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- 1From: Molecular Psychiatry. (Vol. 18, Issue 6) Peer-ReviewedA [Val.sup.66]Met single-nucleotide polymorphism (SNP) in the brain-derived neurotrophic factor (BDNF) gene impairs activity-dependent BDNF release in cultured hippocampal neurons and predicts impaired memory and...
- 2From: Molecular Psychiatry. (Vol. 18, Issue 6) Peer-ReviewedTourette's syndrome (TS) is a developmental disorder that has one of the highest familial recurrence rates among neuropsychiatry diseases with complex inheritance. However, the identification of definitive TS...
- 3From: Molecular Psychiatry. (Vol. 18, Issue 6) Peer-ReviewedMolecular Psychiatry (2013) 18, 738; doi:10.1038/mp.2012.89; published online 5 March 2013 Correction to: Molecular Psychiatry advance online publication, 22 May 2012;doi: 10.1038/mp.2012.67 Following the online...
- 4From: Molecular Psychiatry. (Vol. 18, Issue 6) Peer-ReviewedIn influencing risk for psychiatric and substance use disorders, genes are typically conceptualized as working in silent physiological pathways in the bowels of our biology, far from the influences of human desires. I...
- 5From: Molecular Psychiatry. (Vol. 18, Issue 6) Peer-ReviewedThe serotonergic neurons of the dorsal raphe (DR) nucleus in the CNS are involved in fear, anxiety and depression. Depression and anxiety occur quite frequently in postmenopausal women, but estrogen replacement to...
- 6From: Molecular Psychiatry. (Vol. 18, Issue 6) Peer-ReviewedMolecular Psychiatry (2013) 18, 632-634; doi:10.1038/mp.2013.5 Two outstanding papers appear in this month's issue, with significant clinical implications related to the role of stress mediators in the...
- 7From: Molecular Psychiatry. (Vol. 18, Issue 6) Peer-ReviewedChanges in [serotonin.sub.2C] receptor (5-HTR2c) editing, splicing and density were found in conditions such as depression and suicide, but mechanisms explaining the changes in 5-HTR2c function are unknown. Thus, mice...
- 8From: Molecular Psychiatry. (Vol. 18, Issue 6) Peer-ReviewedThe hypothalamic-pituitary-adrenal (HPA) axis and the inflammatory response system have been suggested as pathophysiological mechanisms implicated in the etiology of major depressive disorder (MDD). Although...
- 9From: Molecular Psychiatry. (Vol. 18, Issue 6) Peer-ReviewedMolecular Psychiatry (2013) 18, 635-636; doi: 10.1038/mp.2012.88; published online 26 June 2012 Advanced paternal age is epidemiologically-linked to an increased risk of several human neuropsychiatric conditions...
- 10From: Molecular Psychiatry. (Vol. 18, Issue 6) Peer-ReviewedMolecular Psychiatry (2013) 18, 636-638; doi:10.1038/mp.2012.74; published online 29 May 2012 Using stringent criteria, we followed-up a genome-wide association study (GWAS) finding (1) to examine the involvement of...
- 11From: Molecular Psychiatry. (Vol. 18, Issue 6) Peer-Reviewed478/410/88 346/456/174 383/441/152 540/371/65 Molecular Psychiatry (2013) 18, 638-639; doi: 10.1038/mp.2012.63; published online 15 May 2012 Schizophrenia is a complex psychiatric disorder with a high...
- 12From: Molecular Psychiatry. (Vol. 18, Issue 6) Peer-ReviewedResiliency to the adverse effects of extraordinary emotional trauma on the brain varies within the human population. Accordingly, some people cope better than others with traumatic stress. Neuropeptide Y (NPY) is a...
- 13From: Molecular Psychiatry. (Vol. 18, Issue 6) Peer-ReviewedBacterial colonisation of the intestine has a major role in the post-natal development and maturation of the immune and endocrine systems. These processes are key factors underpinning central nervous system (CNS)...
- 14From: Molecular Psychiatry. (Vol. 18, Issue 6) Peer-ReviewedDefining the drug-induced neuroadaptations specifically associated with the behavioral manifestation of addiction is a daunting task. To address this issue, we used a behavioral model that differentiates rats...
- 15From: Molecular Psychiatry. (Vol. 18, Issue 6) Peer-ReviewedThe Schizophrenia Psychiatric Genome-Wide Association Study Consortium (PGC) highlighted 81 single-nucleotide polymorphisms (SNPs) with moderate evidence for association to schizophrenia. After follow-up in independent...
- 16From: Molecular Psychiatry. (Vol. 18, Issue 6) Peer-ReviewedUpon binding of Cortisol, the glucocorticoid receptor (GR) regulates the transcription of specific target genes, including those that encode the stress hormones corticotropin-releasing hormone (CRH) and...
- 17From: Molecular Psychiatry. (Vol. 18, Issue 6) Peer-ReviewedMolecular Psychiatry (2013) 18, 631; doi: 10.1038/mp.2013.53 Functional genetic variation in BDNF (brain-derived neurotrophic factor) is posited to impact neural activity in the hippocampus in a manner relevant to...
- 18From: Molecular Psychiatry. (Vol. 18, Issue 6) Peer-ReviewedThe corticotrophin-releasing hormone (CRH) system integrates the stress response and is associated with stress-related psychopathology. Previous reports have identified interactions between childhood trauma and sequence...