Showing Results for
- Academic Journals (8)
Search Results
- 8
Academic Journals
- 8
- Search Terms:
- 1From: Silence. (Vol. 2) Peer-ReviewedThe study of miRNAs and other noncoding RNAs has revolutionised our understanding of gene expression regulation during cancer development and progression, creating one of the fastest-growing research fields in cancer...
- 2From: Silence. (Vol. 2) Peer-ReviewedShortly after their discovery, repertoires of miRNA were identified, together with proteins involved in their biogenesis and action. It is now obvious that miRNA-mediated gene regulation itself is regulated at multiple...
- 3From: Silence. (Vol. 2) Peer-ReviewedBackground Small interfering RNAs (siRNAs) are double-stranded RNAs that effectively inhibit expression of its complimentary target mRNA. Standard siRNAs contain two nucleotide overhangs on their 3' end. While these...
- 4From: Silence. (Vol. 2) Peer-ReviewedBackground RNA interference (RNAi) screens have been used to identify novel components of signal-transduction pathways in a variety of organisms. We performed a small interfering (si)RNA screen for novel members of...
- 5From: Silence. (Vol. 2) Peer-ReviewedPrior to the advent of new, deep sequencing methods, small RNA (sRNA) discovery was dependent on Sanger sequencing, which was time-consuming and limited knowledge to only the most abundant sRNA. The innovation of...
- 6From: Silence. (Vol. 2) Peer-ReviewedFor the past five years, evidence has accumulated that vector-mediated robust RNA interference (RNAi) expression can trigger severe side effects in small and large animals, from cytotoxicity and accelerated...
- 7From: Silence. (Vol. 2) Peer-ReviewedBackground MicroRNA (miRNA) are diverse in sequence and have a single known sequence bias: they tend to start with uridine (U). Results Our analyses of fly, worm and mouse miRNA sequence data reveal that the...
- 8From: Silence. (Vol. 2) Peer-ReviewedBackground MicroRNAs, post-transcriptional regulators of eukaryotic gene expression, are implicated in host defense against pathogens. Viruses and bacteria have evolved strategies that suppress microRNA functions,...