Showing Results for
- Academic Journals (15)
Search Results
- 15
Academic Journals
- 15
- Search Terms:
- 1From: Oncogene. (Vol. 27, Issue 14) Peer-ReviewedAn ERG gene 'break-apart' fluorescence in situ hybridization (FISH) assay has been used to screen whole-mount prostatectomy specimens for rearrangements at the ERG locus. In cancers containing ERG alterations the...
- 2From: Oncogene. (Vol. 27, Issue 14) Peer-ReviewedAlveolar rhabdomyosarcomas (ARMS) escape terminal differentiation despite exhibiting a skeletal muscle phenotype. To understand the role of the ARMS-specific PAX-FKHR proteins in myogenesis, we characterized their...
- 3From: Oncogene. (Vol. 27, Issue 14) Peer-ReviewedTumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL/Apo2L) is a promising candidate for cancer therapy, however, emergence of drug resistance limits its potential use. Here, we report for the first time...
- 4From: Oncogene. (Vol. 27, Issue 14) Peer-ReviewedAstrocytic, oligodendroglial and mixed gliomas are the commonest gliomas in adults. They have distinct phenotypes and clinical courses, but as they exist as a continuous histological spectrum, differentiating them can be...
- 5From: Oncogene. (Vol. 27, Issue 14) Peer-ReviewedN-methyl-D-aspartate receptors (NMDARs) are the predominant excitatory neurotransmitter receptors in the mammalian brain. We found that among the three NMDARs examined (NMDAR1, NMDAR2A, NMDAR2B), only NMDAR2A was...
- 6From: Oncogene. (Vol. 27, Issue 14) Peer-ReviewedEwing's sarcoma (ES) is characterized by specific chromosome translocations, the most common being t(11;22)(q24,q12). Additionally, other type of genetic abnormalities may occur and be relevant for explaining the...
- 7From: Oncogene. (Vol. 27, Issue 14) Peer-ReviewedNon-small cell lung carcinomas (NSCLCs) are typically resistant against apoptosis induced bystand ard chemotherapy. We evaluated the effects of the two potential antitumor agents of the lamellarin class on a highly...
- 8From: Oncogene. (Vol. 27, Issue 14) Peer-ReviewedMicroRNAs (miRNAs) are ~22 nucleotide-long noncoding RNAs involved in several biological processes including development, differentiation and proliferation. Recent studies suggest that knowledge of miRNA expression...
- 9From: Oncogene. (Vol. 27, Issue 14) Peer-ReviewedATP-dependent SWI/SNF chromatin remodeling complexes regulate cell-cycle and play critical roles in a variety of differentiation pathways. The core subunit SNF5/INI1 is a tumor suppressor that is inactivated in a highly...
- 10From: Oncogene. (Vol. 27, Issue 14) Peer-ReviewedMetastasis-associated tumor antigen 1 (MTA1), a component of the nucleosome remodeling and deacetylating (NuRD) complex is routinely upregulated in several cancers. In the present study, we investigated the potential...
- 11From: Oncogene. (Vol. 27, Issue 14) Peer-ReviewedSrc activation has been associated with colon cancers but the mechanism underlying Src activation is largely unknown. Csk-homologous kinase (CHK) can inhibit the kinase activity of certain Src kinase family members in...
- 12From: Oncogene. (Vol. 27, Issue 14) Peer-ReviewedSenescence is a mechanism that limits cellular lifespan and constitutes a barrier against cellular immortalization. To identify new senescence regulatory genes that might play a role in tumorigenesis, we have designed...
- 13From: Oncogene. (Vol. 27, Issue 14) Peer-ReviewedMutational activation of Ras promotes oncogenesis by controlling cell cycle regulation and cell survival. Ras-mediated activation of both, the PI3K/AKT pathway and the MEK/ERK pathway, can trigger downregulation of the...
- 14From: Oncogene. (Vol. 27, Issue 14) Peer-ReviewedThe BCR-ABL oncogene encodes an in-frame fusion protein containing N-terminal sequences derived from Bcr and C-terminal sequences derived from Abl. Bcr contains a centrally located Rho-specific guanine nucleotide...
- 15From: Oncogene. (Vol. 27, Issue 14) Peer-ReviewedScreening of therapeutics relies on representative cancer models. The representation of human glioblastoma by in vitro cell culture models is questionable. We obtained genomic profiles by array comparative genomic...