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- 1From: Pediatric Nephrology. (Vol. 25, Issue 4) Peer-ReviewedSirs, In developed countries, the field of pediatric nephrology is progressing continuously, primarily due to the many recent advances in the areas of physiology, genetics, imaging, and therapeutics. Consequently, a...
- 2From: Pediatric Nephrology. (Vol. 25, Issue 4) Peer-ReviewedIn mammals, the somatic growth rate is rapid during fetal and early postnatal life and then gradually declines and eventually stops. In search of the fundamental biological mechanism causing coordinated growth...
- 3From: Pediatric Nephrology. (Vol. 25, Issue 4) Peer-ReviewedThere are a number of hypophosphatemic disorders due to renal phosphate wasting that cannot be explained by elevated levels of parathyroid hormone. The circulating factors responsible for the phosphaturia have been...
- 4From: Pediatric Nephrology. (Vol. 25, Issue 4) Peer-ReviewedRecent advances in our understanding of the excess mortality of chronic kidney disease (CKD) due to cardiovascular complications, obtained through observational studies, demonstrate that vascular calcification and...
- 5From: Pediatric Nephrology. (Vol. 25, Issue 4) Peer-ReviewedThe goal of the study is to examine the relationship between the sensor molecules, Hypoxia Inducible Factor-1 (HIF-1), AMP activated Protein Kinase (AMPK) and mammalian Target of Rapamycin (mTOR) in chondrocyte...
- 6From: Pediatric Nephrology. (Vol. 25, Issue 4) Peer-ReviewedSkeletal muscle is the major constituent of lean body mass and a major determinant of energy expenditure both at rest and during physical activity. Growth hormone, in turn, influences muscle mass as well as energy...
- 7From: Pediatric Nephrology. (Vol. 25, Issue 4) Peer-ReviewedAt present, new compounds are available to treat secondary hyperparathyroidism, namely calcimimetics, novel phosphorus binders and also novel vitamin D receptor activators. Calcimimetics increase the sensitivity of the...
- 8From: Pediatric Nephrology. (Vol. 25, Issue 4) Peer-ReviewedSirs, Proximal tubular dysfunction is, in general, more common when the nephrotic syndrome is associated with focal segmental glomerulosclerosis (FSGS) than with minimal-change nephrotic syndrome. Although it has...
- 9From: Pediatric Nephrology. (Vol. 25, Issue 4) Peer-ReviewedThe post-transplant bone disease of the peripheral skeleton in pediatric renal transplant recipients is characterized by an inadequately thin bone cortex in relation to muscular force. A major hormonal modulator of...
- 10From: Pediatric Nephrology. (Vol. 25, Issue 4) Peer-ReviewedGrowth retardation remains a major complication in children with primary tubular disorders, despite adequate supplemental treatment with electrolytes, water and bicarbonate. Chronic hypokalemia, characteristic of some...
- 11From: Pediatric Nephrology. (Vol. 25, Issue 4) Peer-ReviewedInfants with a very low birth weight are at risk of a reduced number of nephrons predisposing to kidney disorder, hypertension, and metabolic syndrome. Approximately 3% of infants are born small for gestational age...
- 12From: Pediatric Nephrology. (Vol. 25, Issue 4) Peer-ReviewedThe vast majority of kidney transplant recipients undergo triple maintenance immunosuppression that includes the use of steroids. Irrespective of their long history in organ transplantation and proven efficacy in...
- 13From: Pediatric Nephrology. (Vol. 25, Issue 4) Peer-ReviewedRecent studies have demonstrated that levels of fibroblast growth factor 23 (FGF-23), a key regulator of phosphorus and vitamin D metabolism, rise dramatically as renal function declines and may play a key initiating...
- 14From: Pediatric Nephrology. (Vol. 25, Issue 4) Peer-ReviewedChronic inflammation is associated with cachexia and increased mortality risk in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD). Inflammation suppresses appetite and causes the loss of...
- 15From: Pediatric Nephrology. (Vol. 25, Issue 4) Peer-ReviewedBone growth occurs in the growth-plate cartilage located at the ends of long bones. Changes in the architecture, abnormalities in matrix organization, reduction in protein staining and RNA expression of factors involved...
- 16From: Pediatric Nephrology. (Vol. 25, Issue 4) Peer-ReviewedTherapeutic recreation camps benefit children and young people with chronic illness [1]. The outdoor and group activities enhance self esteem and peer support as well as provide carers with a 'break' from the burden of...
- 17From: Pediatric Nephrology. (Vol. 25, Issue 4) Peer-ReviewedThis review discusses the indications for enteral feeding in children with chronic kidney disease, the types of feeding tubes that can be used, methods of insertion and their benefits and complications. Keywords...
- 18From: Pediatric Nephrology. (Vol. 25, Issue 4) Peer-ReviewedDuring endochondral ossification bones are formed as cartilage templates in which chondrocytes proliferate, differentiate into hypertrophic chondrocytes and are gradually replaced by bone. Postnatally, remnants of...
- 19From: Pediatric Nephrology. (Vol. 25, Issue 4) Peer-ReviewedCardiovascular complications occurring in adults find their roots in risk factors operating early in life. Among the factors influencing cardiovascular risk, blood pressure values in children represent an important...
- 20From: Pediatric Nephrology. (Vol. 25, Issue 4) Peer-ReviewedRecent studies have identified a novel bone--kidney endocrine axis that maintains phosphate homeostasis. When phosphate is in excess, fibroblast growth factor-23 (FGF23) is secreted from bone and acts on the kidney to...