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- 1From: Acta Neuropathologica Communications. (Vol. 2, Issue 1) Peer-ReviewedBackground The progressive development of Alzheimer's disease (AD) pathology follows a spatiotemporal pattern in the human brain. In a transgenic (Tg) mouse model of AD expressing amyloid precursor protein (APP) with...
- 2From: Acta Neuropathologica Communications. (Vol. 2, Issue 1) Peer-ReviewedAuthor(s): Alexander Schulz1,2 , Ansgar Zoch1 and Helen Morrison1 The hereditary disease Neurofibromatosis type 2 Mutations in the NF2 gene are causative for the autosomal-dominant disease Neurofibromatosis Type 2...
- 3From: Acta Neuropathologica Communications. (Vol. 2, Issue 1) Peer-ReviewedAuthor(s): Cristian A Lasagna-Reeves1,2,4 , Urmi Sengupta1,2 , Diana Castillo-Carranza1,2 , Julia E Gerson1,2 , Marcos Guerrero-Munoz1,2 , Juan C Troncoso3 , George R Jackson1,2 and Rakez Kayed1,2 The...
- 4From: Acta Neuropathologica Communications. (Vol. 2, Issue 1) Peer-ReviewedAuthor(s): Atsushi Kobayashi1 , Yuichi Matsuura2 , Shirou Mohri1 and Tetsuyuki Kitamoto1 Dura mater grafts used to repair the dural defects at neurosurgery can cause fatal disease years to decades later. The tragedy...
- 5From: Acta Neuropathologica Communications. (Vol. 2, Issue 1) Peer-ReviewedAuthor(s): Miguel A Gama Sosa1,4,8 , Rita De Gasperi2,4,8 , Pierce L Janssen5 , Frank J Yuk5 , Pamela C Anazodo2,4 , Paul E Pricop2,4 , Alejandro J Paulino2,4 , Bridget Wicinski5 , Michael C Shaughness9 , Eric...
- 6From: Acta Neuropathologica Communications. (Vol. 2, Issue 1) Peer-ReviewedAuthor(s): Vincent Peter Collins1,5 , Koichi Ichimura1,4 , Ying Di1 , Danita Pearson1 , Ray Chan1 , Lindsay C Thompson2 , Rhian Gabe2 , Michael Brada3 , Sally P Stenning2 and Randomised clinical trials provide a...
- 7From: Acta Neuropathologica Communications. (Vol. 2, Issue 1) Peer-ReviewedAuthor(s): Takashi Ayaki1 , Hidefumi Ito1 , Hiroko Fukushima2 , Takeshi Inoue2 , Takayuki Kondo3,4 , Akito Ikemoto5 , Takeshi Asano4 , Akemi Shodai4 , Takuji Fujita6 , Satoshi Fukui7 , Hiroyuki Morino8 , Satoshi Nakano9...
- 8From: Acta Neuropathologica Communications. (Vol. 2, Issue 1) Peer-Reviewed
WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma
TP53 mutations confer subgroup specific poor survival for children with medulloblastoma. We hypothesized that WNT activation which is associated with improved survival for such children abrogates TP53 related... - 9From: Acta Neuropathologica Communications. (Vol. 2, Issue 1) Peer-ReviewedNemaline myopathy (NM) is a rare congenital myopathy characterised by hypotonia, muscle weakness, and often skeletal muscle deformities with the presence of nemaline bodies (rods) in the muscle biopsy. The nebulin (NEB)...
- 10From: Acta Neuropathologica Communications. (Vol. 2, Issue 1) Peer-ReviewedBackground Parkinson's disease (PD) is the most prevalent neurodegenerative motor disorder. The neuropathology is characterized by intraneuronal protein aggregates of [alpha]-synuclein and progressive degeneration of...
- 11From: Acta Neuropathologica Communications. (Vol. 2, Issue 1) Peer-ReviewedAuthor(s): Henrieta Scholtzova1 , Peter Chianchiano1 , Jason Pan1 , Yanjie Sun1 , Fernando Goéi1 , Pankaj D Mehta3 and Thomas Wisniewski2 Alzheimer's disease (AD) is the most common cause of dementia globally [1]. AD...
- 12From: Acta Neuropathologica Communications. (Vol. 2, Issue 1) Peer-ReviewedAuthor(s): Dana M Niedowicz1 , Valerie L Reeves1,2 , Thomas L Platt2 , Katharina Kohler1 , Tina L Beckett1 , David K Powell4 , Tiffany L Lee1,3 , Travis R Sexton2 , Eun Suk Song2 , Lawrence D Brewer3 , Caitlin S...
- 13From: Acta Neuropathologica Communications. (Vol. 2, Issue 1) Peer-ReviewedAuthor(s): William J Zinnanti5 , Jelena Lazovic6 , Cathy Housman3 , David A Antonetti4 , David M Koeller5 , James R Connor6 and Lawrence Steinman5 Background Ischemic and hemorrhagic strokes have been extensively...
- 14From: Acta Neuropathologica Communications. (Vol. 2, Issue 1) Peer-ReviewedAuthor(s): Giulio Fiaschetti1 , Christina Schroeder3 , Deborah Castelletti1 , Alexandre Arcaro3 , Frank Westermann2 , Martin Baumgartner1 , Tarek Shalaby1 and Michael A Grotzer1 Medulloblastoma (MB) is the most...
- 15From: Acta Neuropathologica Communications. (Vol. 2, Issue 1) Peer-ReviewedAuthor(s): Waney Squier1 and Anna Jansen2,3 The name polymicrogyria (PMG) implies cortical gyri which are too many and too small, but the pathology, imaging and clinical manifestations of PMG are heterogeneous [1]....
- 16From: Acta Neuropathologica Communications. (Vol. 2, Issue 1) Peer-ReviewedIntroduction Several neurodegenerative diseases are classified as proteopathies as they are associated with the aggregation of misfolded proteins. Synucleinopathies are a group of neurodegenerative disorders...
- 17From: Acta Neuropathologica Communications. (Vol. 2, Issue 1) Peer-ReviewedAlzheimer's disease (AD) is the most common neurodegenerative disease and the leading cause of dementia. In addition to grey matter pathology, white matter changes are now recognized as an important pathological feature...
- 18From: Acta Neuropathologica Communications. (Vol. 2, Issue 1) Peer-ReviewedComplex cortical malformations associated with mutations in tubulin genes are commonly referred to as "Tubulinopathies". To further characterize the mutation frequency and phenotypes associated with tubulin mutations,...
- 19From: Acta Neuropathologica Communications. (Vol. 2, Issue 1) Peer-ReviewedIntroduction Recent histopathological studies have shown that neurodegenerative processes in Alzheimer's and Parkinson's Disease develop along neuronal networks and that hallmarks could propagate trans-synaptically...
- 20From: Acta Neuropathologica Communications. (Vol. 2, Issue 1) Peer-ReviewedSynaptic dysfunction and synapse loss are key features of Alzheimer's pathogenesis. Previously, we showed an essential function of APP and APLP2 for synaptic plasticity, learning and memory. Here, we used organotypic...