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- 1From: Nature Cell Biology. (Vol. 2, Issue 5) Peer-ReviewedAuthor(s): David J. Sieg [1, 2]; Christof R. Hauck [1, 2]; Dusko Ilic [3]; Candice K. Klingbeil [1]; Erik Schaefer [4]; Caroline H. Damsky [3]; David D. Schlaepfer (corresponding author) [1] Transmembrane integrins...
- 2From: Nature Cell Biology. (Vol. 2, Issue 5) Peer-ReviewedAuthor(s): Xuri Li [1]; Annica Pontén [1]; Karin Aase [1]; Linda Karlsson [2]; Alexandra Abramsson [2]; Marko Uutela [3]; Gudrun Bäckström [4]; Mats Hellström [2]; Hans Boström [2]; Hong Li [1]; Philippe Soriano...
- 3From: Nature Cell Biology. (Vol. 2, Issue 5) Peer-Reviewed
The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho.
Author(s): Richard F. Lamb (corresponding author) [1]; Christian Roy [2]; Tom J. Diefenbach [4]; Harry V. Vinters [3]; Michael W. Johnson [3]; Daniel G. Jay [4]; Alan Hall [1] Hereditary cancer-predisposition syndromes... - 4From: Nature Cell Biology. (Vol. 2, Issue 5) Peer-ReviewedAuthor(s): Inge The; Norbert Perrimon (corresponding author) One of the unifying goals of developmental biology is the identification of a set of evolutionarily conserved, secreted molecules that are involved in the...
- 5From: Nature Cell Biology. (Vol. 2, Issue 5) Peer-ReviewedAuthor(s): Craig Montell (corresponding author) [1] The responses of animals to external stimuli, such as light and odours, are initiated with great speed through the engagement of G-protein-coupled signalling...
- 6From: Nature Cell Biology. (Vol. 2, Issue 5) Peer-ReviewedAlthough the nucleus appears to contain structural domains, little is understood regarding the components that constitute these regions. Now, a new protein, EAST, has been shown to be involved in the assembly of an...
- 7From: Nature Cell Biology. (Vol. 2, Issue 5) Peer-ReviewedAuthor(s): Angela Eggleston [1] Gap junctions facilitate the exchange of solutes, metabolic precursors and electrical currents between neighbouring cells. They appear as clusters (or plaques) of tightly packed...
- 8From: Nature Cell Biology. (Vol. 2, Issue 5) Peer-ReviewedA newly discovered platelet-derived growth factor (PDGF) isoform, PDGF-CC, is expressed in the mouse kidney during development, at a time and location distinct from those of the other two known PDGFs. These findings, as...
- 9From: Nature Cell Biology. (Vol. 2, Issue 5) Peer-ReviewedThe high degree of structural order inside the nucleus suggests the existence of an internal nucleoskeleton. Our studies on the east gene of Drosophila, using the larval salivary gland polytene nucleus as a model,...
- 10From: Nature Cell Biology. (Vol. 2, Issue 5) Peer-ReviewedThis issue marks the first anniversary of Nature Cell Biology . It gives us the opportunity to look back on what the journal has achieved so far, and to look ahead to the future of the field of cell biology and the...
- 11From: Nature Cell Biology. (Vol. 2, Issue 5) Peer-ReviewedThe movement of proteins within the nucleus can occur by diffusion, with surprisingly extensive and rapid turnover occurring in high-affinity intranuclear compartments. The transport of the proteins so far investigated...
- 12From: Nature Cell Biology. (Vol. 2, Issue 5) Peer-ReviewedThe PML gene encodes a tumour suppressor protein associated with a distinct subnuclear domain, the nuclear body. Various functions have been attributed to the PML nuclear body, but its main biochemical role is still...
- 13From: Nature Cell Biology. (Vol. 2, Issue 5) Peer-ReviewedIn Drosophila photoreceptors, phospholipase C (PLC) and other signalling components form multiprotein structures through the PDZ scaffold protein INAD. Association between PLC and INAD is important for termination of...
- 14From: Nature Cell Biology. (Vol. 2, Issue 5) Peer-ReviewedAlthough the importance of cell growth for cell-cycle progression has been recognized for thirty years, the molecular basis of this relationship is poorly understood. However, researchers have begun to tease apart these...
- 15From: Nature Cell Biology. (Vol. 2, Issue 5) Peer-ReviewedAuthor(s): Valerie Depraetere [1] Peptides derived from cellular proteins are continuously exposed at the cell surface, in association with MHC class I molecules. Recognition of these MHC-peptide complexes by...
- 16From: Nature Cell Biology. (Vol. 2, Issue 5) Peer-ReviewedKinesin undergoes a global folding conformational change from an extended active conformation at high ionic concentrations to a compact inhibited conformation at physiological ionic concentrations. Here we show that...
- 17From: Nature Cell Biology. (Vol. 2, Issue 5) Peer-ReviewedAuthor(s): Maximilien Murone [1, 2]; Shiuh-Ming Luoh [1]; Donna Stone [3]; Wenlu Li [4]; Austin Gurney [3]; Mark Armanini [3]; Christa Grey [3]; Arnon Rosenthal [3]; Frederic J. de Sauvage (corresponding author) [1]...
- 18From: Nature Cell Biology. (Vol. 2, Issue 5) Peer-ReviewedWhen co-translationally inserted into endoplasmic reticulum (ER) membranes, newly synthesized proteins encounter the lumenal environment of the ER, which contains chaperone proteins that facilitate the folding reactions...
- 19From: Nature Cell Biology. (Vol. 2, Issue 5) Peer-ReviewedIt has long been known that microtubule depletion causes axons to retract in a microfilament-dependent manner, although it was not known whether these effects are the result of motor-generated forces on these...
- 20From: Nature Cell Biology. (Vol. 2, Issue 5) Peer-ReviewedSphingosylphosphorylcholine (SPC) is a bioactive lipid that acts as an intracellular and extracellular signalling molecule in numerous biological processes. Many of the cellular actions of SPC are believed to be...