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- 1From: Oncogene. (Vol. 27, Issue 48) Peer-ReviewedThe NF-κB signaling pathway has particular relevance to several liver diseases including hepatitis (liver infection by Helicobacter, viral hepatitis induced by HBV and HCV), liver fibrosis and cirrhosis and...
- 2From: Oncogene. (Vol. 27, Issue 48) Peer-ReviewedThe demonstration of protein sequence and functional homology of the Caenorhabditis elegans programmed cell death gene product, CED-3, with human caspase-1 in 1993 triggered an explosion of research activities toward the...
- 3From: Oncogene. (Vol. 27, Issue 48) Peer-ReviewedDeath effector domains (DEDs) are protein interaction modules found in a number of proteins known to regulate apoptosis from death receptors. The core DED family members that orchestrate programmed cell death from death...
- 4From: Oncogene. (Vol. 27, Issue 48) Peer-ReviewedDNA damage, chromosomal abnormalities, oncogene activation, viral infection, substrate detachment and hypoxia can all trigger apoptosis in normal cells. However, cancer cells acquire mutations that allow them to survive...
- 5From: Oncogene. (Vol. 27, Issue 48) Peer-ReviewedThe promyelocytic leukemia protein (PML) is a tumor suppressor identified in acute PML and implicated in the pathogenesis of a variety of tumors. PML is essential for the proper assembly of a nuclear macromolecular...
- 6From: Oncogene. (Vol. 27, Issue 48) Peer-ReviewedA little over 10 years after its discovery in 1997, the small inhibitor of apoptosis (IAP) protein, survivin, continues to generate intense interest and keen attention from disparate segments of basic and disease-related...
- 7From: Oncogene. (Vol. 27, Issue 48) Peer-ReviewedTo tumor biologists, defective apoptosis is recognized as one of the six pillars upon which cancer occurs and progresses, along with defective cell-cycle regulation, growth factor autonomy, overcoming senescence,...
- 8From: Oncogene. (Vol. 27, Issue 48) Peer-ReviewedJun N-terminal kinases or JNKs play a critical role in death receptor-initiated extrinsic as well as mitochondrial intrinsic apoptotic pathways. JNKs activate apoptotic signaling by the upregulation of pro-apoptotic...
- 9From: Oncogene. (Vol. 27, Issue 48) Peer-ReviewedJohn C Reed, MD, PhD, is a leader in apoptosis and cell death research, working at the Burnham Institute for Medical Research, where he currently serves as President and Chief Executive Officer and as the Donald Bren...
- 10From: Oncogene. (Vol. 27, Issue 48) Peer-ReviewedThe extracellular matrix (ECM) acts both as a physical scaffold for cells and as a repository for growth factors. Moreover, ECM structure and physical--chemical properties convey precise information to cells that...
- 11From: Oncogene. (Vol. 27, Issue 48) Peer-ReviewedTumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily and has been shown to induce apoptosis in cancer cells but not normal cells. TRAIL triggers apoptosis through...