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- 1From: Oncogene. (Vol. 29, Issue 22) Peer-ReviewedThe cytoskeletal organization of detached and circulating tumor cells (CTCs) is currently not well defined and may provide potential targets for new therapies to limit metastatic tumor spread. In vivo, CTCs reattach in...
- 2From: Oncogene. (Vol. 29, Issue 22) Peer-ReviewedMdm2 binding protein (MTBP) has been implicated in cell-cycle arrest and the Mdm2/p53 tumor suppressor pathway through its interaction with Mdm2. To determine the function of MTBP in tumorigenesis and its potential role...
- 3From: Oncogene. (Vol. 29, Issue 22) Peer-ReviewedAs apoptosis defects limit efficacy of anticancer agents, autophagy has been proposed as a novel strategy for radiotherapy enhancement. We previously showed that caspase-3/7 inhibition induces autophagy and promotes...
- 4From: Oncogene. (Vol. 29, Issue 22) Peer-ReviewedBiologically active membrane gangliosides, expressed and released by many human tumors, are hypothesized to significantly impact tumor progression. Lack of a model of complete and specific tumor ganglioside depletion in...
- 5From: Oncogene. (Vol. 29, Issue 22) Peer-ReviewedWe have previously identified an oncogenic role of artemin (ARTN), a member of glial cell derived neurotrophic factor family of ligands, in mammary carcinoma. We herein report that ARTN is an estrogen-inducible gene....
- 6From: Oncogene. (Vol. 29, Issue 22) Peer-ReviewedThe use of c-abl-specific inhibitors such as Imatinib (IM) or Dasatinib has revolutionized the treatment of chronic myeloid leukemia (CML). However, a significant percentage of patients become resistant to IM. In this...
- 7From: Oncogene. (Vol. 29, Issue 22) Peer-ReviewedNovel therapeutic agents combined with innovative modes of delivery and non-invasive imaging of drug delivery, pharmacokinetics and efficacy are crucial in developing effective clinical anticancer therapies. In this...
- 8From: Oncogene. (Vol. 29, Issue 22) Peer-ReviewedHOP homeobox (HOPX) is an unusual homeobox gene encoding three spliced transcript variants, among which the only HOPX-[beta] promoter harbors CpG islands. The characteristics of its promoter methylation was analyzed...
- 9From: Oncogene. (Vol. 29, Issue 22) Peer-ReviewedT-box 2 (TBX2) is a transcription factor involved in mammary development and is known to be overexpressed in a subset of aggressive breast cancers. TBX2 has previously been shown to repress growth control genes such as...
- 10From: Oncogene. (Vol. 29, Issue 22) Peer-ReviewedApproximately 25% of childhood B-cell precursor acute lymphoblastic leukemia have an ETV6/RUNX1 (E/R) gene fusion that results from a t(12;21). This genetic subgroup of leukemia is associated with near-triploidy,...
- 11From: Oncogene. (Vol. 29, Issue 22) Peer-ReviewedActivation of androgen receptor (AR) may have a role in the development of castration-resistant prostate cancer. Two intracellular tyrosine kinases, Ack1 (activated cdc-42-associated kinase) and Src, phosphorylate and...
- 12From: Oncogene. (Vol. 29, Issue 22) Peer-ReviewedDasatinib, a dual Src family kinase and Abl inhibitor, is being tested clinically for the treatment of prostate cancer bone metastasis. Bidirectional interactions between osteoblasts and prostate cancer cells are...
- 13From: Oncogene. (Vol. 29, Issue 22) Peer-ReviewedOver the past decade, the reactivation of TWIST embryonic transcription factors has been described as a frequent event and a marker of poor prognosis in an impressive array of human cancers. Growing evidence now...