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- 1From: Oncogene. (Vol. 29, Issue 50) Peer-ReviewedTuberous sclerosis complex (TSC) is an autosomally inherited disorder that causes tumors to form in many organs. It is frequently caused by inactivating mutations in the TSC2 tumor-suppressor gene. TSC2 negatively...
- 2From: Oncogene. (Vol. 29, Issue 50) Peer-ReviewedIntegrin/cytokine receptor interaction provides permissive signals leading to neoangiogenesis, and integrins are crucial for differentiation of endothelial progenitor cells (EPCs). It is known that the inflammatory...
- 3From: Oncogene. (Vol. 29, Issue 50) Peer-ReviewedIn this study, we demonstrate that the expression in tumorigenic epidermal cells of a catalytically inactive form of CYLD ([CYLD.sup.C/S]) that mimics the identified mutations of cyld in human tumors and competes with...
- 4From: Oncogene. (Vol. 29, Issue 50) Peer-ReviewedC-terminal binding protein 1 (CtBP1) is a transcriptional co-repressor and metabolic sensory protein, which often represses tumor suppressor genes. Hence, we sought to determine if CtBP1 affects expression of the tumor...
- 5From: Oncogene. (Vol. 29, Issue 50) Peer-ReviewedCurrent mouse models do not reflect the sporadic nature of colon cancer and do not allow the analysis of antitumor immune response because of the lack of known tumor-specific antigens. Two transgenic mouse models with...
- 6From: Oncogene. (Vol. 29, Issue 50) Peer-ReviewedThe co-evolution of tumors and their microenvironment involves bidirectional communication between tumor cells and tumor-associated stroma. Various cell types are present in tumor-associated stroma, of which fibroblasts...
- 7From: Oncogene. (Vol. 29, Issue 50) Peer-ReviewedMicro RNAs are small non-coding RNAs, which regulate fundamental cellular and developmental processes at the transcriptional and translational level. In breast cancer, miR-145 expression is downregulated compared with...
- 8From: Oncogene. (Vol. 29, Issue 50) Peer-ReviewedIn this review, we discuss the role of the tumour-associated carbonic anhydrase isoform IX (CAIX) in the context of pH regulation. We summarise recent experimental findings on the effect of CAIX on cell growth and...
- 9From: Oncogene. (Vol. 29, Issue 50) Peer-ReviewedNew chemotherapy-enhancing strategies are needed for better cancer therapy. Previous studies suggest that exogenous cell-permeable C6 ceramide may be a useful adjunct to the anti-tumor effects of chemotherapeutic agents...