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- Search Terms:ISSN: 10870156AndISSN: 15461696AndVolume Number: 25AndIssue Number: 7AndStart Page: 786AndDate: 2007 Revise Search
- 1From: Nature Biotechnology. (Vol. 25, Issue 7) Peer-Reviewed
Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases
Artificial endonucleases consisting of a FokI cleavage domain tethered to engineered zinc-finger DNA-binding proteins have proven useful for stimulating homologous recombination in a variety of cell types. Because the...