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- 1From: Oncogene. (Vol. 20, Issue 44) Peer-ReviewedAuthor(s): John R Bradley [1]; Jordan S Pober [2] Tumor necrosis factor receptor-associated factors (TRAFs) are a family of adaptor proteins that share a common structural domain at their C-terminus. This conserved...
- 2From: Oncogene. (Vol. 20, Issue 44) Peer-ReviewedAuthor(s): Alexander Y Tsygankov [1]; Anjali M Teckchandani [1]; Elena A Feshchenko [1]; Gayathri Swaminathan [1] CBL proteins and their domains The c-Cbl protooncogenic protein was initially identified as the...
- 3From: Oncogene. (Vol. 20, Issue 44) Peer-ReviewedAuthor(s): Scott A Weed [1]; J Thomas Parsons [2] Dynamic changes in the cortical actin cytoskeleton are central to a wide variety of cellular events, including cell motility, adhesion, endo- and phagocytosis,...
- 4From: Oncogene. (Vol. 20, Issue 44) Peer-ReviewedAuthor(s): Peter Wonerow [1]; Steve P Watson [1] Signal transduction events following engagement of immune receptors or receptor tyrosine kinases are crucially dependent on the formation of multiprotein complexes....
- 5From: Oncogene. (Vol. 20, Issue 44) Peer-ReviewedAuthor(s): James W Voltz [1]; Edward J Weinman [2]; Shirish Shenolikar [1] Identified nearly a decade ago as a protein cofactor necessary for cyclic AMP-mediated inhibition of the renal apical Na+ /H+ exchanger isoform...
- 6From: Oncogene. (Vol. 20, Issue 44) Peer-ReviewedAuthor(s): Stephan M Feller [1] Historical beginnings A chicken tumour sample originally collected in the 1930s by Albert Claude at the Rockefeller Institute in New York was finally, in the 1980s, 'recycled' by...
- 7From: Oncogene. (Vol. 20, Issue 44) Peer-ReviewedAuthor(s): Barbi A Judd [1, 2]; Gary A Koretzky [1, 2] Platelet activation is a required step in hemostasis following vascular injury. After binding to exposed ligands on the subendothelium, platelets change shape to...
- 8From: Oncogene. (Vol. 20, Issue 44) Peer-ReviewedAuthor(s): Joseph M Baisden [1]; Yong Qian [1]; Henry M Zot [2]; Daniel C Flynn [1] Early Studies of AFAP-110 The nonreceptor tyrosine kinase, Src, is a well-studied enzyme that has served as a model system for...
- 9From: Oncogene. (Vol. 20, Issue 44) Peer-ReviewedAuthor(s): Stanley K-W Liu [1]; Donna M Berry [1]; C Jane McGlade [1] The Grb2 family of adaptor proteins-Grb2, Grap, and Gads One of the best known and characterized adaptors is the evolutionarily conserved Grb2...
- 10From: Oncogene. (Vol. 20, Issue 44) Peer-ReviewedAuthor(s): Xosé R Bustelo [1] The evolutionary transition of unicellular to multicellular animal organisms coincided with the development of signal transduction pathways regulated by tyrosine phosphorylation events....
- 11From: Oncogene. (Vol. 20, Issue 44) Peer-ReviewedAuthor(s): Naohiro Inohara [1]; Gabriel Nuñez [1] Programmed cell death (PCD) or apoptosis plays a critical role not only during embryonic development and cellular homeostasis in the adult, but also in the clearance...
- 12From: Oncogene. (Vol. 20, Issue 44) Peer-ReviewedPaxillin is a focal adhesion-associated, phosphotyrosine-containing protein that may play a role in several signaling pathways. Paxillin contains a number of motifs that mediate protein-protein interactions, including...
- 13From: Oncogene. (Vol. 20, Issue 44) Peer-ReviewedEndocytosis is a regulated physiological process by which cell surface proteins are internalized along with extracellular factors such as nutrients, pathogens, peptides, toxins, etc. The process begins with the...
- 14From: Oncogene. (Vol. 20, Issue 44) Peer-ReviewedSpatial and temporal organization of signal transduction is essential in determining the speed and precision by which signaling events occur. Adaptor proteins are key to organizing signaling enzymes near their select...
- 15From: Oncogene. (Vol. 20, Issue 44) Peer-ReviewedThe adapter protein Shc was initially identified as an SH2 containing proto-oncogene involved in growth factor signaling. Since then a number of studies in multiple systems have implicated a role for Shc in signaling...
- 16From: Oncogene. (Vol. 20, Issue 44) Peer-ReviewedGrb7 family adaptor molecules consist of Grb7, Grb10 and Grb14, each of which has several splicing variants. Like other adaptor molecules, Grb7 family proteins function to mediate the coupling of multiple cell surface...
- 17From: Oncogene. (Vol. 20, Issue 44) Peer-Reviewed
Functions of the adapter protein Cas: signal convergence and the determination of cellular responses
Since Cas was first identified as a highly phosphorylated 130 kilodalton protein that associated with the v-Src and v-Crk-oncoproteins, considerable effort has been made to determine its function. Its predicted role as... - 18From: Oncogene. (Vol. 20, Issue 44) Peer-ReviewedThe 14-3-3 proteins are a part of an emerging family of proteins and protein domains that bind to serine/threonine-phosphorylated residues in a context specific manner, analogous to the Src homology 2 (SH2) and...
- 19From: Oncogene. (Vol. 20, Issue 44) Peer-ReviewedIn response to extracellular signals, cell surface receptors engage in connections with multiple intracellular signaling pathways, leading to the cellular responses such as survival, migration, proliferation and...