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- 1From: Oncogene. (Vol. 21, Issue 35) Peer-ReviewedAuthor(s): Peter A Jones Author Affiliations: Figure 1 Dr Peter A Jones, Director of the University of Southern California/Norris Comprehensive Cancer Center and Distinguished Professor of Biochemistry and Molecular...
- 2From: Oncogene. (Vol. 21, Issue 35) Peer-ReviewedAuthor(s): Egor Prokhortchouk 1 , Brian Hendrich 2 Author Affiliations: (1) Group of Transcriptional Control and Oncogenesis, Institute of Gene Biology, Moscow, Russian Federation (2) Centre for Genome Research,...
- 3From: Oncogene. (Vol. 21, Issue 35) Peer-ReviewedKnowledge about breast carcinogenesis has accumulated during the last decades but has barely been translated into strategies for early detection or prevention of this common disease. Changes in DNA methylation have been...
- 4From: Oncogene. (Vol. 21, Issue 35) Peer-ReviewedThere is tremendous ferment in the field of epigenetics as the relationships between chromatin structure and DNA methylation patterns become clearer. Central to this activity is the realization that the 'histone code',...
- 5From: Oncogene. (Vol. 21, Issue 35) Peer-ReviewedCancer-associated DNA hypomethylation is as prevalent as cancer-linked hypermethylation, but these two types of epigenetic abnormalities usually seem to affect different DNA sequences. Much more of the genome is...
- 6From: Oncogene. (Vol. 21, Issue 35) Peer-ReviewedDNA methylation alterations are now widely recognized as a contributing factor in human tumorigenesis. A significant number of tumor suppressor genes are transcriptionally silenced by promoter hypermethylation, and...
- 7From: Oncogene. (Vol. 21, Issue 35) Peer-ReviewedLittle it known about human stem cells although they are likely to be the earliest progenitors of carcinomas. Just as methylation can substitute for mutations to inactivate tumor suppressor genes, methylation can also...
- 8From: Oncogene. (Vol. 21, Issue 35) Peer-ReviewedThe DNA methylation pattern of a cell is exquisitely controlled during early development resulting in distinct methylation patterns. The tight control of DNA methylation is released in the cancer cell characterized by a...
- 9From: Oncogene. (Vol. 21, Issue 35) Peer-ReviewedRestriction landmark genomic scanning (RLGS) has been used to study DNA methylation in cancer for nearly a decade. The strong bias of RLGS for assessing the methylation state of CpG islands genome wide makes this an...
- 10From: Oncogene. (Vol. 21, Issue 35) Peer-ReviewedWe have come a long way since the first reports of the existence of aberrant DNA methylation in human cancer. Hypermethylation of CpG islands located in the promoter regions of tumor suppressor genes is now firmly...
- 11From: Oncogene. (Vol. 21, Issue 35) Peer-ReviewedMethylation of cytosines within the CpG dinucleotide by DNA methyltransferases is involved in regulating transcription and chromatin structure, controlling the spread of parasitic elements, maintaining genome stability...
- 12From: Oncogene. (Vol. 21, Issue 35) Peer-ReviewedAberrant gene silencing in mammalian cells is associated with promoter region methylation, but the sequence of these two events is not clear. This review will consider the possibility that gene silencing is not a single...
- 13From: Oncogene. (Vol. 21, Issue 35) Peer-ReviewedCarcinoma of the lung is the most common cause of cancer death worldwide. The estimated 5-year survival ranges from 6-16%, depending on the cell type. The best opportunity for improving survival of lung cancer patients...
- 14From: Oncogene. (Vol. 21, Issue 35) Peer-ReviewedThe laboratory mouse is one of the most powerful tools for both gene discovery and validation in cancer genetics. Recent technological advances in engineering the mouse genome with chromosome translocations, latent...
- 15From: Oncogene. (Vol. 21, Issue 35) Peer-Reviewed5-Azacytidine was first synthesized almost 40 years ago. It was demonstrated to have a wide range of anti-metabolic activities when tested against cultured cancer cells and to be an effective chemotherapeutic agent for...