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- 1From: Leukemia. (Vol. 23, Issue 2) Peer-ReviewedA few studies have reported that AML1-MTG8 expression levels in bone marrow (BM) are 1- to 3-log higher than those in peripheral blood (PB) when detected by quantitative PCR methods in acute myeloid leukemia (AML) with...
- 2From: Leukemia. (Vol. 23, Issue 2) Peer-ReviewedFludarabine exposure leads to impaired peripheral blood stem cell (PBSC) mobilization in indolent lymphoproliferative disorders (1-1313). We previously reported that only 34% of fludarabine-exposed patients mobilized...
- 3From: Leukemia. (Vol. 23, Issue 2) Peer-ReviewedHyperglycemia adversely affects outcome in adult patients with acute lymphoblastic leukemia (ALL), but its impact on children with this disease is unknown. We evaluated the relationship between hyperglycemia during...
- 4From: Leukemia. (Vol. 23, Issue 2) Peer-ReviewedClinical studies showed that advanced stage, high LDH, poor response to reduction therapy and combined bone marrow and central nervous system disease are significantly associated with a decreased event-free survival...
- 5From: Leukemia. (Vol. 23, Issue 2) Peer-ReviewedRetinoic acid receptors (RARs) are members of a much larger group of ligand-dependent transcription factors, the so-called nuclear receptors. In mammals, there are three distinct RAR subtypes: Ma, RARP and My. (1) RARs...
- 6From: Leukemia. (Vol. 23, Issue 2) Peer-ReviewedCCAAT/enhancer-binding protein α (C/EBPα) is mutated in 10% of acute myeloid leukemias, resulting in either a truncated protein or an altered leucine zipper (C/EBPαLZ) that prevents DNA binding. C/EBPα induces bcl-2 in...
- 7From: Leukemia. (Vol. 23, Issue 2) Peer-ReviewedMyeloproliferative neoplasms (MPNs) are clonal stem cell disorders characterized by chronic proliferation of hematopoietic progenitors. We studied the telomere length (TL) of 335 MPN patients and 93 gender- and...
- 8From: Leukemia. (Vol. 23, Issue 2) Peer-ReviewedAlterations in the expression and signalling pathways of vascular endothelial growth factor (VEGF) have been linked to the clinical features and pathogenesis of hematologic malignancies. In this study, we showed that...
- 9From: Leukemia. (Vol. 23, Issue 2) Peer-ReviewedWe have read with interest the editorial by Dr Bergsagel that accompanies the original article by Arzoumanian et al, which explores the complex relationship between cytogenetic abnormalities and clinical outcome in the...
- 10From: Leukemia. (Vol. 23, Issue 2) Peer-ReviewedHematopoietic stem cell fate has been largely associated with a regulatory environment commonly referred to as niche. (1) It remains unclear whether this microenvironment in the bone marrow is located in the endosteal...
- 11From: Leukemia. (Vol. 23, Issue 2) Peer-ReviewedIdentifying mechanisms responsible for the clinical heterogeneity of chronic lymphocytic leukemia (CLL) is important to develop better treatments for this disease. Variations in responsiveness to immunoreceptor signaling...
- 12From: Leukemia. (Vol. 23, Issue 2) Peer-ReviewedBurkitt lymphoma (BL) has a characteristic clinical presentation, morphology, immunophenotype and primary chromosomal aberration, that is, the translocation t(8;14)(g24;g32) or its variants. However, diagnostic dilemmas...
- 13From: Leukemia. (Vol. 23, Issue 2) Peer-ReviewedGemtuzumab ozogamicin (GO) consists of a humanized antiCD33 monoclonal antibody linked to calicheamicin, a potent anti-tumor antibiotic. Because approximately 90% of patients with acute myeloid leukemia (AML) have...
- 14From: Leukemia. (Vol. 23, Issue 2) Peer-ReviewedThe FIP1L1-PDGFRA fusion gene is a recurrent molecular abnormality in patients with eosinophilia-associated myeloproliferative neoplasms. We characterized FIP1L1-PDGFRA junction sequences from 113 patients at the mRNA...
- 15From: Leukemia. (Vol. 23, Issue 2) Peer-ReviewedAn early appreciation of treatment efficacy could be very useful in acute myeloblastic leukemia (AML), and a prognostic value has been suggested for the morphological assessment of decrease in blasts during induction...
- 16From: Leukemia. (Vol. 23, Issue 2) Peer-ReviewedPediatric acute lymphoblastic leukemia (ALL) is characterized by arrested differentiation of the malignant cell clone with retention of proliferative ability. Earlier we had demonstrated that the majority of leukemic...
- 17From: Leukemia. (Vol. 23, Issue 2) Peer-ReviewedEarlier reports have suggested that the BCR/ABL oncogene, associated with chronic myeloid leukemia, induces a mutator phenotype; however, it is unclear whether this leads to longterm changes in chromosomes and whether...
- 18From: Leukemia. (Vol. 23, Issue 2) Peer-ReviewedChronic myelomonocytic leukemia (CMML) and juvenile myelomonocytic leukemia are characterized by persistent monocytosis and combined dysplastic morphology with features of a myeloproliferative syndrome. (1) Together with...
- 19From: Leukemia. (Vol. 23, Issue 2) Peer-ReviewedB-cell chronic lymphocytic leukemia (CLL), the most common leukemia in older adults, remains largely incurable and novel treatments are urgently required. We previously reported powerful pro-apoptotic actions of...
- 20From: Leukemia. (Vol. 23, Issue 2) Peer-ReviewedABL is the main target of several tyrosine kinase inhibitors used in the treatment of chronic myeloid leukemia (CML) patients. ABL tyrosine kinase domain (TKD) point mutations are the main mechanism of acquired tyrosine...