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- 1From: Oncogene. (Vol. 29, Issue 16) Peer-ReviewedAn oncogenic mutation (G49A:E17K) in the AKT1 gene has been described recently in human breast, colon, and ovarian cancers. The low frequency of this mutation and perhaps other selective pressures have prevented the...
- 2From: Oncogene. (Vol. 29, Issue 16) Peer-ReviewedGonadotropin-releasing hormone (GnRH) receptor expression is often elevated in ovarian cancer, but its potential role in ovarian cancer metastasis has just begun to be revealed. Cadherin switching is a crucial step...
- 3From: Oncogene. (Vol. 29, Issue 16) Peer-ReviewedAngiogenesis in glioblastoma is largely dependent on vascular endothelial growth factor (VEGF) signalling. Consistently, the VEGF coreceptor NRP1 promotes angiogenesis and tumour growth in gliomas. Here, we provide data...
- 4From: Oncogene. (Vol. 29, Issue 16) Peer-ReviewedWe earlier identified a lysine to arginine transition at residue 303 (K303R) in estrogen receptor alpha (ER[alpha])in invasive breast cancers, which confers resistance to the aromatase inhibitor (AI) anastrozole (Ana)...
- 5From: Oncogene. (Vol. 29, Issue 16) Peer-ReviewedThe p53 tumor suppressor protein is frequently mutated in human tumors. It is thought that the p53 pathway is indirectly impaired in the remaining tumors, for example by overexpression of its important regulators Mdm2...
- 6From: Oncogene. (Vol. 29, Issue 16) Peer-ReviewedThe pRb tumour suppressor protein has a central role in coordinating early cell cycle progression. An important level of control imposed on pRb occurs through posttranslational modification, for example,...
- 7From: Oncogene. (Vol. 29, Issue 16) Peer-ReviewedHepatocellular carcinoma (HCC) is the fifth most common cancer and the third leading cause of cancer death worldwide. Despite recent advances in the diagnosis and treatment of HCC, its prognosis remains dismal....
- 8From: Oncogene. (Vol. 29, Issue 16) Peer-ReviewedCutaneous malignant melanoma is considered one of the most deadly human cancers, based on both its penchant for metastatic spread and its typical resistance to currently available therapy. Long known to harbor oncogenic...
- 9From: Oncogene. (Vol. 29, Issue 16) Peer-ReviewedInvasive cell migration is a key step for cancer metastasis and involves Rho GTPase-controlled reorganization of the actin cytoskeleton. Altered Rho GTPase expression is found in various malignancies. Particularly, the...
- 10From: Oncogene. (Vol. 29, Issue 16) Peer-ReviewedDysregulated cell cycling is a universal hallmark of cancer and is often mediated by abnormal activation of cyclin-dependent kinases (CDKs) and their cyclin partners. Over-expression of individual complexes are reported...
- 11From: Oncogene. (Vol. 29, Issue 16) Peer-ReviewedWe have previously performed an unbiased screen to identify genes whose expression is associated with the metastatic phenotype. Secondary screening of these genes using custom microarray chips identified ASAP1, a...
- 12From: Oncogene. (Vol. 29, Issue 16) Peer-ReviewedMatrix remodeling, degradation, inflammation and invasion liberate peptide fragments that can subsequently interact with cells in an attachment-independent manner. Such 'soluble' matrix components, including collagens,...
- 13From: Oncogene. (Vol. 29, Issue 16) Peer-ReviewedEpidermal growth factor receptor (EGFR) tyrosine kinase inhibitors, gefitinib and erlotinib are effective therapies against mutant non-small cell lung cancers (NSCLCs). Treatment is limited by the development of...