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- 1From: Cell & Bioscience. (Vol. 3, Issue 1) Peer-ReviewedGerm line mutations in breast cancer gene 1 (BRCA1) predispose women to breast and ovarian cancers. Although BRCA1 is involved in many important biological processes, the function of BRCA1 in homologous recombination...
- 2From: Cell & Bioscience. (Vol. 3, Issue 1) Peer-ReviewedHemicentin has come a long way from when it was first identified in C. elegans as him-4 (High incidence of males). The protein is now a recognized player in maintaining the architectural integrity of vertebrate tissues...
- 3From: Cell & Bioscience. (Vol. 3, Issue 1) Peer-ReviewedBackground Mediating DNA damage-induced apoptosis is an important genome-maintenance function of the mismatch repair (MMR) system. Defects in MMR not only cause carcinogenesis, but also render cancer cells highly...
- 4From: Cell & Bioscience. (Vol. 3, Issue 1) Peer-ReviewedBackground There is an urgent need to develop targeted therapies for the control of advanced stage ovarian cancer because it is the most deadly gynecologic cancer. Antigen-specific immunotherapy is a promising...
- 5From: Cell & Bioscience. (Vol. 3, Issue 1) Peer-ReviewedBackground Merkel cell polyomavirus (MCPyV) is a DNA virus expressing transcripts similar to the large T (LT) and small T (ST) transcripts of SV40, which has been implicated in the pathogenesis of Merkel cell...
- 6From: Cell & Bioscience. (Vol. 3, Issue 1) Peer-ReviewedChina's new leadership has been on board recently and they will face a great challenge, how to control the spread of HIVAIDS in China. Recent studies have shown that sexual transmission has become the main route of HIV...
- 7From: Cell & Bioscience. (Vol. 3, Issue 1) Peer-ReviewedBackground Our previous research demonstrated that one subcutaneous injection of 17-Dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) 24 hours (h) before irradiation (8.75 Gy) increased mouse survival by...
- 8From: Cell & Bioscience. (Vol. 3, Issue 1) Peer-ReviewedAuthor(s): Dong-Yan Jin1 , Yun-Bo Shi2 and T-C Wu3 Talking about the golden era of the National Institutes of Health (NIH), Nobel laureates Joseph Goldstein and Michael Brown concluded in a recent issue of Science...
- 9From: Cell & Bioscience. (Vol. 3, Issue 1) Peer-ReviewedEpigenetic mechanisms are fundamental to understanding the regulatory networks ofgene expression that govern stem cell maintenance and differentiation. Methylated histone H3 lysine 4 (H3K4) has emerged as a key...
- 10From: Cell & Bioscience. (Vol. 3, Issue 1) Peer-ReviewedAutophagy serves as a dynamic degradation and recycling system that provides biological materials and energy in response to stress. The role of autophagy in tumor development is complex. Various studies suggest that...
- 11From: Cell & Bioscience. (Vol. 3, Issue 1) Peer-ReviewedBackground The previous investigation demonstrated the radioprotective efficacy of peptides isolated from the venom of Buthus Martti Karsch. In this study, the effect of isolated scorpion venom peptide II (SVPII) on...
- 12From: Cell & Bioscience. (Vol. 3, Issue 1) Peer-ReviewedAuthor(s): Dawang Zhou1 The Hippo pathway is recognized as an important regulator of tissue growth and cell fate [1-3]. Originally indentified in Drosophila, the Hippo pathway, also known as the Salvador-Warts-Hippo...
- 13From: Cell & Bioscience. (Vol. 3, Issue 1) Peer-ReviewedBackground Recent studies have suggested that a functional cure for HIV-1 infection, purportedly resultant from allogeneic bone marrow transplantation, may be possible. Additionally, the first such patient was...
- 14From: Cell & Bioscience. (Vol. 3, Issue 1) Peer-ReviewedBackground Type 1 and type 2 diabetes are characterized by loss of [beta]-cells; therefore, [beta]-cell regeneration has become one of the primary approaches to diabetes therapy. Resveratrol, a naturally occurring...
- 15From: Cell & Bioscience. (Vol. 3, Issue 1) Peer-ReviewedCell division in mitosis is tightly regulated via a group of protein kinases. Activation of these mitotic kinases is inhibited by the DNA damage checkpoint that arrests the cell cycle in interphase and prevents mitotic...
- 16From: Cell & Bioscience. (Vol. 3, Issue 1) Peer-ReviewedBackground Early endosomal autoantigen 1 (EEA1) is a membrane tethering factor required for the fusion and maturation of early endosomes in endocytosis. How the activity of EEA1 is regulated in cells is unclear....
- 17From: Cell & Bioscience. (Vol. 3, Issue 1) Peer-ReviewedBackground The nucleosome remodeling and histone deacetylase complex (Mi2/NRD/NuRD/NURD) has a broad role in regulation of transcription, DNA repair and cell cycle. Previous studies have revealed a specific...
- 18From: Cell & Bioscience. (Vol. 3, Issue 1) Peer-ReviewedContributing reviewers The editors of Cell & Bioscience would like to thank all the reviewers who contributed to the journal in Volume 2 (2012). Author(s): Yun-Bo Shi1 Christopher Allen United States of...
- 19From: Cell & Bioscience. (Vol. 3, Issue 1) Peer-ReviewedThe metazoan Hippo pathway is an essential tumour suppressor signalling cascade that ensures normal tissue growth by co-ordinating cell proliferation, cell death and cell differentiation. Over the past years, various...
- 20From: Cell & Bioscience. (Vol. 3, Issue 1) Peer-ReviewedThe mammalian intestine has long been used as a model to study organ-specific adult stem cells, which are essential for organ repair and tissue regeneration throughout adult life. The establishment of the intestinal...