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- 1From: Nature Structural and Molecular Biology. (Vol. 19, Issue 3) Peer-ReviewedMethylation of histones is central to chromatin regulation, and thus previously unknown mechanisms regulating genome function can be revealed through the discovery of new histone methyl marks. Here we identify Set5 as...
- 2From: Nature Structural and Molecular Biology. (Vol. 19, Issue 3) Peer-ReviewedF-actin serves as a track for myosin's motor functions and activates its ATPase activity by several orders of magnitude, enabling actomyosin to produce effective force against load. Although actin activation is a...
- 3From: Nature Structural and Molecular Biology. (Vol. 19, Issue 3) Peer-ReviewedUBC13 and UbcH5 are E2 ubiquitin-conjugating enzymes important in DNA damage response that are inhibited by the deubiquitinase OTUB1. This inhibition is independent of OTUB1's catalytic activity, but requires OTUB1's...
- 4From: Nature Structural and Molecular Biology. (Vol. 19, Issue 3) Peer-ReviewedDNA double-strand break (DSB) repair interferes with ongoing cellular processes, including replication and transcription. Although the process of replication stalling upon collision of replication forks with damaged DNA...
- 5From: Nature Structural and Molecular Biology. (Vol. 19, Issue 3) Peer-ReviewedWhen the first two animal miRNAs, lin-4 and let-7, were discovered in Caenorhabditis elegans, genetic analyses uncovered a small set of regulated mRNAs that used partial sequence complementarity in their 3' UTRs to...
- 6From: Nature Structural and Molecular Biology. (Vol. 19, Issue 3) Peer-ReviewedUnderstanding and controlling the mechanism by which stem cells balance self-renewal versus differentiation is of great importance for stem cell therapeutics. Klf4 promotes the self-renewal of embryonic stem cells, but...
- 7From: Nature Structural and Molecular Biology. (Vol. 19, Issue 3) Peer-ReviewedNucleotide excision repair (NER) is used by all organisms to eliminate DNA lesions. We determined the structure of the Geobacillus stearothermophilus UvrA-UvrB complex, the damage-sensor in bacterial NER and a new...
- 8From: Nature Structural and Molecular Biology. (Vol. 19, Issue 3) Peer-ReviewedBrad R Rosenberg, Claire E Hamilton, Michael M Mwangi, Scott Dewell & F Nina Papavasiliou Nat. Struct. Mol. Biol. 18, 230-236 (2011); published online 23 January 2011; corrected after print 14 December 2011 In the...
- 9From: Nature Structural and Molecular Biology. (Vol. 19, Issue 3) Peer-ReviewedThe conserved TREX-2 transcription-export complex integrates transcription and processing of many actively transcribed nascent mRNAs with the recruitment of export factors at nuclear pores and also contributes to...
- 10From: Nature Structural and Molecular Biology. (Vol. 19, Issue 3) Peer-ReviewedTelomeres hide (or 'cap') chromosome ends from DNA-damage surveillance mechanisms that arrest the cell cycle and promote repair, but the checkpoint status of telomeres is not well understood. Here we characterize the...
- 11From: Nature Structural and Molecular Biology. (Vol. 19, Issue 3) Peer-ReviewedGareth J Williams, R Scott Williams, Jessica S Williams, Gabriel Moncalian, Andrew S Arvai, Oliver Limbo, Grant Guenther, Soumita SilDas, Michal Hammel, Paul Russell & John A Tainer Nat. Struct. Mol. Biol. 18,...
- 12From: Nature Structural and Molecular Biology. (Vol. 19, Issue 3) Peer-ReviewedWe report a structure of a trimeric glutamate transporter homolog from Pyrococcus horikoshii with two protomers in an inward facing state and the third in an intermediate conformation between the outward and inward...
- 13From: Nature Structural and Molecular Biology. (Vol. 19, Issue 3) Peer-ReviewedAnna Rubio-Cosials, Jasmin F Sidow, Nereida Jimenez-Menendez, Pablo Fernandez-Millan, Julio Montoya, Howard T Jacobs, Miquel Coll, Pau Bernado & Maria Sola Nat. Struct. Mol. Biol. 18, 1281-1289 (2011); published...
- 14From: Nature Structural and Molecular Biology. (Vol. 19, Issue 3) Peer-ReviewedIn hippocampal neurons, the scaffold protein AKAP79 recruits the phosphatase calcineurin to L-type [Ca.sup.2+] channels and couples [Ca.sup.2+] influx to activation of calcineurin and of its substrate, the transcription...
- 15From: Nature Structural and Molecular Biology. (Vol. 19, Issue 3) Peer-ReviewedMicroRNAs (miRNAs) regulate mRNA targets through perfect pairing with their seed region (positions 2-7). Recently, a precise genome-wide map of miRNA interaction sites in mouse brain was generated by high-throughput...
- 16From: Nature Structural and Molecular Biology. (Vol. 19, Issue 3) Peer-ReviewedSilencing mediated by Polycomb repressor complexes (PRCs) in embryonic stem cells (ESCs) can be accompanied by histone marks typical of active genes and RNA polymerase II (RNAPII) presence. A study by Pombo and...
- 17From: Nature Structural and Molecular Biology. (Vol. 19, Issue 3) Peer-ReviewedNeisseria meningitidis, the causative agent of bacterial meningitis, acquires the essential element iron from the host glycoprotein transferrin during infection through a surface transferrin receptor system composed of...
- 18From: Nature Structural and Molecular Biology. (Vol. 19, Issue 3) Peer-Reviewed
Erratum: Crystal structure of a monomeric retroviral protease solved by protein folding game players
Firas Khatib, Frank DiMaio, Foldit Contenders Group, Foldit Void Crushers Group, Seth Cooper, Maciej Kazmierczyk, Miroslaw Gilski, Szymon Krzywda, Helena Zabranska, Iva Pichova, James Thompson, Zoran Popovic, Mariusz... - 19From: Nature Structural and Molecular Biology. (Vol. 19, Issue 3) Peer-ReviewedThe 20S particle, which is composed of the N-ethylmaleimide-sensitive factor (NSF), soluble NSF attachment proteins (SNAPs) and the SNAP receptor (SNARE) complex, has an essential role in intracellular vesicle fusion...
- 20From: Nature Structural and Molecular Biology. (Vol. 19, Issue 3) Peer-ReviewedMarc R Fabian, Maja K Cieplak, Filipp Frank, Masahiro Morita, Jonathan Green, Tharan Srikumar, Bhushan Nagar, Tadashi Yamamoto, Brian Raught, Thomas F Duchaine & Nahum Sonenberg Nat. Struct. Mol. Biol. 18, 1211-1217...