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- Search Terms:ISSN: 1553734XAndISSN: 15537358AndVolume Number: 2AndIssue Number: 10AndStart Page: e125AndDate: 2006 Revise Search
- 1From: PLoS Computational Biology. (Vol. 2, Issue 10) Peer-ReviewedDeleterious mutations are considered a major impediment to adaptation, and there are straightforward expectations for the rate at which they accumulate as a function of population size and mutation rate. In a simulation...
- 2From: PLoS Computational Biology. (Vol. 2, Issue 10) Peer-ReviewedThe central circadian pacemaker is located in the hypothalamus of mammals, but essentially the same oscillating system operates in peripheral tissues and even in immortalized cell lines. Using luciferase reporters that...
- 3From: PLoS Computational Biology. (Vol. 2, Issue 10) Peer-ReviewedLike most scientists, annotators at the Research Collaboratory for Structural Bioinformatics (RCSB) (http://www.pdb.org) dread the immortal cocktail party question "So, what do you do?" Unlike for some jobs, however,...
- 4From: PLoS Computational Biology. (Vol. 2, Issue 10) Peer-ReviewedEfforts in structural biology have targeted the systematic determination of all protein structures through experimental determination or modeling. In recent years, 3-D electron cryomicroscopy (cryoEM) has assumed an...
- 5From: PLoS Computational Biology. (Vol. 2, Issue 10) Peer-ReviewedHow do individual epithelial cells (ECs) organize into multicellular structures? ECs are studied in vitro to help answer that question. Characteristic growth features include stable cyst formation in embedded culture,...
- 6From: PLoS Computational Biology. (Vol. 2, Issue 10) Peer-ReviewedPathogens that evolve resistance to drugs usually have reduced fitness. However, mutations that largely compensate for this reduction in fitness often arise. We investigate how these compensatory mutations affect...
- 7From: PLoS Computational Biology. (Vol. 2, Issue 10) Peer-ReviewedModular polyketide synthases (PKSs) of bacteria provide an enormous reservoir of natural chemical diversity. Studying natural biocombinatorics may aid in the development of concepts for experimental design of genes for...
- 8From: PLoS Computational Biology. (Vol. 2, Issue 10) Peer-ReviewedConventional evolutionary game theory predicts that natural selection favours the selfish and strong even though cooperative interactions thrive at all levels of organization in living systems. Recent investigations...
- 9From: PLoS Computational Biology. (Vol. 2, Issue 10) Peer-ReviewedIt is becoming increasingly clear that nuclear macromolecules and macromolecular complexes are compartmentalized through binding interactions into an apparent three-dimensionally ordered structure. This ordering,...
- 10From: PLoS Computational Biology. (Vol. 2, Issue 10) Peer-ReviewedComputational biology is a discipline built upon data (mostly free access), found in biological databases, and knowledge (mostly not free access), found in the literature. So important are these online sources of data...
- 11From: PLoS Computational Biology. (Vol. 2, Issue 10) Peer-ReviewedThe gain and loss of functional transcription factor binding sites has been proposed as a major source of evolutionary change in cis-regulatory DNA and gene expression. We have developed an evolutionary model to study...
- 12From: PLoS Computational Biology. (Vol. 2, Issue 10) Peer-ReviewedFrom Impressionism and Pop Art to phosphorylation sites and interacting atom pairs, the realm of curation has been expanded. The recent growth of bioinformatics, driven by exponentially growing data, advanced computing...
- 13From: PLoS Computational Biology. (Vol. 2, Issue 10) Peer-ReviewedBiological organisms continuously select and sample information used by their neural structures for perception and action, and for creating coherent cognitive states guiding their autonomous behavior. Information...
- 14From: PLoS Computational Biology. (Vol. 2, Issue 10) Peer-ReviewedDespite many years of potent antiretroviral therapy, latently infected cells and low levels of plasma virus have been found to persist in HIV-infected patients. The factors influencing this persistence and their relative...
- 15From: PLoS Computational Biology. (Vol. 2, Issue 10) Peer-ReviewedDOI: 10.1371/journal.pcbi.0020085 In PLoS Computational Biology, volume 2, issue 7: The references to the figure parts in the legend of figure 3 were incorrect. The correct caption is as follows: Figure 3. The...