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- 1From: Journal of Experimental & Clinical Cancer Research. (Vol. 29) Peer-ReviewedBackground Anti-CD20 monoclonal antibody treatment has not only increased survival and cure rates in many non-Hodgkin lymphomas, but also has prompted an explosion in the development of novel antibodies and...
- 2From: Journal of Experimental & Clinical Cancer Research. (Vol. 29) Peer-ReviewedBackground Glucocorticoid (GC) resistance is frequently seen in acute lymphoblastic leukemia of T-cell lineage (T-ALL). In this study we investigate the potential and mechanism of using rapamycin to restore the...
- 3From: Journal of Experimental & Clinical Cancer Research. (Vol. 29) Peer-ReviewedAuthors: Ondrej Slaby (corresponding author) [1,3]; Jana Jancovicova [4]; Radek Lakomy [1]; Marek Svoboda [1]; Alexandr Poprach [1]; Pavel Fabian [2]; Leos Kren [5]; Jaroslav Michalek [3]; Rostislav Vyzula [1]...
- 4From: Journal of Experimental & Clinical Cancer Research. (Vol. 29) Peer-ReviewedBackground To compare the biological characteristics of three types of human hepatocellular carcinoma multi-drug resistant cell sub-lines Bel-7402/ADM models established by three methods. Methods Established...
- 5From: Journal of Experimental & Clinical Cancer Research. (Vol. 29) Peer-ReviewedBackground This study was conducted to identify a recommended dose for S-1, used in combination with 40-Gy radiation. Methods Thirty patients, 15 each with stage III and IVA oral carcinoma, were enrolled. All...
- 6From: Journal of Experimental & Clinical Cancer Research. (Vol. 29) Peer-ReviewedObjectives To explore the function of p38MAPK and caspase-3 in DADS-induced apoptosis in human HepG2 cells, and discuss the signal transduetion mechanism of HepG2 cells in the apoptosis process induced by DADS by...
- 7From: Journal of Experimental & Clinical Cancer Research. (Vol. 29) Peer-ReviewedBackground In spite of recent advances in diagnostic and therapeutic measures, the prognosis of hepatocellular carcinoma (HCC) patients remains poor. Therefore, it is crucial to understand what factors are involved...
- 8From: Journal of Experimental & Clinical Cancer Research. (Vol. 29) Peer-ReviewedBackground Survivin is known playing a role in drug resistance. However, its role in bortezomib-mediated inhibition of growth and induction of apoptosis is unclear. There are conflicting reports for the effect of...
- 9From: Journal of Experimental & Clinical Cancer Research. (Vol. 29) Peer-ReviewedBackground Breast cancer stem cells (BCSCs) have been recently identified in breast carcinoma as CD44.sup.+.sup.CD24.sup.- .sup.cells, which exclusively retain tumorigenic activity and display stem cell-like...
- 10From: Journal of Experimental & Clinical Cancer Research. (Vol. 29) Peer-ReviewedBackground To investigate whether dendritic cell (DC) precursors, recruited by injection of chemokine ligand 3 (CCL3) and CCL20, induce anti-tumor immunity against gastric cancer induced by a DC vaccine expressing...
- 11From: Journal of Experimental & Clinical Cancer Research. (Vol. 29) Peer-ReviewedBackground The present report was designed to investigate the origins of elevated oxidative stress measured in cancer patients in our previous work related to a case-control study (17 cases, 43 controls) on...
- 12From: Journal of Experimental & Clinical Cancer Research. (Vol. 29) Peer-ReviewedPatients with cervical carcinoma (CC) are frequently immunocompromised. Dendritic cells (DCs) are potent antigen-presenting cells. Using multicolor flow cytometry, the percentages of CD11c+ (DC1) and CD123+ (DC2)...
- 13From: Journal of Experimental & Clinical Cancer Research. (Vol. 29) Peer-ReviewedBackground MUC5AC is a secretory mucin normally expressed in the surface muconous cells of stomach and bronchial tract. It has been known that MUC5AC de novo expression occurred in the invasive ductal carcinoma and...
- 14From: Journal of Experimental & Clinical Cancer Research. (Vol. 29) Peer-ReviewedBackground Endometriosis is a common disease characterized by the presence of a functional endometrium outside the uterine cavity, causing pelvic pain, dysmenorrheal, and infertility. This disease has been associated...
- 15From: Journal of Experimental & Clinical Cancer Research. (Vol. 29) Peer-ReviewedBackground The diagnosis of lymph node metastasis in esophageal cancer by the presence and number of metastatic lymph nodes is an extremely important prognostic factor. In addition, the indication of non-surgical...
- 16From: Journal of Experimental & Clinical Cancer Research. (Vol. 29) Peer-ReviewedBackground Perineural invasion is a common path for cholangiocarcinoma (CCA) metastasis, and it is highly correlated with postoperative recurrence and poor prognosis. It is often an early event in a disease that is...
- 17From: Journal of Experimental & Clinical Cancer Research. (Vol. 29) Peer-ReviewedBackground Thymoquinone (TQ) is a compound extracted from Black Caraway seeds of Nigella Sativa and is active against various cancers. Cisplatin (CDDP) is the most active chemotherapeutic agent in Lung Cancer. Here...
- 18From: Journal of Experimental & Clinical Cancer Research. (Vol. 29, Issue 175) Peer-ReviewedBackground This study aimed to determine the miRNA profile in breast cancer stem cells (BCSCs) and to explore the functions of characteristic BCSC miRNAs. Methods We isolated ESA.sup.+CD44.sup.+CD24.sup.-/low...
- 19From: Journal of Experimental & Clinical Cancer Research. (Vol. 29) Peer-ReviewedBackground This study was conducted to investigate the expression of CXCR4 in portal vein tumor thrombus (PVTT) tissue and its possible role in the invasiveness of tumor thrombus cells. Methods We detected...
- 20From: Journal of Experimental & Clinical Cancer Research. (Vol. 29) Peer-ReviewedBackground Various strains of Bacillus thuringiensis (Bt) have been found to produce parasporal proteins that are cytotoxic to human cancer cells. This study aims to establish the binding affinity of purified Bt 18...