Showing Results for
- Academic Journals (14)
Search Results
- 14
Academic Journals
- 14
- Search Terms:
- 1From: Oncogene. (Vol. 28, Issue 5) Peer-Reviewed[O.sup.6]-methylguanine DNA methyltransferase (MGMT) suppresses mutations and cell death that result from alkylation damage. MGMT expression is lost by epigenetic silencing in a variety of human cancers including nearly...
- 2From: Oncogene. (Vol. 28, Issue 5) Peer-ReviewedThe biological and clinical heterogeneity of neuroblastoma is closely associated with signaling pathways that control cellular characteristics such as proliferation, survival and differentiation. The Shc family of...
- 3From: Oncogene. (Vol. 28, Issue 5) Peer-ReviewedA defining feature of basal-like breast cancer, a breast cancer subtype with poor clinical prognosis, is the high expression of 'proliferation signature' genes. We identified B-Myb, a MYB family transcription factor that...
- 4From: Oncogene. (Vol. 28, Issue 5) Peer-ReviewedThere is emerging evidence that the oncogenic potential of hdm2 (human and/or murine double minute-2 protein) stems not only from its ability to counteract tumor suppressor p53 but also from its less understood...
- 5From: Oncogene. (Vol. 28, Issue 5) Peer-ReviewedThe promyelocytic leukemia (PML) tumor suppressor protein, a central regulator of cell proliferation and apoptosis, is frequently fused to the retinoic acid receptor-α (RARα) in acute PML. Here we show the interaction of...
- 6From: Oncogene. (Vol. 28, Issue 5) Peer-ReviewedIn human hepatocellular carcinoma (HCC), epithelial to mesenchymal transition (EMT) correlates with aggressiveness of tumors and poor survival. We employed a model of EMT based on immortalized [p19.sup.ARF] null...
- 7From: Oncogene. (Vol. 28, Issue 5) Peer-ReviewedFanconi anemia (FA) is a recessive genome instability syndrome characterized by heightened cellular sensitivity to DNA damage, aplastic anemia and cancer susceptibility. Leukemias and squamous cell carcinomas ("CCs) are...
- 8From: Oncogene. (Vol. 28, Issue 5) Peer-ReviewedRecent studies have demonstrated essential functions for KIF3, a microtubule-directed protein motor, in subcellular transport of several cancer-related proteins, including the β-catenin-cadherin(s) complex. In this...
- 9From: Oncogene. (Vol. 28, Issue 5) Peer-ReviewedHigh-risk mucosal human papillomaviruses (HPV), mainly HPV16 and HPV18, are implicated in cervical carcinogenesis. HPV16 E6 oncoprotein binds and often targets for degradation numerous cell proteins, including the tumor...
- 10From: Oncogene. (Vol. 28, Issue 5) Peer-ReviewedHere, we show that FoxO3A transcription factor is upregulated upon calpain small-1 (CAPNS1) depletion both in mouse embryonic fibroblasts (MEFs) and in the human mammary carcinoma cell line MCF-7. On starvation, CAPNS1...
- 11From: Oncogene. (Vol. 28, Issue 5) Peer-ReviewedUsing mass spectrometric analysis insulin receptor substrate 4 (IRS-4) has been identified as a novel adenovirus 5 early region IA (Ad5EIA)-binding protein. IRS-4 interacts with both the transcriptional activation domain...
- 12From: Oncogene. (Vol. 28, Issue 5) Peer-ReviewedHIC1 is a newly discovered tumor suppressor and transcriptional repressor that is frequently silenced in human tumors. HIC1 protein expression has been linked to better outcomes in breast cancers. The molecular mechanism...
- 13From: Oncogene. (Vol. 28, Issue 5) Peer-ReviewedHedgehog signaling is often activated in tumors, yet it remains unclear how GLI2, a transcription factor activated by this pathway, acts as an oncogene. We show that GLI2 is a pleiotropic oncogene. The overexpression...
- 14From: Oncogene. (Vol. 28, Issue 5) Peer-ReviewedThe receptor for macrophage colony-stimulating factor 1 receptor (CSF1R) is a product of the proto-oncogene c-fms and a member of the class III transmembrane tyrosine kinase receptor family. Earlier, we described...