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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 2AndIssue Number: 4AndStart Page: e51AndDate: 2006 Revise Search
- 1From: PLoS Genetics. (Vol. 2, Issue 4) Peer-ReviewedA bold new effort to disrupt every gene in the mouse genome necessitates systematic, interdisciplinary approaches to analyzing patterning defects in the mouse embryo. We present a novel, rapid, and inexpensive method for...
- 2From: PLoS Genetics. (Vol. 2, Issue 4) Peer-ReviewedRIKEN's FANTOM project has revealed many previously unknown coding sequences, as well as an unexpected degree of variation in transcripts resulting from alternative promoter usage and splicing. Ever more transcripts that...
- 3From: PLoS Genetics. (Vol. 2, Issue 4) Peer-ReviewedThere is increasing evidence in both plants and animals that epigenetic marks are not always cleared between generations. Incomplete erasure at genes associated with a measurable phenotype results in unusual patterns of...
- 4From: PLoS Genetics. (Vol. 2, Issue 4) Peer-ReviewedMammalian genomes harbor a larger than expected number of complex loci, in which multiple genes are coupled by shared transcribed regions in antisense orientation and/or by bidirectional core promoters. To determine the...
- 5From: PLoS Genetics. (Vol. 2, Issue 4) Peer-ReviewedABSTRACT The international FANTOM consortium aims to produce a comprehensive picture of the mammalian transcriptome, based upon an extensive cDNA collection and functional annotation of full-length enriched cDNAs. The...
- 6From: PLoS Genetics. (Vol. 2, Issue 4) Peer-ReviewedNon-protein-coding RNAs (ncRNAs) are increasingly being recognized as having important regulatory roles. Although much recent attention has focused on tiny 22- to 25-nucleotide microRNAs, several functional ncRNAs are...
- 7From: PLoS Genetics. (Vol. 2, Issue 4) Peer-ReviewedBecause of the widespread phenomenon of patrilocality, it is hypothesized that Y-chromosome variants tend to be more localized geographically than those of mitochondrial DNA (mtDNA). Empirical evidence confirmatory to...
- 8From: PLoS Genetics. (Vol. 2, Issue 4) Peer-ReviewedGene amplification is a collection of processes whereby a DNA segment is reiterated to multiple copies per genome. It is important in carcinogenesis and resistance to chemotherapeutic agents, and can underlie adaptive...
- 9From: PLoS Genetics. (Vol. 2, Issue 4) Peer-ReviewedMembrane organization describes the orientation of a protein with respect to the membrane and can be determined by the presence, or absence, and organization within the protein sequence of two features: endoplasmic...
- 10From: PLoS Genetics. (Vol. 2, Issue 4) Peer-ReviewedUsing the two largest collections of Mus musculus and Homo sapiens transcription start sites (TSSs) determined based on CAGE tags, ditags, full-length cDNAs, and other transcript data, we describe the compositional...
- 11From: PLoS Genetics. (Vol. 2, Issue 4) Peer-ReviewedABSTRACT Our understanding of balancing selection is currently becoming greatly clarified by new sequence data being gathered from genes in which polymorphisms are known to be maintained by selection. The data can be...
- 12From: PLoS Genetics. (Vol. 2, Issue 4) Peer-ReviewedIn this first application of the approximate Bayesian computation approach using the serial coalescent, we demonstrated the estimation of historical demographic parameters from ancient DNA. We estimated the timing and...
- 13From: PLoS Genetics. (Vol. 2, Issue 4) Peer-ReviewedOne of the most common splice variations are small exon length variations caused by the use of alternative donor or acceptor splice sites that are in very close proximity on the pre-mRNA. Among these, three-nucleotide...
- 14From: PLoS Genetics. (Vol. 2, Issue 4) Peer-ReviewedWe have investigated the role of DNA methylation in the initiation and maintenance of silenced chromatin in somatic mammalian cells. We found that a mutated transgene, in which all the CpG dinucleotides have been...
- 15From: PLoS Genetics. (Vol. 2, Issue 4) Peer-ReviewedMultiple endocrine neoplasia type I (MEN1) is a familial cancer syndrome characterized primarily by tumors of multiple endocrine glands. The gene for MEN1 encodes a ubiquitously expressed tumor suppressor protein called...
- 16From: PLoS Genetics. (Vol. 2, Issue 4) Peer-ReviewedATRX is an X-encoded member of the SNF2 family of ATPase/helicase proteins thought to regulate gene expression by modifying chromatin at target loci. Mutations in ATRX provided the first example of a human genetic...
- 17From: PLoS Genetics. (Vol. 2, Issue 4) Peer-ReviewedRecent large-scale cDNA sequencing efforts show that elaborate patterns of splice variation are responsible for much of the proteome diversity in higher eukaryotes. To obtain an accurate account of the repertoire of...
- 18From: PLoS Genetics. (Vol. 2, Issue 4) Peer-ReviewedShort proteins play key roles in cell signalling and other processes, but their abundance in the mammalian proteome is unknown. Current catalogues of mammalian proteins exhibit an artefactual discontinuity at a length...
- 19From: PLoS Genetics. (Vol. 2, Issue 4) Peer-ReviewedThe mammalian transcriptome harbours shadowy entities that resist classification and analysis. In analogy with pseudogenes, we define pseudo-messenger RNA to be RNA molecules that resemble protein-coding mRNA, but...
- 20From: PLoS Genetics. (Vol. 2, Issue 4) Peer-ReviewedDOI: 10.1371/journal.pgen.0010065 In PLoS Genetics, volume 1, issue 5: The list of contributing authors does not include Daniel H. Haft, whose name should have appeared between James F. Kolonay and William C....