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- 1From: Nature Cell Biology. (Vol. 2, Issue 10) Peer-ReviewedAuthor(s): Gabriele Bergers [1, 4]; Rolf Brekken [6]; Gerald McMahon [7]; Thiennu H. Vu [2]; Takeshi Itoh [8, 12]; Kazuhiko Tamaki [9]; Kazuhiko Tanzawa [9]; Philip Thorpe [10]; Shigeyoshi Itohara [11]; Zena Werb [3, 5];...
- 2From: Nature Cell Biology. (Vol. 2, Issue 10) Peer-ReviewedAuthor(s): Shuji Hinuma (corresponding author) [1]; Yasushi Shintani [1]; Shoji Fukusumi [1]; Norio Iijima [2]; Yoshio Matsumoto [1]; Masaki Hosoya [1]; Ryo Fujii [1]; Takuya Watanabe [1]; Kuniko Kikuchi [1]; Yasuko...
- 3From: Nature Cell Biology. (Vol. 2, Issue 10) Peer-ReviewedAuthor(s): Roberta Melchionna [1]; Xiao-Bo Chen [1]; Alessandra Blasina [1, 2]; Clare H. McGowan (corresponding author) [1] In response to DNA damage, eukaryotic cells use a system of checkpoint controls to delay...
- 4From: Nature Cell Biology. (Vol. 2, Issue 10) Peer-ReviewedAuthor(s): Michael Lutter [1]; Min Fang [1]; Xu Luo [1]; Masahiro Nishijima [3]; Xiao-song Xie [2]; Xiaodong Wang (corresponding author) [1] Recent evidence supports the theory that mitochondrial homeostasis is the key...
- 5From: Nature Cell Biology. (Vol. 2, Issue 10) Peer-ReviewedAuthor(s): Rainer Strotmann [1]; Christian Harteneck [1]; Karin Nunnenmacher [1]; Günter Schultz [1]; Tim D. Plant (corresponding author) [1] OSM-9, a putative TRP-like channel protein from...
- 6From: Nature Cell Biology. (Vol. 2, Issue 10) Peer-ReviewedAuthor(s): Thomas Marty [1, 3]; Bruno Müller [3, 2]; Konrad Basler [3]; Markus Affolter (corresponding author) [1] Signalling molecules of the transforming growth factor-β (TGF-β) superfamily regulate numerous...
- 7From: Nature Cell Biology. (Vol. 2, Issue 10) Peer-ReviewedAuthor(s): Andrei Smertenko [1, 6]; Norihan Saleh [1]; Hisako Igarashi [1, 6, 2]; Hitoshi Mori [3]; Isolde Hauser-Hahn [4]; Chang-Jie Jiang [1]; Seiji Sonobe [2]; Clive W. Lloyd [5]; Patrick J. Hussey (corresponding...
- 8From: Nature Cell Biology. (Vol. 2, Issue 10) Peer-ReviewedAuthor(s): Chris Marshall [1] Signal transduction has been pivotal in our understanding of normal cellular processes. During the last 20 years many of the molecules that transmit signals across the plasma membrane to...
- 9From: Nature Cell Biology. (Vol. 2, Issue 10) Peer-ReviewedMotor proteins such as kinesin, myosin and polymerase convert chemical energy into work through a cycle that involves nucleotide hydrolysis. Kinetic rates in the cycle that depend upon load identify transitions at which...
- 10From: Nature Cell Biology. (Vol. 2, Issue 10) Peer-ReviewedAuthor(s): Vania Braga [1] The small GTPases of the RHO subfamily (Rho, Rac and Cdc42) are signalling molecules that are primarily involved in remodelling of the cytoskeleton [1]. There is a great deal of interest in...
- 11From: Nature Cell Biology. (Vol. 2, Issue 10) Peer-ReviewedThe ncd protein is a dimeric, ATP-powered motor that belongs to the kinesin family of microtubule motor proteins. Here we resolve single mechanochemical cycles of recombinant, dimeric, full-length ncd, using...
- 12From: Nature Cell Biology. (Vol. 2, Issue 10) Peer-ReviewedAuthor(s): John C. Reed [1]; Shigemi Matsuyama [1]; Quinn L. Deveraux [1]; Juan Llopis [2]; Roger Tsien [3] To the editor This is a thoughtful critique of our work and we share the belief in the laws of...
- 13From: Nature Cell Biology. (Vol. 2, Issue 10) Peer-ReviewedWe are all stirred in one way or another by the 'spark of life', an emotive topic that has occupied man throughout the ages. How can we contemplate a world of some 4 billion years ago at the very creation of the earth...
- 14From: Nature Cell Biology. (Vol. 2, Issue 10) Peer-ReviewedPhagocytosis is the uptake of large particles by cells by a mechanism that is based on local rearrangement of the actin microfilament cytoskeleton. In higher organisms, phagocytic cells are essential for host defence...
- 15From: Nature Cell Biology. (Vol. 2, Issue 10) Peer-ReviewedThe p21-activated kinases (PAKs) are effectors for the Rho-family GTPase Cdc42p. Here we define the in vivo function of the kinase activity of the budding yeast PAK Cla4p, using cla4 alleles that are specifically...
- 16From: Nature Cell Biology. (Vol. 2, Issue 10) Peer-ReviewedAuthor(s): Hans Clevers [1] [beta]-catenin/Armadillo is at the centre of the Wnt/Wingless signalling pathway and, without activation of this pathway, is constitutively degraded by a multiprotein complex containing...
- 17From: Nature Cell Biology. (Vol. 2, Issue 10) Peer-ReviewedAuthor(s): Doug Kellogg [1] Thus far, our understanding of how protein kinases function in vivo has come largely from the analysis of phenotypes caused by conditional mutations, gene deletions or regulated...
- 18From: Nature Cell Biology. (Vol. 2, Issue 10) Peer-ReviewedAuthor(s): David Nicholls [1]; Paolo Bernardi [2]; Martin Brand [3]; Andrew Halestrap [4]; John Lemasters [5]; Ian Reynolds [6] To the editor The 'chemiosmotic hypothesis', formulated in the 1960s, revolutionized...
- 19From: Nature Cell Biology. (Vol. 2, Issue 10) Peer-ReviewedAuthor(s): Karen H. Vousden [1]; George F. Vande Woude [2] Like the parents of adolescent children, cell biologists routinely ask their favourite protein questions like "who are you hanging around with?" and "where...
- 20From: Nature Cell Biology. (Vol. 2, Issue 10) Peer-ReviewedAuthor(s): Sarah Greaves During cell division, essential chromosome and microtubule interactions occur that segregate the chromosomes into two sets. This is a tightly controlled process that functions to prevent...