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- 1From: Oncogene. (Vol. 27, Issue 32) Peer-ReviewedAberrant activation of the Wnt/β-catenin signaling pathway is a hallmark of colon cancer. We show that the Wnt antagonist DICKKOPF-4 (DKK-4) gene is repressed by lα,25-dihydroxyvitamin [D.sub.3]...
- 2From: Oncogene. (Vol. 27, Issue 32) Peer-ReviewedPromoter methylation of the RAS-association domain family 1, isoform A gene (RASSF1A) is one of the most frequent events found in human tumours. In this study we set out to test the hypothesis that loss of Rassf1a can...
- 3From: Oncogene. (Vol. 27, Issue 32) Peer-ReviewedAndrogen-withdrawal-induced apoptosis (AWIA) is deregulated in androgen refractory prostate cancer. Androgens have been shown to positively regulate expression of the antiapoptotic FADD-like interleukin-1β-converting...
- 4From: Oncogene. (Vol. 27, Issue 32) Peer-Reviewedβ-catenin accumulation is often found in lung tumors, but only a few patients have mutations in β-catenin gene. In addition, activated p53 downregulates β-catenin. Therefore, we postulated that alteration of the...
- 5From: Oncogene. (Vol. 27, Issue 32) Peer-ReviewedFbw7 is a tumor suppressor that is mutated in numerous cancers. It encodes an E3 ubiquitin ligase, whose ability to decrease the levels of pivotal regulators of cell growth and proliferation underlies its tumor...
- 6From: Oncogene. (Vol. 27, Issue 32) Peer-ReviewedExtensive mutational/functional analysis of the transcription-repression domain encoded in the N-terminal 80 amino acids of the adenovirus E1A 243R oncoprotein suggests a model for the molecular mechanism of E1A...
- 7From: Oncogene. (Vol. 27, Issue 32) Peer-ReviewedPrimitive neuroectodermal tumors (PNETs) are a family of primary malignant brain tumors that include medulloblastomas. Although genetic models of a subset of medulloblastomas are documented over the past decade, the...
- 8From: Oncogene. (Vol. 27, Issue 32) Peer-ReviewedId-1 (Inhibitor of DNA binding/differential-1) plays a positive role in tumorigenesis through regulation of multiple signaling pathways. Recently, it is suggested that upregulation of Id-1 in cancer cells promotes...
- 9From: Oncogene. (Vol. 27, Issue 32) Peer-ReviewedThe homeobox gene Cdx1 is involved in anteroposterior patterning in embryos and its expression selectively persists in the intestinal epithelium throughout life. In human colon cancers, Cdx1 is overexpressed in few cases...
- 10From: Oncogene. (Vol. 27, Issue 32) Peer-ReviewedHyperactivation of ErbB signaling is implicated in metastatic breast cancer. However, the mechanisms that cause dysregulated ErbB signaling and promote breast carcinoma cell invasion remain poorly understood. One pathway...
- 11From: Oncogene. (Vol. 27, Issue 32) Peer-ReviewedMutant forms of the c-ABL gene are well known to be involved in hematopoietic malignancies such as chronic myeloid leukemia (CML). CML patients possess a fused BCR-ABL gene that activates the Abl tyrosine kinase domain...
- 12From: Oncogene. (Vol. 27, Issue 32) Peer-ReviewedPaclitaxel (PTX) and other microtubule inhibitors cause mitotic arrest. However, low concentrations of PTX (low PTX) paradoxically cause G1 arrest (without mitotic arrest). Here, we demonstrated that unexpectedly, low...
- 13From: Oncogene. (Vol. 27, Issue 32) Peer-ReviewedGlycogen synthase kinase-3 (GSK-3β) regulates microtubule dynamics and cellular polarity through phosphorylating various microtubule associating proteins and plus-end tracking proteins. Although it was also reported that...