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- 1From: Leukemia. (Vol. 23, Issue 8) Peer-ReviewedUbiquitination plays a major role in many aspects of hematopoiesis. Alterations in ubiquitination have been implicated in hematological cancer. The ubiquitin ligase Triad1 controls the proliferation of myeloid cells....
- 2From: Leukemia. (Vol. 23, Issue 8) Peer-ReviewedInteractions between inhibitors of the proteasome and histone deacetylases have been examined in human T-leukemia/ lymphoma cells both in vitro and in vivo. Co-exposure of cells to bortezomib and suberoylanilide...
- 3From: Leukemia. (Vol. 23, Issue 8) Peer-ReviewedDasatinib, a broad-spectrum tyrosine kinase inhibitor (TKI), predominantly targets BCR-ABL and SRC oncoproteins and also inhibits off-target kinases, which may result in unexpected drug responses. We identified 22...
- 4From: Leukemia. (Vol. 23, Issue 8) Peer-ReviewedBcr-Abl causes chronic myelogenous leukemia, a myeloproliferative disorder characterized by clonal expansion of hematopoietic progenitor cells. In this study, inducible expression of Bcr-Abl in TonB.210 cells is...
- 5From: Leukemia. (Vol. 23, Issue 8) Peer-ReviewedA standardized, sensitive and universal method for minimal residual disease (MRD) detection in acute myeloid leukemia (AML) is still pending. Although hyperexpression of Wilms' tumor (WT1) gene transcript has been...
- 6From: Leukemia. (Vol. 23, Issue 8) Peer-ReviewedIt is an open question whether in multiple myeloma (MM) bone marrow stromal cells contain genomic alterations, which may contribute to the pathogenesis of the disease. We conducted an array-based comparative genomic...
- 7From: Leukemia. (Vol. 23, Issue 8) Peer-ReviewedOnce cleaved by caspases, the Lyn tyrosine kinase (LynΔN) is relocalized from the plasma membrane to the cytoplasm of apoptotic cells, but the function of such a cleavage is incompletely understood. We evaluated the...
- 8From: Leukemia. (Vol. 23, Issue 8) Peer-ReviewedChromosomal rearrangements of the human MLL gene are associated with high-risk pediatric, adult and therapy-associated acute leukemias. These patients need to be identified, treated appropriately and minimal residual...
- 9From: Leukemia. (Vol. 23, Issue 8) Peer-ReviewedOne of the earlier names used to describe myelodysplastic syndromes (MDS) was 'refractory anemia' because of their resistance to the therapy known at the time. (1) It is ironic that 'refractory anemia' of yesteryear...
- 10From: Leukemia. (Vol. 23, Issue 8) Peer-ReviewedGemtuzumab ozogamicin (GO, Mylotarg) is a targeted therapeutic agent in which an anti-CD33 antibody is chemically coupled to a highly cytotoxic calicheamicin derivative through a hydrolysable linker. GO has improved the...
- 11From: Leukemia. (Vol. 23, Issue 8) Peer-ReviewedCytopenia represents a significant complication after chemotherapy, irradiation before bone marrow (BM) transplantation or as a therapy for cancer. The mechanisms that determine the pace of BM recovery are not fully...
- 12From: Leukemia. (Vol. 23, Issue 8) Peer-ReviewedOmacetaxine mepesuccinate (formerly homoharringtonine) is a molecule with a mechanism of action that is different from tyrosine kinase inhibitors, and its activity in chronic myeloid leukemia (CML) seems to be...
- 13From: Leukemia. (Vol. 23, Issue 8) Peer-ReviewedRunt-related transcription factor 1 (RUNX1) is essential for normal hematopoiesis. RUNX1 mutations have rarely been reported in chronic myelomonocytic leukemia (CMML). We examined RUNX1 mutations in 81 patients with CMML...
- 14From: Leukemia. (Vol. 23, Issue 8) Peer-ReviewedTo evaluate the impact of contemporary therapy on the clinical outcome of children with pre-B acute lymphoblastic leukemia (ALL) and the t(1;19)/TCF3/PBX1, we analyzed 735 patients with B-cell precursor ALL treated in...
- 15From: Leukemia. (Vol. 23, Issue 8) Peer-ReviewedBecause cladribine can increase cytarabine triphosphate levels, we tested a cladribine-cytarabine combination in the St Jude AML97, trial in which this combination was administered before standard chemotherapy to 96...
- 16From: Leukemia. (Vol. 23, Issue 8) Peer-ReviewedAcute promyelocytic leukemia (APL) is characterized by hyperproliferation of promyelocytes, progenitors that are committed to terminal differentiation into granulocytes, making it an ideal disease in which to study the...
- 17From: Leukemia. (Vol. 23, Issue 8) Peer-ReviewedThe international staging system (ISS) for multiple myeloma (MM) is a validated alternative to the Durie-Salmon staging system (DSS) for predicting survival at diagnosis. We compared these staging systems for predicting...
- 18From: Leukemia. (Vol. 23, Issue 8) Peer-ReviewedInhibition of NOTCHi signaling with y-secretase inhibitors (GSIs) has been proposed as a molecularly targeted therapy in T-cell acute lymphoblastic leukemia (T-ALL). However, GSIs seem to have limited antileukemic...
- 19From: Leukemia. (Vol. 23, Issue 8) Peer-ReviewedWe reported that complement (C) becomes activated and cleaved in bone marrow during preconditioning for hematopoietic transplantation and the third C component (C3) cleavage fragments, C3a and [sup.desArg]C3a, increase...
- 20From: Leukemia. (Vol. 23, Issue 8) Peer-ReviewedSomatic mutations in Janus kinase 2 (JAK2), including JAK2V617F, result in dysregulated JAK-signal transducer and activator transcription (STAT) signaling, which is implicated in myeloproliferative neoplasm (MPN)...