Showing Results for
- Academic Journals (13)
Search Results
- 13
Academic Journals
- 13
- Search Terms:
- 1From: Oncogene. (Vol. 29, Issue 10) Peer-ReviewedThe adenomatous polyposis coli (APC) gene is mutated in familial adenomatous polyposis. Mice with a heterozygous [APC.sup.Min] mutation develop multiple intestinal neoplasia (Min) leading to premature death. Early in...
- 2From: Oncogene. (Vol. 29, Issue 10) Peer-ReviewedMutational analysis of oncogenes is critical for our understanding of cancer development. Oncogenome screening has identified a fibroblast growth factor receptor 4 (FGFR4) Y367C mutation in the human breast cancer cell...
- 3From: Oncogene. (Vol. 29, Issue 10) Peer-ReviewedThe p53-inducible gene 3 (PIG3) is originally isolated as a p53 downstream target gene, but its function remains unknown. Here, we report a role of PIG3 in the activation of DNA damage checkpoints, after UV irradiation...
- 4From: Oncogene. (Vol. 29, Issue 10) Peer-ReviewedNotch3 and pT[alpha] signaling events are essential for T-cell leukemogenesis and characterize murine and human T-cell acute lymphoblastic leukemia. Genetic ablation of pT[alpha] expression in Notch3 transgenic mice...
- 5From: Oncogene. (Vol. 29, Issue 10) Peer-ReviewedThe inhibitor of growth family member 3 (ING3) has been shown to modulate transcription, cell cycle control and apoptosis. We previously reported that nuclear ING3 expression was remarkably reduced in melanomas, which...
- 6From: Oncogene. (Vol. 29, Issue 10) Peer-ReviewedEstrogen receptor-[alpha] (ER[alpha]) is a major therapeutic target of hormonal therapies in breast cancer, and its expression in tumors is predictive of clinical response. Protein levels of ER[alpha] are tightly...
- 7From: Oncogene. (Vol. 29, Issue 10) Peer-ReviewedWerner's syndrome (WS) is a rare autosomal disease characterized by the premature onset of several age-associated pathologies. The protein defective in patients with WS (WRN) is a helicase/exonuclease involved in DNA...
- 8From: Oncogene. (Vol. 29, Issue 10) Peer-ReviewedThe appropriate response of human keratinocytes to ultraviolet-B (UVB) is dependent on the activation status of the insulin-like growth factor 1 (IGF-1) receptor. Keratinocytes grown in conditions in which the IGF-1...
- 9From: Oncogene. (Vol. 29, Issue 10) Peer-ReviewedThe forced overexpression of c-Myc in mouse prostate and in normal human prostate epithelial cells results in tumor transformation with an invasive phenotype. How c-Myc regulates cell invasion is poorly understood. In...
- 10From: Oncogene. (Vol. 29, Issue 10) Peer-ReviewedDNA amplifications, leading to the overexpression of oncogenes, are a cardinal feature of lung cancer and directly contribute to its pathogenesis. To uncover such novel alterations, we performed an array-based...
- 11From: Oncogene. (Vol. 29, Issue 10) Peer-ReviewedThe ER[alpha] signaling pathway is one of the most important and most studied pathways in human breast cancer, yet numerous questions still exist such as how hormonally responsive cancers progress to a more aggressive...
- 12From: Oncogene. (Vol. 29, Issue 10) Peer-ReviewedThe Ras oncogene is known to activate three major MAPK pathways, ERK, JNK, p38 and exert distinct cellular phenotypes, that is, apoptosis and invasion through the Ras-MKK3-p38-signaling cascade. We attempted to identify...
- 13From: Oncogene. (Vol. 29, Issue 10) Peer-ReviewedViruses are associated with 15-20% of human cancers worldwide. In the last century, many studies were directed towards elucidating the molecular mechanisms and genetic alterations by which viruses cause cancer. The...