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- 1From: Stem Cell Research & Therapy. (Vol. 2) Peer-ReviewedIntroduction Local synthesis of interferon within B16 tumors mediates anti-tumor effects. Based on reports that stem cells are recruited to tumors, and because systemic administration of interferon causes dose-limiting...
- 2From: Stem Cell Research & Therapy. (Vol. 2) Peer-ReviewedIntroduction Tendon injury is a common problem in athletes, with poor tissue regeneration and a high rate of re-injury. Stem cell therapy is an attractive treatment modality as it may induce tissue regeneration rather...
- 3From: Stem Cell Research & Therapy. (Vol. 2, Issue 30) Peer-ReviewedWong and Reiter have explored the possibility that hair follicle stem cells can give rise to basal cell carcinoma (BCC). They expressed in mice an inducible human BCC-derived oncogenic allele of Smoothened, SmoM2, under...
- 4From: Stem Cell Research & Therapy. (Vol. 2) Peer-ReviewedIntroduction End-stage renal disease (ESRD) is a major public health problem. Although kidney transplantation is a viable therapeutic option, this therapy is associated with significant limitations, including a...
- 5From: Stem Cell Research & Therapy. (Vol. 2) Peer-ReviewedIntroduction The controlled expression of many genes, including G-protein coupled receptors (GPCRs), is important for delineating gene functions in complex model systems. Binary systems for inducible regulation of...
- 6From: Stem Cell Research & Therapy. (Vol. 2, Issue 33) Peer-ReviewedAlzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and Friedreich's ataxia are the most common human neurodegenerative diseases pathologically characterized by a progressive...
- 7From: Stem Cell Research & Therapy. (Vol. 2, Issue 30) Peer-ReviewedThe MRL (Murphy Roths Large) mouse has provided a unique model of adult mammalian regeneration as multiple tissues show this important phenotype. Furthermore, the healing employs a blastema-like structure similar to...
- 8From: Stem Cell Research & Therapy. (Vol. 2) Peer-ReviewedIntroduction A combination of gene and cell therapies has the potential to significantly enhance the therapeutic value of mesenchymal stem cells (MSCs). The development of efficient gene delivery methods is essential...
- 9From: Stem Cell Research & Therapy. (Vol. 2) Peer-ReviewedIntroduction Multipotent stromal cells (MSCs) are currently in clinical trials for a number of inflammatory diseases. Recent studies have demonstrated the ability of MSCs to attenuate inflammation in rodent models of...
- 10From: Stem Cell Research & Therapy. (Vol. 2) Peer-ReviewedIntroduction Mesenchymal stem cells (MSCs) play a central role in mediating endogenous repair of cell and tissue damage. Biologic aging is a universal process that results in changes at the cellular and molecular...
- 11From: Stem Cell Research & Therapy. (Vol. 2) Peer-ReviewedIntroduction Owing to wide availability, low cost and avoidance of ethical concerns, umbilical cord blood (UCB) provides an attractive source of stem cells for investigational and therapeutic uses. In this study, we...
- 12From: Stem Cell Research & Therapy. (Vol. 2) Peer-ReviewedIntroduction Unrestricted somatic stem cells (USSC) derived from umbilical cord blood are an attractive alternative to human embryonic stem cells (hESC) for cellular therapy. USSC are capable of forming cells...
- 13From: Stem Cell Research & Therapy. (Vol. 2, Issue 40) Peer-ReviewedThere are many similarities between health issues affecting military and civilian patient populations, with the exception of the relatively small but vital segment of active soldiers who experience high-energy blast...
- 14From: Stem Cell Research & Therapy. (Vol. 2) Peer-ReviewedIntroduction The induced pluripotent stem cell (iPSC) technology allows generation of patient-specific pluripotent stem cells, thereby providing a novel cell-therapy platform for severe degenerative diseases. One of...
- 15From: Stem Cell Research & Therapy. (Vol. 2) Peer-ReviewedIntroduction Soluble amyloid precursor protein [alpha] (sAPP[alpha]) is a proteolyte of APP cleavage by [alpha]-secretase. The significance of the cleavage and the physiological role of sAPP[alpha] are unknown. A...
- 16From: Stem Cell Research & Therapy. (Vol. 2, Issue 34) Peer-ReviewedMesenchymal stem (stromal) cells (MSCs) are rare, multipotent progenitor cells that can be isolated and expanded from bone marrow and other tissues. Strikingly, MSCs modulate the functions of immune cells, including T...
- 17From: Stem Cell Research & Therapy. (Vol. 2) Peer-ReviewedIntroduction Stem cell transplantation is a promising therapeutic strategy for the treatment of stroke. Mesenchymal stem cells (MSCs) are a potential cell source for clinical application because they can be easily...
- 18From: Stem Cell Research & Therapy. (Vol. 2) Peer-ReviewedIntroduction Pluripotent, human stem cells hold tremendous promise as a source of progenitor and terminally differentiated cells for application in future regenerative therapies. However, such therapies will be...
- 19From: Stem Cell Research & Therapy. (Vol. 2) Peer-ReviewedBackground The purpose of this study was to characterize the radiobiological properties of stem/progenitor cells derived from apical papilla-derived cells (APDCs) compared to bulk APDCs. Methods APDCs were...
- 20From: Stem Cell Research & Therapy. (Vol. 2) Peer-ReviewedIntroduction Octamer-binding transcription factor 4 (Oct4) is a master regulator of early mammalian development. Its expression begins from the oocyte stage, becomes restricted to the inner cell mass of the...