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- 1From: Oncogene. (Vol. 29, Issue 35) Peer-ReviewedResistance to chemotherapy in ovarian cancer is poorly understood. Evolutionary models of cancer predict that, following treatment, resistance emerges either because of outgrowth of an intrinsically resistant sub-clone...
- 2From: Oncogene. (Vol. 29, Issue 35) Peer-ReviewedProline oxidase (POX) is a novel mitochondrial tumor suppressor that can suppress proliferation and induce apoptosis through the generation of reactive oxygen species (ROS) and decreasing hypoxia-inducible factor (HIF)...
- 3From: Oncogene. (Vol. 29, Issue 35) Peer-ReviewedInhibition of isoprenylcysteine carboxylmethyltransferase (Icmt), which catalyzes the final step in the posttranslational C-terminal processing of prenylated proteins, suppresses tumor cell growth and induces cell...
- 4From: Oncogene. (Vol. 29, Issue 35) Peer-ReviewedThe Hedgehog (Hh) pathway regulates cell proliferation and survival and contributes to tumorigenesis. We investigated the expression and function of this pathway in B-cell chronic lymphocytic leukemia (CLL) cells and in...
- 5From: Oncogene. (Vol. 29, Issue 35) Peer-ReviewedOncogenic c-Myc has been described to modulate the expression of a subset of microRNAs (miRNAs), which include miR-22; however, the mechanism through which a miRNA controls c-Myc activity remains unclear. Here we report...
- 6From: Oncogene. (Vol. 29, Issue 35) Peer-ReviewedEpithelial-mesenchymal transition (EMT) has pivotal roles during embryonic development and carcinoma progression. Members of the Snai1 family of zinc finger transcription factors are central mediators of EMT and induce...
- 7From: Oncogene. (Vol. 29, Issue 35) Peer-ReviewedThe ubiquitin-proteasome system (UPS) is a multi-subunit pathway that allows for ubiquitin modification of proteins and leads to either degradation or other non-proteolytic processes such as trafficking or...
- 8From: Oncogene. (Vol. 29, Issue 35) Peer-Reviewed
MicroRNA-185 suppresses tumor growth and progression by targeting the Six1 oncogene in human cancers
Homeobox genes encode transcription factors that are essential for normal development and are often dysregulated in cancers. The molecular mechanisms that cause their misregulation in cancers are largely unknown. In... - 9From: Oncogene. (Vol. 29, Issue 35) Peer-ReviewedCell transformation by the v-rel oncogene is mediated by the aberrant expression of genes that are normally tightly regulated by other Rel/NF-[kappa]B family members. Although a number of genes inappropriately activated...
- 10From: Oncogene. (Vol. 29, Issue 35) Peer-ReviewedChemoresistance is a major cause of treatment failure and poor outcome in neuroblastoma. In this study, we investigated the expression and function of dual-specificity phosphatase 26 (DUSP26), also known as...
- 11From: Oncogene. (Vol. 29, Issue 35) Peer-ReviewedUpregulation of epidermal growth factor receptor (EGFR) and subsequent increases in extracellular-regulated kinase (ERK) and Akt signaling are implicated in prostate cancer progression. Impaired endocytic downregulation...
- 12From: Oncogene. (Vol. 29, Issue 35) Peer-ReviewedNicotinic acetylcholine receptors (nAChRs) are ligandgated ion channels that modulate key physiological processes ranging from neurotransmission to cancer signaling. These receptors are activated by the...