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- 1From: Journal of Biomedical Science. (Vol. 19, Issue 1) Peer-ReviewedBackground MALT1 belongs to a family of paracaspase and modulates NF-κB signaling pathways through its scaffolding function and proteolytic activity. MALT1 cleaves protein substrates after a positively charged...
- 2From: Journal of Biomedical Science. (Vol. 19, Issue 1) Peer-ReviewedBackground Whereas brain death is a vitally important clinical phenomenon, our contemporary understanding on its underlying cellular mechanisms remains elusive. This study evaluated whether the ubiquitin-proteasome...
- 3From: Journal of Biomedical Science. (Vol. 19) Peer-ReviewedBackground Gene therapy and viral therapy are used for cancer therapy for many years, but the results are less than satisfactory. Our aim was to construct a new recombinant adenovirus which is more efficient to kill...
- 4From: Journal of Biomedical Science. (Vol. 19) Peer-ReviewedBackground In an effort to achieve better cancer therapies, we elucidated the combination cancer therapy of STI571 (an inhibitor of Bcr-Abl and clinically used for chronic myelogenous leukemia) and TNF-related...
- 5From: Journal of Biomedical Science. (Vol. 19, Issue 1) Peer-ReviewedBackground Shikonin, a phytochemical purified from Lithospermum erythrorhizon, has been shown to confer diverse pharmacological activities, including accelerating granuloma formation, wound healing, anti-inflammation...
- 6From: Journal of Biomedical Science. (Vol. 19, Issue 1) Peer-ReviewedBackground Intrauterine balloon aortic valvuloplasty (IUBAV) has been used for critical aortic stenosis. However, it is necessary to determine the fetal impairments such as preterm birth after this approach and to...
- 7From: Journal of Biomedical Science. (Vol. 19, Issue 1) Peer-ReviewedBackground Recent data have suggested a relationship between acute arthritic pain and acid sensing ion channel 3 (ASIC3) on primary afferent fibers innervating joints. The purpose of this study was to clarify the...
- 8From: Journal of Biomedical Science. (Vol. 19, Issue 1) Peer-ReviewedBackground The root bark of Paeonia suffruticosa Andrews (PSE), also known as Moutan Cortex, has been widely used in Asia to treat various diseases. The molecular mechanisms by which PSE exerts its anti-oxidant and...
- 9From: Journal of Biomedical Science. (Vol. 19, Issue 1) Peer-ReviewedBackground The mechanisms of the antinociceptive activity of (-) epicatechin (EPI), a compound isolated from the hydroalcoholic fraction of Combreum leprosum Mart & Eicher. Methods were assessed in the model of...
- 10From: Journal of Biomedical Science. (Vol. 19) Peer-ReviewedBackground One of the pathological hallmarks of Alzheimer's disease (AD) is the deposition of the ~4 kDa amyloid [beta] protein (A[beta]) within lesions known as senile plaques. A[beta] is also deposited in the walls...
- 11From: Journal of Biomedical Science. (Vol. 19, Issue 1) Peer-ReviewedBackground Diallyl trisulfide (DATS) is one of the major constituents in garlic oil and has demonstrated various pharmacological activities, including antimicrobial, antihyperlipidemic, antithrombotic, and anticancer...
- 12From: Journal of Biomedical Science. (Vol. 19, Issue 1) Peer-ReviewedBackground The Aim of this study is to study the minimum zinc dependent metalloprotease catalytic folding motif, helix B Met loop-helix C, with proteolytic catalytic activities in metzincin super family. The...
- 13From: Journal of Biomedical Science. (Vol. 19) Peer-ReviewedThrombomodulin (TM) is a cell surface glycoprotein which is widely expressed in a variety of cell types. It is a cofactor for thrombin binding that mediates protein C activation and inhibits thrombin activity. In...
- 14From: Journal of Biomedical Science. (Vol. 19, Issue 1) Peer-ReviewedBackground Lethal toxin (LT) is a major virulence factor of Bacillus anthracis. Sprague Dawley rats manifest pronounced lung edema and shock after LT treatments, resulting in high mortality. The heart failure that is...
- 15From: Journal of Biomedical Science. (Vol. 19, Issue 1) Peer-ReviewedBackground Dysmorphogenesis and multiple organ defects are well known in zebrafish (Danio rerio) embryos with T-box transcription factor 5 (tbx5) deficiencies, mimicking human Holt-Oram syndrome. Methods Using...
- 16From: Journal of Biomedical Science. (Vol. 19, Issue 1) Peer-ReviewedBackground Vaginal epithelial cells have receptors, signal transduction mechanisms, and cytokine secretion capabilities to recruit host defenses against Candida albicans infections. This research evaluates how...
- 17From: Journal of Biomedical Science. (Vol. 19) Peer-ReviewedBackground Naturally occurring pre-S deletion mutants have been identified in hepatitis B carriers and shown to be associated with the development of hepatocellular carcinoma. The phenotypes of these pre-S deletion...
- 18From: Journal of Biomedical Science. (Vol. 19) Peer-ReviewedBackground Most filarial nematodes contain Wolbachia symbionts. The purpose of this study was to examine the effects of doxycycline on gene expression in Wolbachia and adult female Brugia malayi. Methods Brugia...
- 19From: Journal of Biomedical Science. (Vol. 19, Issue 1) Peer-ReviewedBackground Although diabetes mellitus (DM) can be treated with islet transplantation, a scarcity of donors limits the utility of this technique. This study investigated whether human mesenchymal stem cells (MSCs)...
- 20From: Journal of Biomedical Science. (Vol. 19, Issue 1) Peer-ReviewedBackground Iron homeostasis is chiefly regulated by hepcidin whose expression is tightly controlled by inflammation, iron stores, and hypoxia. Hemojuvelin (HJV) is a bone morphogenetic protein co-receptor that has...