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- 1From: Leukemia. (Vol. 25, Issue 2) Peer-ReviewedNatural killer (NK) cell lymphomas/leukemias are rare neoplasms with an aggressive clinical behavior. The majority of the cases belong to extranodal NK/T-cell lymphoma, nasal type (ENKTL) in the current WHO...
- 2From: Leukemia. (Vol. 25, Issue 2) Peer-ReviewedThe phosphatidylinositol 3-kinase signal transduction pathway members are often activated in tumor samples from patients with non-Hodgkin's lymphoma (NHL). Everolimus is an oral agent that targets the raptor mammalian...
- 3From: Leukemia. (Vol. 25, Issue 2) Peer-ReviewedPrevious experience in the treatment of chronic myeloid leukaemia (CML) has shown that the achievement of clinical, morphological and cytogenetic remission does not indicate eradication of the disease. A complete...
- 4From: Leukemia. (Vol. 25, Issue 2) Peer-ReviewedClinical studies using genetic randomization cannot accurately answer whether adult patients with Philadelphia chromosome-negative acute lymphoblastic leukemia (ALL) who have a human leukocyte antigen (HLA)-matched...
- 5From: Leukemia. (Vol. 25, Issue 2) Peer-ReviewedTransformation by tyrosine kinase oncogenes (TKOs) in myeloid malignancies, including BCR-ABL in chronic myeloid leukemia, FLT3ITD in acute myeloid leukemia or JAK2V617F in myeloproliferative neoplasms, is associated...
- 6From: Leukemia. (Vol. 25, Issue 2) Peer-ReviewedTranslocation (12;21), the most frequent chromosomal aberration in childhood acute lymphoblastic leukemia, creates TEL/AML1 fusion gene. Resulting hybrid protein was shown to have a role in pre-leukemia establishment....
- 7From: Leukemia. (Vol. 25, Issue 2) Peer-ReviewedThe transforming growth factor (TGF)-[beta] superfamily has been implicated into different physiological and pathological processes in a broad range of cell systems, including fibroblasts, immune, stem, endothelial,...
- 8From: Leukemia. (Vol. 25, Issue 2) Peer-ReviewedUnder normal conditions, the great majority of hematopoietic stem/progenitors cells (HSPCs) reside in the bone marrow. The number of HSPCs in the circulation can be markedly increased in response to a number of stimuli,...
- 9From: Leukemia. (Vol. 25, Issue 2) Peer-ReviewedBCR--ABL-targeting tyrosine kinase inhibitors (TKIs) constitute the cornerstone of treatment for chronic myeloid leukemia. Although these agents are normally safe and effective, they can cause side effects that lead to...
- 10From: Leukemia. (Vol. 25, Issue 2) Peer-ReviewedIncreased expression of BAFF (B cell-activating factor belonging to the TNF family) and its receptors has been identified in numerous B-cell malignancies. A soluble human BAFF mutant (mBAFF), binding to BAFF receptors...
- 11From: Leukemia. (Vol. 25, Issue 2) Peer-ReviewedMonosomal karyotype (MK) refers to the presence of two or more distinct autosomal monosomies or a single monosomy associated with a structural abnormality. In acute myeloid leukemia, MK has been shown to be...
- 12From: Leukemia. (Vol. 25, Issue 2) Peer-ReviewedThe recent World Health Organization (WHO) classification clearly defined a new entity, named 'myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB and FGFR1', as a category of three rare...
- 13From: Leukemia. (Vol. 25, Issue 2) Peer-ReviewedCorrection to: Leukemia (2010) 11, 1927-1933; doi:10.1038/ leu.2010.160 Since the publication of the above paper, the authors have noticed an error in Supplementary Tables 1 and 3. The authors would like to...
- 14From: Leukemia. (Vol. 25, Issue 2) Peer-ReviewedThe association between azacitidine (AZA) and valproic acid (VPA) has shown high response rates in high-risk myelodysplastic syndromes (MDS) cases with unfavorable prognosis. However, little is known about the molecular...
- 15From: Leukemia. (Vol. 25, Issue 2) Peer-ReviewedIn a previous study, we reported on the safety and efficacy of low-dose (0.5 mg) pomalidomide and prednisone and pomalidomide alone (2 mg/day), for the treatment of anemia associated with myelofibrosis (MF). The current...
- 16From: Leukemia. (Vol. 25, Issue 2) Peer-ReviewedABL gene translocations create constitutively active tyrosine kinases that are causative in chronic myeloid leukemia, acute lymphocytic leukemia and other hematopoietic malignancies. Consistent retention of ABL SH3/SH2...
- 17From: Leukemia. (Vol. 25, Issue 2) Peer-ReviewedCorrection to: Leukemia advance online publication, 16 September 2010; doi:10.1038/leukemia.2010.197 Since the publication of this article, the authors have noticed several errors that appeared in the online version...
- 18From: Leukemia. (Vol. 25, Issue 2) Peer-ReviewedParoxysmal nocturnal hemoglobinuria (PNH) is an acquired hematopoietic stem cell disorder characterized by a global deficiency of glycosylphospatidyl inositol-anchored proteins (GPI-APs) on the membrane of all cell...
- 19From: Leukemia. (Vol. 25, Issue 2) Peer-ReviewedEpigenetic changes have been identified in recent years as important factors in the pathogenesis of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Histone deacetylase inhibitors (HDACIs) regulate the...
- 20From: Leukemia. (Vol. 25, Issue 2) Peer-ReviewedThrombocytopenia is a common side-effect of cytotoxic chemotherapy and novel targeted agents that can often necessitate the use of platelet transfusions, or result in dose modifications or discontinuation of therapy....