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- 1From: Leukemia. (Vol. 22, Issue 9) Peer-ReviewedThe human MLL gene is frequently involved in genetic rearrangements, all of which associated with malignancies of the hematopoietic system. More than 50 rearrangements have so far been characterized at the molecular...
- 2From: Leukemia. (Vol. 22, Issue 9) Peer-ReviewedActivation of the phosphatidylinositol-3 kinase/Akt/mammalian target of the rapamycin (PI3K/Akt/mTOR) pathway and inactivation of wild-type p53 by murine double minute 2 homologue (Mdm2) overexpression are frequent...
- 3From: Leukemia. (Vol. 22, Issue 9) Peer-ReviewedThe phosphatidylinositol 3-kinase (PI3K)/Akt and mammalian target of rapamycin complex 1 (mTORC1) signaling pathways are frequently activated in acute myelogenous leukemia (AML). mTORC1 inhibition with RAD001 induces...
- 4From: Leukemia. (Vol. 22, Issue 9) Peer-ReviewedReduced-intensity conditioning (RIC) with conventional adult donor allogeneic graft sources is increasingly utilized for patients deemed unable to tolerate fully myeloablative conditioning due to advanced age and/or...
- 5From: Leukemia. (Vol. 22, Issue 9) Peer-ReviewedThe risk of secondary myelodysplastic syndromes/acute myeloid leukemia (tMDS/AML) after lymphoma treatment is still a matter of discussion, but a recent review concluded that it may reach 10% within 10 years of primary...
- 6From: Leukemia. (Vol. 22, Issue 9) Peer-ReviewedSeveral prognostic markers, including parameters of tumor burden and cytogenetics, were adopted to identify high-risk patients in multiple myeloma (MM). Recently, the International Staging System (ISS), including...
- 7From: Leukemia. (Vol. 22, Issue 9) Peer-ReviewedMyeloproliferative neoplasms (MPN; myeloproliferative disorders) are clonal stem cell diseases, defined by excessive production of cells in one or more hematopoietic lineages. Primary myelofibrosis (PMF), polycythemia...
- 8From: Leukemia. (Vol. 22, Issue 9) Peer-ReviewedRecent studies with very small numbers of patients showed that in some cases of childhood acute lymphoblastic leukemia (ALL), preleukemic cells are detectable on Guthrie cards that were used for newborn screening. We...
- 9From: Leukemia. (Vol. 22, Issue 9) Peer-ReviewedMicroRNAs are short single-stranded RNAs derived from precursors through processing by RNase III enzymes Drosha and Dicer. They function as gene regulators in a variety of physiological processes. Abnormal expression of...
- 10From: Leukemia. (Vol. 22, Issue 9) Peer-ReviewedAcute lymphoblastic leukemia (ALL) is the most common form of cancer in children. Survival rates for ALL have improved dramatically during the past 20 years. The goals of the current trials are to further improve...
- 11From: Leukemia. (Vol. 22, Issue 9) Peer-ReviewedAcute myeloid leukemia (AML) is intrinsically prone to resistance to conventional chemotherapeutic agents. Here, we explore the Rac family of small guanosine triphosphatases (GTPases) as novel biologic targets for AML...
- 12From: Leukemia. (Vol. 22, Issue 9) Peer-ReviewedL-asparaginase is an effective drug for treatment of children with acute lymphoblastic leukemia (ALL). The effectiveness is thought to result from depletion of asparagine in serum and cells. We investigated the clinical...
- 13From: Leukemia. (Vol. 22, Issue 9) Peer-ReviewedGlutathione S-transferases (GSTs) are phase II detoxification enzymes involved in the metabolism of carcinogens and anticancer drugs, known also to interact with kinase complexes during oxidative or chemical...
- 14From: Leukemia. (Vol. 22, Issue 9) Peer-ReviewedThe occurrence of graft-vs-host disease (GvHD) remains one of the major drawbacks limiting the wider application of allogeneic haematopoietic stem cell transplantation (HSCT) preceded by the use of a myeloablative...
- 15From: Leukemia. (Vol. 22, Issue 9) Peer-ReviewedChronic myeloid leukaemia (CML) is a clonal stem cell disorder, characterized at the cytogenetic level by the presence of a balanced chromosomal rearrangement, the t(9;22) or Philadelphia chromosome (Ph) translocation...
- 16From: Leukemia. (Vol. 22, Issue 9) Peer-ReviewedMyeloid leukemias, although a heterogeneous group of hematopoietic stem cell neoplasms, are arguably among the most suited for active specific immunotherapy. Nevertheless, clinical development of myeloid leukemia vaccine...
- 17From: Leukemia. (Vol. 22, Issue 9) Peer-ReviewedDeregulation of cell signaling pathways controlling cell growth and cell survival is a common feature of all cancers. Although a core repertoire of oncogenic mechanisms is widely conserved between various malignancies,...
- 18From: Leukemia. (Vol. 22, Issue 9) Peer-ReviewedAzacitidine is a pyrimidine nucleoside analog of cytidine with hypomethylatiog and antileukemia activity. Azacitidine has been shown to have survival benefits in patients with high-risk myelodysplastic syndrome (MDS),...
- 19From: Leukemia. (Vol. 22, Issue 9) Peer-ReviewedWe previously reported that TG101209, a JAK2-selective small molecule inhibitor, inhibits ex vivo hematopoietic colony growth in the context of myeloproliferative disorder (MPD)-relevant JAK2V617F and MPLW515L/K...
- 20From: Leukemia. (Vol. 22, Issue 9) Peer-ReviewedEarly death (ED) during the induction phase is a rare but dramatic event in children with acute myeloid leukemia (AML). (1) Recent reports emphasized that ED in patients with leukemia is related to the aggressive...