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- 1From: Oncogene. (Vol. 21, Issue 34) Peer-ReviewedAuthor(s): Ana M Tari [1]; Soo-Jeong Lim [1]; Mien-Chie Hung [2]; Francisco J Esteva [3]; Gabriel Lopez-Berestein [1] All-trans retinoic acid (ATRA) inhibits the growth of various cell types. ATRA mediates its growth...
- 2From: Oncogene. (Vol. 21, Issue 34) Peer-ReviewedAuthor(s): Padmalatha Channavajhala [1]; David C Seldin [1, 2] Protein kinase CK2 (CK2, formerly casein kinase II) is a regulatory serine-threonine kinase that is ubiquitously expressed in cells and is highly conserved...
- 3From: Oncogene. (Vol. 21, Issue 34) Peer-ReviewedAuthor(s): Qin M Chen [1]; Jessica B Merrett [1]; Tarrah Dilley [1]; Sally Purdom [1] Cell death plays an important role in regulating tissue homeostasis. Programmed cell death takes place during the process of...
- 4From: Oncogene. (Vol. 21, Issue 34) Peer-ReviewedAuthor(s): Bryan L Betz [1]; Matthew W Strobeck [2]; David N Reisman [1]; Erik S Knudsen [2]; Bernard E Weissman [1] Chromatin remodeling complexes regulate gene expression by modulating access of transcription factors...
- 5From: Oncogene. (Vol. 21, Issue 34) Peer-Reviewedp53 is an important regulator of cell cycle progression and apoptosis, and inactivation of p53 is associated with tumorigenesis. Although p53 exerts many of its effects through regulation of transcription, this protein...
- 6From: Oncogene. (Vol. 21, Issue 34) Peer-ReviewedWe examined the effect of a constitutively active Raf protein (Raf-CAAX) on the differentiation and the coincident apoptosis of skeletal myoblasts. We found that a low level of Raf signaling leads to accelerated...
- 7From: Oncogene. (Vol. 21, Issue 34) Peer-ReviewedEngagement of the Granulocyte-Colony-Stimulating Factor (G-CSF) receptor activates non-receptor protein tyrosine kinases Lyn and Jak2. We found that Lyn-deficient DT40 cells that express the G-CSF receptor (DT40GR) do...
- 8From: Oncogene. (Vol. 21, Issue 34) Peer-ReviewedTemperature sensitive mutations in host cell factor 1 (HCF-1) arrest cells in the middle of the G1 phase of the cycle. We have shown that the highly conserved C-terminal WYF domain of HCF-1 protein interacts with the...
- 9From: Oncogene. (Vol. 21, Issue 34) Peer-ReviewedShedding of intercellular adhesion molecule 1 (ICAM-1) is believed to play a role in tumor cell resistance to cell-mediated cytotoxicity. However, the mechanism whereby ICAM-1 is shed from the surface of tumor cells...
- 10From: Oncogene. (Vol. 21, Issue 34) Peer-ReviewedSpectrins play a pivotal role in axonal transport, neurite extension, the organization of synaptic vesicles, as well as for protein sorting in the Golgi apparatus and cell membrane. Among spectrins there is great...
- 11From: Oncogene. (Vol. 21, Issue 34) Peer-ReviewedProthymosin [alpha] (PT[alpha]) is a small highly acidic protein found in the nuclei of virtually all mammalian tissues. Its high conservation in mammals and wide tissue distribution suggest an essential biological...
- 12From: Oncogene. (Vol. 21, Issue 34) Peer-ReviewedThe breast cancer suppressor protein, BRCA1 plays an important role in mediating cell cycle arrest, apoptosis and DNA responses to DNA damage signals. In this study, we show that BRCA1 level is downregulated during...
- 13From: Oncogene. (Vol. 21, Issue 34) Peer-ReviewedAnti-oxidant response element (ARE) and nuclear factors including Nrf2 and small Maf (MafG and MafK) proteins are known to regulate expression and induction of detoxifying enzyme genes including quinone oxidoreductase1...
- 14From: Oncogene. (Vol. 21, Issue 34) Peer-ReviewedReplication of DNA containing 8-oxo-7,8-dihydroguanine (8oxoG) can generate 8oxoG/A base pairs which, if uncorrected, lead to G[right arrow]T transversions. It is generally accepted that the repair of these promutagenic...
- 15From: Oncogene. (Vol. 21, Issue 34) Peer-ReviewedExpression of PTENtumor suppressor gene has been known to dephosphorylate the phosphatidylinositol 3[mu] kinase (PI3K) products on the 3 prime inositol ring, resulting in reduced Akt activation. Loss of PTEN expression...