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- 1From: BMC Medical Genomics. (Vol. 3) Peer-ReviewedBackground There is no cure for castration-recurrent prostate cancer (CRPC) and the mechanisms underlying this stage of the disease are unknown. Methods We analyzed the transcriptome of human LNCaP prostate...
- 2From: BMC Medical Genomics. (Vol. 3) Peer-ReviewedBackground Studies in mothers of Down syndrome individuals (MDS) point to a role for polymorphisms in folate metabolic genes in increasing chromosome damage and maternal risk for a Down syndrome (DS) pregnancy,...
- 3From: BMC Medical Genomics. (Vol. 3) Peer-ReviewedBackground Trisomic variants of human embryonic stem cells (hESCs) arise spontaneously in culture. Although trisomic hESCs share many properties with diploid hESCs, they also exhibit features of cancer stem cells....
- 4From: BMC Medical Genomics. (Vol. 3) Peer-ReviewedBackground Childhood leukemia is characterized by the presence of balanced chromosomal translocations or by other structural or numerical chromosomal changes. It is well know that leukemias with specific molecular...
- 5From: BMC Medical Genomics. (Vol. 3) Peer-ReviewedBackground Many common diseases arise from an interaction between environmental and genetic factors. Our knowledge regarding environment and gene interactions is growing, but frameworks to build an association...
- 6From: BMC Medical Genomics. (Vol. 3) Peer-ReviewedBackground Acute erythro- and megakaryoblastic leukaemias are associated with very poor prognoses and the mechanism of blastic transformation is insufficiently elucidated. The murine Graffi leukaemia retrovirus...
- 7From: BMC Medical Genomics. (Vol. 3) Peer-ReviewedBackground Arsenic is a known human carcinogen reported to cause chromosomal deletions and genetic anomalies in cultured cells. The vast human population inhabiting the Ganges delta in West Bengal, India and...
- 8From: BMC Medical Genomics. (Vol. 3) Peer-ReviewedBackground Chronic systemic low-grade inflammation in obese subjects is associated with health complications including cardiovascular diseases, insulin resistance and diabetes. Reducing inflammatory responses may...
- 9From: BMC Medical Genomics. (Vol. 3) Peer-ReviewedBackground Development in systems biology research has accelerated in recent years, and the reconstructions for molecular networks can provide a global view to enable in-depth investigation on numerous system...
- 10From: BMC Medical Genomics. (Vol. 3) Peer-ReviewedBackground The inability of aspirin (ASA) to adequately suppress platelet aggregation is associated with future risk of coronary artery disease (CAD). Heritability studies of agonist-induced platelet function...
- 11From: BMC Medical Genomics. (Vol. 3) Peer-ReviewedBackground The prevalence of diabetes is increasing worldwide. It has been long known that increased rates of inflammatory diseases, such as obesity (OBS), hypertension (HT) and cardiovascular diseases (CVD) are...
- 12From: BMC Medical Genomics. (Vol. 3) Peer-ReviewedBackground Cancer is a heterogeneous disease caused by genomic aberrations and characterized by significant variability in clinical outcomes and response to therapies. Several subtypes of common cancers have been...
- 13From: BMC Medical Genomics. (Vol. 3) Peer-ReviewedBackground According to the Genetic Analysis Workshops (GAW), hundreds of thousands of SNPs have been tested for association with rheumatoid arthritis. Traditional genome-wide association studies (GWAS) have been...
- 14From: BMC Medical Genomics. (Vol. 3) Peer-ReviewedBackground Tumor therapy mainly attacks the metabolism to interfere the tumor's anabolism and signaling of proliferative second messengers. However, the metabolic demands of different cancers are very heterogeneous...
- 15From: BMC Medical Genomics. (Vol. 3) Peer-ReviewedBackground The ultraconserved elements (UCEs) are defined as stretches of at least 200 base pairs of human DNA that match identically with corresponding regions in the mouse and rat genomes, albeit their real...
- 16From: BMC Medical Genomics. (Vol. 3) Peer-ReviewedBackground MUC1 protein is highly expressed in lung cancer. The cytoplasmic domain of MUC1 (MUC1-CD) induces tumorigenesis and resistance to DNA-damaging agents. We characterized MUC1-CD-induced transcriptional...
- 17From: BMC Medical Genomics. (Vol. 3) Peer-ReviewedBackground Genome-wide association studies give insight into the genetic basis of common diseases. An open question is whether the allele frequency distributions and ancestral vs. derived states of disease-associated...
- 18From: BMC Medical Genomics. (Vol. 3) Peer-ReviewedBackground The use of biological annotation such as genes and pathways in the analysis of gene expression data has aided the identification of genes for follow-up studies and suggested functional information to...
- 19From: BMC Medical Genomics. (Vol. 3) Peer-ReviewedBackground Decubitus ulcers, also known as bedsores or pressure ulcers, affect millions of hospitalized patients each year. The microflora of chronic wounds such as ulcers most commonly exist in the biofilm phenotype...
- 20From: BMC Medical Genomics. (Vol. 3) Peer-ReviewedBackground In translational cancer research, gene expression data is collected together with clinical data and genomic data arising from other chip based high throughput technologies. Software tools for the joint...