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- 1From: Oncogene. (Vol. 23, Issue 56) Peer-ReviewedAuthor(s): Noriyoshi Fukushima [1]; Norihiro Sato [1]; Nijaguna Prasad [2]; Steven D Leach [2]; Ralph H Hruban [1, 3]; Michael Goggins [1, 3, 4] Mucinous cystic neoplasms (MCNs) of the pancreas are relatively rare...
- 2From: Oncogene. (Vol. 23, Issue 56) Peer-ReviewedAuthor(s): Lin Wei [1, 2]; Yu Yang [1, 2]; Xin Zhang [1, 2]; Qiang Yu [1, 2, 3] Src was initially discovered as the oncogenic protein (v-Src) of the retrovirus Rous sarcoma virus. Later, the cellular counterpart of...
- 3From: Oncogene. (Vol. 23, Issue 56) Peer-ReviewedAuthor(s): Yoshihiro Kameoka [1]; Hiroyuki Tagawa [1]; Shinobu Tsuzuki [1]; Sivasundaram Karnan [1]; Akinobu Ota [1]; Miyuki Suguro [1]; Ritsuro Suzuki [1]; Motoko Yamaguchi [2]; Yasuo Morishima [3]; Shigeo Nakamura [4];...
- 4From: Oncogene. (Vol. 23, Issue 56) Peer-ReviewedAuthor(s): Wen Deng [1]; Sai Wah Tsao [1]; Xin-Yuan Guan [2]; Joe N Lucas [3]; Hua Xin Si [1]; Chi Shing Leung [4]; Priscilla Mak [4]; Li Dong Wang [5]; Annie L M Cheung [1] Telomeres are specialized DNA-protein...
- 5From: Oncogene. (Vol. 23, Issue 56) Peer-ReviewedAuthor(s): Sergey A Sinenko [1]; Bernard Mathey-Prevot [1] Tetraspanins are abundantly expressed proteins characterized by four transmembrane domains delimiting two extracytoplasmic loops of unique sizes that define a...
- 6From: Oncogene. (Vol. 23, Issue 56) Peer-ReviewedAuthor(s): Yonghe Li [1]; Wenyan Lu [1]; Xi He [2]; Alan L Schwartz [1, 3]; Guojun Bu [1, 4] The Wnt canonical signaling pathway is involved in various differentiation events during embryonic development and can lead...
- 7From: Oncogene. (Vol. 23, Issue 56) Peer-ReviewedAuthor(s): Dimitri Lodygin [1]; Joachim Diebold [2]; Heiko Hermeking [1] Prostate cancer (PCa) is the most commonly diagnosed malignancy in the male population of the Western world. For the year 2004, it is estimated...
- 8From: Oncogene. (Vol. 23, Issue 56) Peer-ReviewedAuthor(s): Manfred Fliegauf [1, 2]; Michael Stock [1, 3]; Tobias Berg [1]; Michael Lübbert [1] The translocation (8;21) is the most frequent chromosomal abnormality found in human acute myeloid leukemia (AML) of the...
- 9From: Oncogene. (Vol. 23, Issue 56) Peer-ReviewedAuthor(s): Palma Rocchi [1, 3]; Xavier Muracciole [2]; Frederic Fina [1]; Dave J Mulholland [3]; Gilles Karsenty [4]; Jacqueline Palmari [1]; L'Haucine Ouafik [1]; Franck Bladou [4]; Pierre-Marie Martin [1] Prostate...
- 10From: Oncogene. (Vol. 23, Issue 56) Peer-ReviewedAuthor(s): Alan McIntyre [1]; Brenda Summersgill [1]; Osman Jafer [1]; Sandrine Rodriguez [1]; Gaetano Zafarana [2]; J Wolter Oosterhuis [2]; Ad JM Gillis [2]; Leendert Looijenga [2]; Colin Cooper [3]; Robert Huddart...
- 11From: Oncogene. (Vol. 23, Issue 56) Peer-ReviewedThe expression of the tumour suppressor protein fragile histidine triad (Fhit) is often impaired in many human cancers and its restoration in Fhit-negative cancer cell lines suppresses tumorigenicity and induces...
- 12From: Oncogene. (Vol. 23, Issue 56) Peer-ReviewedThe tumor suppressor protein p53 is emerging as a central regulator of homologous recombination (HR) processes and DNA replication. P53 may downregulate HR through multiple mechanisms including the reported associations...
- 13From: Oncogene. (Vol. 23, Issue 56) Peer-ReviewedThe BRCA2 tumour suppressor protein is involved in maintaining genetic stability through its role in homologous recombination (HR), where it mediates RAD51-dependent strand invasion. Here, we show that BRCA2-defective...
- 14From: Oncogene. (Vol. 23, Issue 56) Peer-ReviewedASPP1 and ASPP2 are both proteins that interact with p53 and enhance its ability to induce apoptosis by selectively elevating the expression of proapoptotic p53-responsive genes. iASPP(RAI) is a third member of the...
- 15From: Oncogene. (Vol. 23, Issue 56) Peer-ReviewedMitotic recombination (MR) between chromosome homologs in somatic cells is a major pathway to the loss of heterozygosity (LOH), which may cause cancer if tumor suppressor genes are involved. MR can be suppressed by DNA...
- 16From: Oncogene. (Vol. 23, Issue 56) Peer-ReviewedAn important role of the cell cycle regulatory protein cyclin A1 in the development of acute myeloid leukemia (AML) was previously demonstrated in a transgenic mouse model. We have now turned our attention to study...
- 17From: Oncogene. (Vol. 23, Issue 56) Peer-ReviewedWe previously demonstrated that protein kinase C-[eta]; (PKC-[eta];) mediates a phorbol 12-myristate-13-acetate (PMA)-induced proliferative response in human glioblastoma (GBM) cells. In this report, we show that...