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- 1From: Journal of Signal Transduction. Peer-ReviewedThe AP-1 transcription factor is a heterodimer protein that regulates gene expression in response to a variety of extrinsic stimuli through signal transduction. It is involved in processes including differentiation,...
- 2From: Journal of Signal Transduction. Peer-ReviewedChronic treatment with fluoxetine or other so-called serotonin-specific reuptake inhibitor antidepressants (SSRIs) or with a lithium salt "lithium", carbamazepine, or valproic acid, the three classical antibipolar...
- 3From: Journal of Signal Transduction. Peer-ReviewedProtein-tyrosine phosphorylation, which is catalyzed by protein-tyrosine kinase (PTK), plays a pivotal role in a variety of cellular functions related to health and disease. The discovery of the viral oncogene Src...
- 4From: Journal of Signal Transduction. Peer-ReviewedPhosphatase and tensin homologue (PTEN) is a critical cell endogenous inhibitor of phosphoinositide signaling in mammalian cells. PTEN dephosphorylates phosphoinositide trisphosphate ([PIP.sub.3]), and by so doing PTEN...
- 5From: Journal of Signal Transduction. Peer-ReviewedIntravenous immunoglobulin (IVIG), a highly purified immunoglobulin fraction prepared from pooled plasma of several thousand donors, increased anti-inflammatory cytokine IL-10 production, while decreased proinflammatory...
- 6From: Journal of Signal Transduction. Peer-ReviewedEstrogen and growth factors play a major role in uterine leiomyoma (UtLM) growth possibly through interactions of receptor tyrosine kinases (RTKs) and estrogen receptor-alpha (ER[alpha]) signaling. We determined the...
- 7From: Journal of Signal Transduction. Peer-ReviewedGliomas are the most common tumor in the central nervous system. High-grade glioblastomas are characterized by their high invasiveness and resistance to radiotherapy, leading to high recurrence rate and short median...
- 8From: Journal of Signal Transduction. Peer-ReviewedActivation of the growth hormone (GH) secretagogue receptor (GHS-R) by synthetic GH releasing peptides (GHRP) or its endogenous ligand (Ghrelin) stimulates GH release. Though much is known about the signal transduction...
- 9From: Journal of Signal Transduction. Peer-ReviewedA-kinase anchoring proteins (AKAPs) constitute a family of scaffolding proteins that contribute to spatiotemporal regulation of PKA-mediated phosphorylation events. In particular, AKAP7 is a family of alternatively...
- 10From: Journal of Signal Transduction. Peer-ReviewedIt is known that thyroid hormone is an important regulator of cancer development and metastasis. What is more, changes across the genome, as well as alternative splicing, may affect the activity of the thyroid hormone...
- 11From: Journal of Signal Transduction. Peer-ReviewedInflux of calcium through voltage-dependent channels regulates processes throughout the nervous system. Specifically, influx through L-type channels plays a variety of roles in early neuronal development and is commonly...
- 12From: Journal of Signal Transduction. Peer-Reviewed[alpha]-Fetoprotein (AFP) is known to be highly produced in fetal liver despite its barely detectable level in normal adult liver. On the other hand, hepatocellular carcinoma often shows high expression of AFP. Thus,...
- 13From: Journal of Signal Transduction. Peer-ReviewedThe physiological hydroelectrolytic balance and the redox steady state in the kidney are accomplished by an intricate interaction between signals from extrarenal and intrarenal sources and between antinatriuretic and...
- 14From: Journal of Signal Transduction. Peer-ReviewedDiabetes mellitus (DM) induces a large number of diseases of the nervous, cardiovascular, and some other systems of the organism. One of the main causes of the diseases is the changes in the functional activity of...
- 15From: Journal of Signal Transduction. Peer-ReviewedTEK tyrosine kinase is primarily expressed on endothelial cells and is most commonly referred to as TIE2. TIE2 is a receptor tyrosine kinase modulated by its ligands, angiopoietins, to regulate the development and...
- 16From: Journal of Signal Transduction. Peer-ReviewedPulmonary circulation is an important circulatory system in which the body brings in oxygen. Pulmonary arterial hypertension (PAH) is a progressive and fatal disease that predominantly affects women. Sustained pulmonary...
- 17From: Journal of Signal Transduction. Peer-ReviewedVentricular myocytes deficient in endothelial nitric oxide synthase ([NOS3.sup.-/-]) exhibit prolonged action potential (AP) duration and enhanced spontaneous activity (early and delayed afterdepolarizations) during...
- 18From: Journal of Signal Transduction. Peer-ReviewedInteractions between the extracellular matrix (ECM) and integrin receptors trigger structural and functional bonds between the cell microenvironment and the cytoskeleton. Such connections are essential for adhesion...