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- 1From: Oncogene. (Vol. 28, Issue 3) Peer-ReviewedOverexpression of epidermal growth factor receptor (EGFR) is associated with enhanced activation of wild-type (hyperactive) Ras in breast cancer. Little is known about the regulation of Ras inactivation and...
- 2From: Oncogene. (Vol. 28, Issue 3) Peer-ReviewedThree-dimensional (3D) cell culture techniques are frequently used to model alterations in tissue architecture critically important for tumor development. Here, we report on a detailed comparison of a spheroid model of...
- 3From: Oncogene. (Vol. 28, Issue 3) Peer-Reviewed11q13 amplification is a late-stage event in several cancers that is often associated with poor prognosis. Among 11q13-amplified genes, the actin assembly protein cortactin/CTTN is considered a likely candidate for...
- 4From: Oncogene. (Vol. 28, Issue 3) Peer-ReviewedThe hypoxia-inducible factor 1 (HIF-1) plays a critical role for tumour adaptation to microenvironmental hypoxia, and represents an appealing chemotherapeutic target. Silibinin is a nontoxic flavonoid reported to exhibit...
- 5From: Oncogene. (Vol. 28, Issue 3) Peer-ReviewedEukaryoticc ells respond to genotoxic stress by inducing cell growth arrest or apoptosis. Although the p53 tumor suppressor largely contributes to the response by regulating antiproliferative or pro-apoptotic genes, some...
- 6From: Oncogene. (Vol. 28, Issue 3) Peer-ReviewedBone resorption by osteoclasts is thought to promote the proliferation of prostate cancer cells disseminated to the skeleton (Mundy, 2002). Using a mouse model of experimental metastasis, we found that although...
- 7From: Oncogene. (Vol. 28, Issue 3) Peer-ReviewedThe human adenovirus E4orf4 protein, when expressed alone, induces p53-independent death in a wide range of cancer cells. Earlier studies by our groups suggested that although in some cases cell death can be associated...
- 8From: Oncogene. (Vol. 28, Issue 3) Peer-ReviewedEffective treatment of malignant melanoma with the tumor-selective death ligand tumor necrosis-related apoptosis-inducing ligand (TRAIL) is curtailed by the fact that many melanoma cell lines are a priori resistant...
- 9From: Oncogene. (Vol. 28, Issue 3) Peer-ReviewedSequestosome 1 (SQSTM1/p62) is a multifunctional protein involved in signal transduction, protein degradation and cell transformation. Hypoxia is a common feature of solid tumours that promotes cancer progression. Here,...
- 10From: Oncogene. (Vol. 28, Issue 3) Peer-ReviewedThe tumor suppressor p53 regulates downstream genes in response to many cellular stresses and is frequently mutated in human cancers. Here, we report the use of a crosslinking strategy to trap a tetrameric p53...
- 11From: Oncogene. (Vol. 28, Issue 3) Peer-ReviewedMyc and transforming growth factor-β (TGFβ) signaling are mutually antagonistic, that is Myc suppresses the activation of TGFβ-induced genes, whereas TGFβ represses c-myc transcription. Here, we report a positive role...
- 12From: Oncogene. (Vol. 28, Issue 3) Peer-ReviewedBrain tumors are associated with genetic alterations of oncogenes and tumor suppressor genes. Accumulation of reactive oxygen species (ROS) in cells leads to oxidative stress-induced damage, resulting in tumorigenesis....
- 13From: Oncogene. (Vol. 28, Issue 3) Peer-ReviewedCortactin binds F-actin and promotes cell migration. We showed earlier that cortactin is acetylated. Here, we identify SIRT1 (a class III histone deacetylase) as a cortactin deacetylase and p300 as a cortactin acetylase....