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- 1From: Oncogene. (Vol. 21, Issue 45) Peer-ReviewedAuthor(s): Binaifer R Balsara [1]; Joseph R Testa [1] Consistent chromosome changes are thought to be indicative of critical molecular events involved in tumorigenesis. Some of these chromosome alterations, primarily...
- 2From: Oncogene. (Vol. 21, Issue 45) Peer-ReviewedAuthor(s): Ana I Robles [1]; Steven P Linke [1]; Curtis C Harris [1] Since the discovery of the tumor suppressor p53 nearly two decades ago, an overwhelming volume of literature has accumulated supporting its role as a...
- 3From: Oncogene. (Vol. 21, Issue 45) Peer-ReviewedAuthor(s): Takashi Takahashi 1 Author Affiliations: (1) Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya, Japan There are over one million deaths a year worldwide due to lung cancer,...
- 4From: Oncogene. (Vol. 21, Issue 45) Peer-ReviewedAuthor(s): Akira Masuda [1]; Takashi Takahashi [1] High fidelity DNA replication and faithful chromosome segregation are fundamentally essential processes allowing cells to transmit their genetic information to the...
- 5From: Oncogene. (Vol. 21, Issue 45) Peer-ReviewedAuthor(s): Annette McWilliams [1, 5]; Calum MacAulay [2]; Adi F Gazdar [3]; Stephen Lam [4] Lung cancer is the most common cause of cancer death worldwide (Statistical Annex, 2000). Less than 15% of patients with lung...
- 6From: Oncogene. (Vol. 21, Issue 45) Peer-ReviewedAuthor(s): Yoshinori Murakami [1] Most of the tumor suppressor genes in human cancers are originally identified by positional cloning of a chromosomal region that is defined by linkage analysis of the pedigrees in...
- 7From: Oncogene. (Vol. 21, Issue 45) Peer-ReviewedAuthor Affiliations: Figure 1Dr Takashi Takahashi obtained his MD in 1979 from Nagoya University, Japan, and was initially trained in surgery, specializing in thoracic surgery. After completion of research work at the...
- 8From: Oncogene. (Vol. 21, Issue 45) Peer-ReviewedAuthor(s): Eugene R Zabarovsky [1]; Michael I Lerman [2]; John D Minna [3] Allele loss (deletion) mapping of human chromosome 3 Allele loss and deletion mapping using microsatellite markers and the detection of...
- 9From: Oncogene. (Vol. 21, Issue 45) Peer-ReviewedThe p53 tumor suppressor gene lies at the crossroads of multiple cellular response pathways that control a cell's fate in response to endogenous or exogenous stresses. Positive and negative regulatory loops both...
- 10From: Oncogene. (Vol. 21, Issue 45) Peer-ReviewedA wealth of cytogenetic data has demonstrated that numerous somatic genetic changes are involved in the pathogenesis of human lung cancer. Despite the complexity of the genomic changes observed in these neoplasms,...
- 11From: Oncogene. (Vol. 21, Issue 45) Peer-ReviewedFollowing two decades of research on the biology of cancer and in particular of lung cancer, we have now a large number of molecular targets that can be utilized to create specific medicines against these cancers....
- 12From: Oncogene. (Vol. 21, Issue 45) Peer-ReviewedLung cancer is the single most common cause of death, and almost all of it is due to tobacco smoking. Before the widespread use of cigarettes in this century, lung cancer was a rare illness. Tobacco smoke is a complex...
- 13From: Oncogene. (Vol. 21, Issue 45) Peer-ReviewedLoss of heterozygosity (LOH) involving several chromosome 3p regions accompanied by chromosome 3p deletions are detected in almost 100% of small (SCLCs) and more than 90% of non-small (NSCLCs) cell lung cancers. In...
- 14From: Oncogene. (Vol. 21, Issue 45) Peer-ReviewedChromosomal abnormality is one of the hallmarks of neoplastic cells, and the persistent presence of chromosome instability (CIN) has been demonstrated in human cancers, including lung cancer. Recent progress in...
- 15From: Oncogene. (Vol. 21, Issue 45) Peer-ReviewedThe genetic components of the RB:CDK:cyclin:p16 tumor suppressor pathway undergo mutational and epigenetic alterations in a wide range of human cancers and serve as critical targets for inactivation by the transforming...
- 16From: Oncogene. (Vol. 21, Issue 45) Peer-ReviewedDespite extensive effort in improvement of diagnosis and treatment of patients with lung cancer in past three decades, the overall survival of patients with the disease remains dismal. Because the development of lung...
- 17From: Oncogene. (Vol. 21, Issue 45) Peer-ReviewedCurrent approaches for the therapy of lung cancer, the majority of which being advanced cancers, have failed to impact on long term survival. The key to improvement lies in the combination of early diagnosis and the...
- 18From: Oncogene. (Vol. 21, Issue 45) Peer-ReviewedThe identification of a tumor suppressor gene in non-small cell lung cancer (NSCLC) is one of the most important issues to elucidate the molecular mechanisms of this type of refractory cancer and to establish a novel...