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- 1From: Nature Cell Biology. (Vol. 2, Issue 8) Peer-ReviewedAuthor(s): Qiaoming Long [1, 2, 3]; Haigen Huang [1, 3]; Ebrahim Shafizadeh [1, 3]; Ningai Liu [1]; Shuo Lin [1] Production of red blood cells is under both positive and negative control, and dysregulation of either of...
- 2From: Nature Cell Biology. (Vol. 2, Issue 8) Peer-ReviewedAuthor(s): Lan Xu [1]; Ye-Guang Chen [1]; Joan Massagué [1] Nuclear accumulation of Smad transcription factors in response to transforming growth factor β CTGFβ cytokines is triggered by TGFβ-receptor-mediated...
- 3From: Nature Cell Biology. (Vol. 2, Issue 8) Peer-ReviewedAuthor(s): Helen M. Beere [1]; Beni B. Wolf [1]; Kelvin Cain [2]; Dick D. Mosser [3]; Artin Mahboubi [1]; Tomomi Kuwana [1]; Pankaj Tailor [4]; Richard I. Morimoto [6]; Gerald M. Cohen [2]; Douglas R. Green [1]...
- 4From: Nature Cell Biology. (Vol. 2, Issue 8) Peer-ReviewedAuthor(s): Brad Amos (corresponding author) [1] According to conventional wisdom, the compound microscope was invented at the beginning of the seventeenth century and made possible the immediate discovery of cells....
- 5From: Nature Cell Biology. (Vol. 2, Issue 8) Peer-ReviewedAuthor(s): Dan Lin [1, 2]; Amelia S. Edwards [3]; James P. Fawcett [1]; Geraldine Mbamalu [1]; John D. Scott [3]; Tony Pawson [1, 2] Cellular polarity is critical to the development and function of many cell types....
- 6From: Nature Cell Biology. (Vol. 2, Issue 8) Peer-ReviewedHe imaginative power of nature certainly could not have produced anything more flexible than the cell to account for every complex morphology of the organic world. In the same way that the seven notes of the scale...
- 7From: Nature Cell Biology. (Vol. 2, Issue 8) Peer-ReviewedPAR (partitioning-defective) proteins, which were first identified in the nematode Caenorhabditis elegans, are essential for asymmetric cell division and polarized growth, whereas Cdc42 mediates establishment of cell...
- 8From: Nature Cell Biology. (Vol. 2, Issue 8) Peer-ReviewedAuthor(s): Sarah Greaves [1] The epithelial membranes of any organism consist of cells that have a regular columnar shape and defined apical-basolateral polarity. During carcinogenesis, epithelial cells lose these...
- 9From: Nature Cell Biology. (Vol. 2, Issue 8) Peer-ReviewedThe multisubunit protein complex cohesin is required to establish cohesion between sister chromatids during S phase and to maintain it during G2 and M phases. Cohesin is essential for mitosis, and even partial defects...
- 10From: Nature Cell Biology. (Vol. 2, Issue 8) Peer-ReviewedThree recent papers have reported the surprising finding that Cdc42 and Rac1, both of which are known to be involved in maintaining apico-basolateral polarity of epithelial cells, can each bind to a protein complex...
- 11From: Nature Cell Biology. (Vol. 2, Issue 8) Peer-ReviewedPhosphatidylinositol bisphosphate (PIP[sub.2]) directly regulates functions as diverse as the organization of the cytoskeleton, vesicular transport and ion channel activity. It is not known, however, whether dynamic...
- 12From: Nature Cell Biology. (Vol. 2, Issue 8) Peer-ReviewedIon channels are 'tunnel' proteins that allow the passive flow of mostly inorganic ions across otherwise extremely hydrophobic membranes. This flow can occur at extrordinary high flux rates, despite an often very high...
- 13From: Nature Cell Biology. (Vol. 2, Issue 8) Peer-ReviewedAuthor(s): Andrew Bloecher [1, 2]; Guglielmo M. Venturi [1]; Kelly Tatchell [1] Surveillance of the ordered process of mitosis in budding yeast is carried out by the spindle/kinetochore checkpoint, which was...
- 14From: Nature Cell Biology. (Vol. 2, Issue 8) Peer-ReviewedUbiquitin functions by covalently modifying other proteins. In the past few years, a surprising number of other proteins have been identified that, despite often being only slightly similar to ubiquitin, can also be...
- 15From: Nature Cell Biology. (Vol. 2, Issue 8) Peer-ReviewedThe fruitless gene governs courtship in male, but not female, Drosophila, yet it is expressed and specifically spliced in the brains of both sexes. New experiments reveal that a splice-recognition site retained in the...
- 16From: Nature Cell Biology. (Vol. 2, Issue 8) Peer-ReviewedMotility requires protrusive activity at the cellular edge, where Rho family members regulate actin dynamics. Here we show that p95-APP1 (ArfGAP-putative, Pix-interacting, paxillin-interacting protein 1), a member of...
- 17From: Nature Cell Biology. (Vol. 2, Issue 8) Peer-ReviewedAuthor(s): Mitsuyoshi Saito [1]; Stanley J. Korsmeyer [2]; Paul H. Schlesinger [1] Selected death signals activate pro-apoptotic BAX, resulting in translocation to mitochondria where it is inserted as an integral,...
- 18From: Nature Cell Biology. (Vol. 2, Issue 8) Peer-ReviewedBefore the advent of reverse genetics and genomics, cloning a gene or a complementary DNA was often the most difficult and time-consuming part of a project. This is no longer the rate-limiting step, however, now that a...
- 19From: Nature Cell Biology. (Vol. 2, Issue 8) Peer-ReviewedRelease of cytochrome c from mitochondria by apoptotic signals induces ATP/dATP-dependent formation of the oligomeric Apaf-1-caspase-9 apoptosome. Here we show that the documented anti-apoptotic effect of the principal...
- 20From: Nature Cell Biology. (Vol. 2, Issue 8) Peer-ReviewedHere we show that suppression of synthesis of the microtubule motor CENP-E (centromere-associated protein E), a component of the kinetochore corona fibres of mammalian centromeres, yields chromosomes that are...