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- 1From: Leukemia. (Vol. 26, Issue 3) Peer-ReviewedCutaneous T-cell lymphoma (CTCL) is the term for diseases characterized by primary accumulation of malignant T cells in the skin. Patients with the two predominant clinical forms of CTCL called mycosis fungoides (MF) and...
- 2From: Leukemia. (Vol. 26, Issue 3) Peer-ReviewedRescue chemotherapy or autologous stem cell transplantation (autoSCT) gives disappointing results in relapsed peripheral T-cell lymphomas (PTCLs). We have retrospectively evaluated the long-term outcome of 52 patients...
- 3From: Leukemia. (Vol. 26, Issue 3) Peer-ReviewedFollicular lymphoma (FL) is characterized by the balanced chromosomal translocation t(14;18)(q32;q21) in about 80-90% of the cases. This primary event is not sufficient for emergence of FL, and acquisition of secondary...
- 4From: Leukemia. (Vol. 26, Issue 3) Peer-ReviewedChronic lymphocytic leukemia (CLL) represents the most prevalent adult leukemia and is characterized by the accumulation of long-lived B lymphocytes. Despite significant advances in its therapy especially during the...
- 5From: Leukemia. (Vol. 26, Issue 3) Peer-ReviewedOne of the obstacles for the design of clinical trials in acute and chronic graft-versus-host disease (aGVHD, cGVHD) has been that the available classification criteria were imperfect. The historic definition of aGVHD...
- 6From: Leukemia. (Vol. 26, Issue 3) Peer-ReviewedTriptolide, isolated from the herb Tripterygium wilfordii, has been shown to potently induce apoptosis in various malignant cells by inhibiting RNA synthesis and nuclear factor-[kappa]B activity. Previously, we showed...
- 7From: Leukemia. (Vol. 26, Issue 3) Peer-ReviewedMicroRNAs (miRNAs) are important regulators of gene expression in the immune system. In a few short years, their mechanism of action has been described in various cell lineages within the immune system, targets have...
- 8From: Leukemia. (Vol. 26, Issue 3) Peer-ReviewedAcute myeloid leukemia (AML) represents a heterogeneous group of hematological neoplasms associated with the accumulation of acquired genetic and epigenetic aberrations in hematopoietic progenitor cells. Myeloid...
- 9From: Leukemia. (Vol. 26, Issue 3) Peer-ReviewedIsocitrate dehydrogenase (IDH1 and IDH2) mutations can be detected in brain tumors (1-3) and acute myeloid leukemia (AML) (4-7) and are associated with distinct clinical and biological features. The mutations in these...
- 10From: Leukemia. (Vol. 26, Issue 3) Peer-ReviewedIsocitrate dehydrogenase (IDH) mutations are frequent in blast-phase myeloproliferative neoplasms and might therefore contribute to leukemic transformation. We examined this possibility in 301 consecutive patients with...
- 11From: Leukemia. (Vol. 26, Issue 3) Peer-ReviewedFoci of iron deposition in the perinuclear mitochondria of erythroid precursors, called ring sideroblasts (RS), can be seen in acquired and congenital cases of anemia. In many patients with...
- 12From: Leukemia. (Vol. 26, Issue 3) Peer-ReviewedWilms tumor gene, WT1, is highly expressed in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL), and has an essential role in leukemogenesis. (1) The gene product (WT1 protein) could be a good target...
- 13From: Leukemia. (Vol. 26, Issue 3) Peer-ReviewedEven though human acute myeloid leukemia (AML) is characterized by an expansion of malignant myeloblasts, these immature leukemic cells can show signs of differentiation both by morphological examination and by...
- 14From: Leukemia. (Vol. 26, Issue 3) Peer-ReviewedRisk of developing some cancers is markedly increased in settings of immune suppression including after solid organ transplants and in persons with inherited immune-deficiency disorders and those with HIV-1 infection....
- 15From: Leukemia. (Vol. 26, Issue 3) Peer-ReviewedAlthough BCR-ABL+ stem cells in chronic myeloid leukemia (CML) resist elimination by targeted pharmacotherapy in most patients, immunological graft-versus-leukemia effects can cure the disease. Besides cytotoxic T...
- 16From: Leukemia. (Vol. 26, Issue 3) Peer-ReviewedArsenic trioxide (ATO) is presently the most active single agent in the treatment of acute promyelocytic leukemia (APL). This review provides insights into the mode of action and the pharmacological properties of ATO,...
- 17From: Leukemia. (Vol. 26, Issue 3) Peer-ReviewedA strict balance between self-renewal and differentiation of hematopoietic stem cells (HSCs) is required in order to maintain homeostasis, as well as to efficiently respond to injury and infections. Numbers and fate...
- 18From: Leukemia. (Vol. 26, Issue 3) Peer-ReviewedThe vitamin E derivative (+)[alpha]-tocopheryl succinate ([alpha]-TOS) exerts pro-apoptotic effects in a wide range of tumors and is well tolerated by normal tissues. Previous studies point to a mitochondrial...
- 19From: Leukemia. (Vol. 26, Issue 3) Peer-ReviewedTimely diagnosis of impending graft rejection is crucial for effective therapeutic intervention after allogeneic hematopoietic stem cell transplantation (SCT). We have investigated the predictive potential of early...
- 20From: Leukemia. (Vol. 26, Issue 3) Peer-ReviewedMicroRNAs (miRNAs) are small non-coding RNA molecules that can negatively regulate gene expression at the post-transcriptional level. miRNA expression patterns are regulated during development and differentiation of the...