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- 1From: Leukemia. (Vol. 23, Issue 10) Peer-ReviewedHuman umbilical cord blood (HUCB) provides a source of progenitors for cell therapy. We isolated and characterized an HUCB-derived population of progenitors (HUCBNP), differentiated toward neuronal phenotype by human...
- 2From: Leukemia. (Vol. 23, Issue 10) Peer-ReviewedInterleukin-21 (IL-21) has been recently shown to modulate the growth of specific types of B-cell neoplasm. Here, we studied the biological effects of IL-21 in mantle cell lymphoma (MCL). All MCL cell lines and tumors...
- 3From: Leukemia. (Vol. 23, Issue 10) Peer-ReviewedWe report the first documented case of an erythroid/B-cell biphenotypic acute leukemia. The most recent World Health Organization criteria for biphenotypic or mixed phenotype acute leukemia does not include an...
- 4From: Leukemia. (Vol. 23, Issue 10) Peer-ReviewedClinical and biological studies on nodal marginal zone lymphoma (NMZL) are hampered by the lack of specific diagnostic markers and the low reproducibility of this diagnosis. A comparative expression-profiling study has...
- 5From: Leukemia. (Vol. 23, Issue 10) Peer-ReviewedIn 2005, the first guidelines were published on the management of patients with multiple myeloma (MM). An expert panel reviewed the currently available literature as the basis for a set of revised and updated consensus...
- 6From: Leukemia. (Vol. 23, Issue 10) Peer-ReviewedPh-positive chronic myeloid leukemia (CML) and Ph-negative chronic myeloproliferative diseases (MPDs), characterized in many cases by the presence of the [JAK2.sup.V617F] mutation, have many features in common and yet...
- 7From: Leukemia. (Vol. 23, Issue 10) Peer-ReviewedThe prospect of applying differentiation therapies to the treatment of acute myeloid leukemias (AMLs) is highlighted by the use of all-trans retinoic acid (ATRA) in acute promyelocytic leukemia (APL). Treatment with...
- 8From: Leukemia. (Vol. 23, Issue 10) Peer-ReviewedThe aim of this prospective study was to investigate the feasibility of reduced-intensity conditioning (RIC) allogeneic stem cell transplantation (SCT) in 37 adults with high-risk acute lymphoblastic leukemia (ALL) in...
- 9From: Leukemia. (Vol. 23, Issue 10) Peer-ReviewedTyrosine kinase inhibitors have revolutionized the treatment of chronic myeloid leukemia (CML), offering patients several targeted therapeutic options that provide the possibility of sustained remissions and prolonged...
- 10From: Leukemia. (Vol. 23, Issue 10) Peer-ReviewedMultiple myeloma is the most common indication for high-dose chemotherapy with autologous stem cell support (ASCT) in North America today. Stem cell procurement for ASCT has most commonly been performed with stem cell...
- 11From: Leukemia. (Vol. 23, Issue 10) Peer-ReviewedCytarabine (Ara-C) is the most important element of standard acute myeloid leukemia (AML) treatment regimens since more than 40 years. However, response to Ara-C treatment is marked by significant inter-individual...
- 12From: Leukemia. (Vol. 23, Issue 10) Peer-ReviewedThe wingless-type (Wnt) signalling pathway is involved in leukemogenesis and the glycogen-synthase kinase 3[beta] has been reported to control both [beta]-catenin and nuclear factor (NF)-[kappa]B. (1) Thus, if...
- 13From: Leukemia. (Vol. 23, Issue 10) Peer-ReviewedWe observed that high-dose methylprednisolone (HDMP) and rituximab was well tolerated and had promising activity when used in combination to treat patients with fludarabine-refractory chronic lymphocytic leukemia (CLL)....
- 14From: Leukemia. (Vol. 23, Issue 10) Peer-ReviewedKinesin spindle protein (KSP), a microtubule-associated motor protein essential for cell cycle progression, is overexpressed in many cancers and is a potential anti-tumor target. We found that inhibition of KSP by a...
- 15From: Leukemia. (Vol. 23, Issue 10) Peer-ReviewedT-cell neoplasias are common in pediatric oncology, and include acute lymphoblastic leukemia (T-ALL) and lymphoblastic lymphoma (T-LBL). These cancers have worse prognoses than their B-cell counterparts, and their...
- 16From: Leukemia. (Vol. 23, Issue 10) Peer-ReviewedGeographic heterogeneity of cytogenetic patterns in hematological malignancies has been reported earlier, but few systematic studies of cytogenetic abnormalities in acute myeloid leukemia (AML) patients are available....
- 17From: Leukemia. (Vol. 23, Issue 10) Peer-ReviewedUsing dendritic cells (DCs) electroporated with whole RNA isolated from blasts of a patient with acute myeloid leukemia (AML), we were able to generate leukemia-specific cytotoxic T lymphocytes (CTLs) capable of...
- 18From: Leukemia. (Vol. 23, Issue 10) Peer-ReviewedMultiple myeloma (MM) is a B-cell malignancy, which often remains incurable because of the development of drug resistance governed by the bone marrow (BM) microenvironment. Novel treatment strategies are therefore...
- 19From: Leukemia. (Vol. 23, Issue 10) Peer-ReviewedTo determine the pattern of genetic alterations in primary central nervous system lymphomas (PCNSL), 19 PCNSL were studied by high-density single-nucleotide polymorphism arrays. Recurrent losses involved 6p21.32, 6q21,...
- 20From: Leukemia. (Vol. 23, Issue 10) Peer-ReviewedMonoclonal gammopathy of undetermined significance (MGUS) is one of the most common premalignant disorders in Western countries. Recent studies show that almost every multiple myeloma (MM) case is preceded by an MGUS...