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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 2AndIssue Number: 10AndStart Page: e168AndDate: 2006 Revise Search
- 1From: PLoS Genetics. (Vol. 2, Issue 10) Peer-ReviewedThe Ran-binding protein 2 (RanBP2) is a large multimodular and pleiotropic protein. Several molecular partners with distinct functions interacting specifically with selective modules of RanBP2 have been identified. Yet,...
- 2From: PLoS Genetics. (Vol. 2, Issue 10) Peer-ReviewedComparative genomics allow us to search the human genome for segments that were extensively changed in the last ~5 million years since divergence from our common ancestor with chimpanzee, but are highly conserved in...
- 3From: PLoS Genetics. (Vol. 2, Issue 10) Peer-ReviewedGenomic imprinting, representing parent-specific expression of alleles at a locus, raises many questions about how--and especially why--epigenetic silencing of mammalian genes evolved. We present the first in-depth study...
- 4From: PLoS Genetics. (Vol. 2, Issue 10) Peer-ReviewedMitochondria carry out specialized functions; compartmentalized, yet integrated into the metabolic and signaling processes of the cell. Although many mitochondrial proteins have been identified, understanding their...
- 5From: PLoS Genetics. (Vol. 2, Issue 10) Peer-ReviewedKallmann syndrome combines anosmia, related to defective olfactory bulb morphogenesis, and hypogonadism due to gonadotropin-releasing hormone deficiency. Loss-of-function mutations in KAL1 and FGFR1 underlie the X...
- 6From: PLoS Genetics. (Vol. 2, Issue 10) Peer-ReviewedOtitis media (OM), inflammation of the middle ear, remains the most common cause of hearing impairment in children. It is also the most common cause of surgery in children in the developed world. There is evidence from...
- 7From: PLoS Genetics. (Vol. 2, Issue 10) Peer-ReviewedThe maize Activator/Dissociation (Ac/Ds) elements are members of the hAT (hobo, Ac, and Tam3) superfamily of type II (DNA) transposons that transpose through a "cut-and-paste" mechanism. Previously, we reported that a...
- 8From: PLoS Genetics. (Vol. 2, Issue 10) Peer-ReviewedABSTRACT The International HapMap Project and the arrival of technologies that type more than 100,000 SNPs in a single experiment have made genome-wide single nucleotide polymorphism (GW-SNP) assay a realistic...
- 9From: PLoS Genetics. (Vol. 2, Issue 10) Peer-ReviewedThe phylogenetic relationship of the now fully sequenced species Drosophila erecta and D. yakuba with respect to the D. melanogaster species complex has been a subject of controversy. All three possible groupings of the...
- 10From: PLoS Genetics. (Vol. 2, Issue 10) Peer-ReviewedTransposable elements are potent agents of genomic change during evolution, but require access to chromatin for insertion--and not all genes provide equivalent access. To test whether the regulatory features of...
- 11From: PLoS Genetics. (Vol. 2, Issue 10) Peer-ReviewedVariation in gene expression is heritable and has been mapped to the genome in humans and model organisms as expression quantitative trait loci (eQTLs). We applied integrated genome-wide expression profiling and linkage...
- 12From: PLoS Genetics. (Vol. 2, Issue 10) Peer-ReviewedSize control is essential for all proliferating cells, and is thought to be regulated by checkpoints that couple cell size to cell cycle progression. The aberrant cell-size phenotypes caused by mutations in the...
- 13From: PLoS Genetics. (Vol. 2, Issue 10) Peer-ReviewedAn important goal of population genetics is to determine the forces that have shaped the pattern of genetic variation in natural populations. We developed a maximum likelihood method that allows us to infer demographic...
- 14From: PLoS Genetics. (Vol. 2, Issue 10) Peer-ReviewedTraditionally, programmed cell death (PCD) is associated with eukaryotic multicellular organisms. However, recently, PCD systems have also been observed in bacteria. Here we review recent research on two kinds of...
- 15From: PLoS Genetics. (Vol. 2, Issue 10) Peer-ReviewedAlthough a large proportion of human transcription occurs outside the boundaries of known genes, the functional significance of this transcription remains unknown. We have compared the expression patterns of known genes...
- 16From: PLoS Genetics. (Vol. 2, Issue 10) Peer-ReviewedUsing data from primates, we show that molecular clocks in sites that have been part of a CpG dinucleotide in recent past (CpG sites) and non-CpG sites are of markedly different nature, reflecting differences in their...