest, but remains poorly understood. We performed comprehensive DNA methylation profiling of promoter regions in normal...