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- 1From: Molecular Psychiatry. (Vol. 18, Issue 9) Peer-ReviewedMajor depression, a common mental illness affecting millions of people worldwide, is one of the leading causes of morbidity and has a significant economic cost. Although the mechanisms of action are not well understood,...
- 2From: Molecular Psychiatry. (Vol. 18, Issue 9) Peer-ReviewedBenzodiazepines treat anxiety, but can also produce euphoric effects, contributing to abuse. Using perfusion magnetic resonance imaging, we provide the first direct evidence in humans that alprazolam (Xanax) acutely...
- 3From: Molecular Psychiatry. (Vol. 18, Issue 9) Peer-ReviewedThe 'Vascular Depression' hypothesis posits that cerebrovascular disease may predispose, precipitate or perpetuate some geriatric depressive syndromes. This hypothesis stimulated much research that has improved our...
- 4From: Molecular Psychiatry. (Vol. 18, Issue 9) Peer-ReviewedGlucocorticoids (GCs) secreted after stress reduce adult hippocampal neurogenesis, a process that has been implicated in cognitive aspects of psychopathology, amongst others. Yet, the exact role of the GC receptor (GR),...
- 5From: Molecular Psychiatry. (Vol. 18, Issue 9) Peer-ReviewedThe complex etiology of suicidal behavior has frequently been investigated in relation to monoaminergic neurotransmission, but other neurosystems have shown alterations as well, involving excitatory glutamatergic and...
- 6From: Molecular Psychiatry. (Vol. 18, Issue 9) Peer-ReviewedStudies of the relationship between stress and the liability to depression involve the interposition of multiple factors, and not all findings are intuitive. As an example, contrary to expectation, Kendler et al., (1,2)...
- 7From: Molecular Psychiatry. (Vol. 18, Issue 9) Peer-ReviewedGlucagon-like peptide-1 (GLP-1) is released in response to food intake and acts through both peripheral and central mechanisms to regulate energy homeostasis and feeding behavior. Exendin-4 (Ex-4) is an analog of GLP-1...
- 8From: Molecular Psychiatry. (Vol. 18, Issue 9) Peer-ReviewedA decrease in dopamine D2 receptor (D2R) binding in the striatum is one of the most common findings in disorders that involve a dysregulation of motivation, including obesity, addiction and attention deficit...
- 9From: Molecular Psychiatry. (Vol. 18, Issue 9) Peer-ReviewedThe nonapeptide oxytocin (OT), dubbed by the media as the 'moral' or 'love' molecule, has a variety of pro-social effects across species. A relatively simple explanation for these complex effects is that OT alleviates...
- 10From: Molecular Psychiatry. (Vol. 18, Issue 9) Peer-ReviewedEndogenous glucocorticoids are essential for mobilizing energy resources, restraining inflammatory responses and coordinating behavior to an immune challenge. Impaired glucocorticoid receptor (GR) function has been...
- 11From: Molecular Psychiatry. (Vol. 18, Issue 9) Peer-ReviewedIn an effort to understand how environmental experiences contribute to risk for major depression (MD), we conducted joint autobiographical interviews with 14 pairs of monozygotic twins (mean age 51.2) rigorously...
- 12From: Molecular Psychiatry. (Vol. 18, Issue 9) Peer-ReviewedPTSD: AF150 (slice 96, posterior cingulate); TC: PQ063 (slice 96, posterior cingulate), HC: JC446 (slice 96, posterior cingulate). For more information on this topic, please refer to the article by Neumeister et al., on...
- 13From: Molecular Psychiatry. (Vol. 18, Issue 9) Peer-ReviewedAdenosine-to-inosine (A-to-I) RNA editing is a neurodevelopmentally regulated epigenetic modification shown to modulate complex behavior in animals. Little is known about human A-to-I editing, but it is thought to...
- 14From: Molecular Psychiatry. (Vol. 18, Issue 9) Peer-ReviewedRecent meta-analyses have stimulated an active debate on whether the serotonin transporter gene-linked polymorphic region (5-HTTLPR) is associated with an elevated vulnerability to psychiatric diseases upon exposure to...
- 15From: Molecular Psychiatry. (Vol. 18, Issue 9) Peer-ReviewedEndocannabinoids and their attending cannabinoid type 1 ([CB.sub.1]) receptor have been implicated in animal models of post-traumatic stress disorder (PTSD). However, their specific role has not been studied in people...