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- 1From: Oncogene. (Vol. 26, Issue 57) Peer-ReviewedA key step in activation of the p53 tumor suppressor is its transport into the nucleus; however, despite intensive study of p53, the regulation of its subcellular localization is still poorly understood. Here we examined...
- 2From: Oncogene. (Vol. 26, Issue 57) Peer-ReviewedArray-based comparative genomic hybridization (array-CGH) has good potential for the high-throughput identification of genetic aberrations in cell genomes. In the course of a program to screen a panel of oral...
- 3From: Oncogene. (Vol. 26, Issue 57) Peer-ReviewedMetaplastic carcinoma of the breast (MCB) is a poorly understood subtype of breast cancer. It is generally characterized by the coexistence of ductal carcinomatous and transdifferentiated sarcomatous components, but the...
- 4From: Oncogene. (Vol. 26, Issue 57) Peer-ReviewedCDC25 phosphatases control cell-cycle progression by dephosphorylating and activating cyclin-dependent kinases. CDC25B, one of the three members of this family in human cells, is thought to regulate initial mitotic...
- 5From: Oncogene. (Vol. 26, Issue 57) Peer-ReviewedThe purpose of this paper is to correlate the molecular phenotype of papillary thyroid carcinoma (PTC) to their biological pathology. We hybridized 26 PTC on microarrays and showed that nearly 44% of the transcriptome...
- 6From: Oncogene. (Vol. 26, Issue 57) Peer-ReviewedPhysiological signalling by the epidermal growth factor receptor (EGFRo) controls developmental processes and tissue homeostasis, whereas aberrant EGFR activity drives oncogenic cell transformation. Under normal...
- 7From: Oncogene. (Vol. 26, Issue 57) Peer-ReviewedEstradiol ([E.sub.2]) acts through the estrogen receptor (ER) to downregulate many genes, and tamoxifen (Tam) largely reverses this repression but the underlying mechanisms are unclear. Repression of the folate receptor...
- 8From: Oncogene. (Vol. 26, Issue 57) Peer-ReviewedCircadian rhythms regulate diverse physiological processes including homeostatic functions of steroid hormones and their receptors. Estrogen receptor-α (ERα) is essential for normal mammary gland physiology and is a...
- 9From: Oncogene. (Vol. 26, Issue 57) Peer-ReviewedMEN 2B (multiple endocrine neoplasia type 2B) is an autosomal dominant cancer syndrome caused by an oncogenic form of the receptor tyrosine kinase REarranged during transfection (RET). The MEN 2B syndrome is associated...
- 10From: Oncogene. (Vol. 26, Issue 57) Peer-ReviewedThe signaling mechanisms responsible for BCR/ABL-induced regulation of Mcl-1 expression in chronic myelogenous leukemia (CML) cells remain unclear. In this study, we show that BCR/ABL could upregulate sphingosine...
- 11From: Oncogene. (Vol. 26, Issue 57) Peer-ReviewedGermline LKB1 mutations are responsible for Peutz-Jeghers syndrome (PJS). Tumors at several locations frequently arise in these patients, confirming that LKB1 is linked to cancer predisposition and is therefore a bona...