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- 1From: Nature Structural and Molecular Biology. (Vol. 18, Issue 5) Peer-ReviewedThe vitamin D receptor (VDR) functions as an obligate heterodimer in complex with the retinoid X receptor (RXR). These nuclear receptors are multidomain proteins, and it is unclear how various domains interact with one...
- 2From: Nature Structural and Molecular Biology. (Vol. 18, Issue 5) Peer-ReviewedERAP1 trims antigen precursors to fit into MHC class I proteins. To fulfill this function, ERAP1 has unique substrate preferences, trimming long peptides but sparing shorter ones. To identify the structural basis for...
- 3From: Nature Structural and Molecular Biology. (Vol. 18, Issue 5) Peer-ReviewedBRAF-to-CRAF signal switching in melanoma is due to the presence of mutant RAS (1), although precisely how this switch occurs has remained unclear until now. The current study by Marquette et al. (2) provides new...
- 4From: Nature Structural and Molecular Biology. (Vol. 18, Issue 5) Peer-ReviewedAmong antibody classes, IgE has a uniquely slow dissociation rate from, and high affinity for, its cell surface receptor Fc[epsilon]RI. We show the structural basis for these key determinants of the ability of IgE to...
- 5From: Nature Structural and Molecular Biology. (Vol. 18, Issue 5) Peer-ReviewedThe CRISPR (clustered regularly interspaced short palindromic repeats) immune system in prokaryotes uses small guide RNAs to neutralize invading viruses and plasmids. In Escherichia coli, immunity depends on a...
- 6From: Nature Structural and Molecular Biology. (Vol. 18, Issue 5) Peer-ReviewedDuring the priming step that leaves synaptic vesicles ready for neurotransmitter release, the SNARE syntaxin-1 transitions from a closed conformation that binds Munc18-1 tightly to an open conformation within the highly...
- 7From: Nature Structural and Molecular Biology. (Vol. 18, Issue 5) Peer-ReviewedProduction of functional mRNAs in the mitochondria of trypanosomes involves several steps after transcription of the kinetoplastid DNA. The initial polycistronic precursor mRNAs are cleaved to yield pre-mRNAs and rRNAs....
- 8From: Nature Structural and Molecular Biology. (Vol. 18, Issue 5) Peer-ReviewedIn Escherichia coli, the pole-to-pole oscillation of the Min proteins directs septum formation to midcell, which is required for symmetric cell division. In vitro, protein waves emerge from the self-organization of...
- 9From: Nature Structural and Molecular Biology. (Vol. 18, Issue 5) Peer-ReviewedMelanocytes use BRAF to activate the MAP kinase (MAPK) pathway because CRAF is inhibited by the cyclic AMP (cAMP) pathway in these cells. By contrast, melanomas harboring Ras mutations use CRAF to activate the MAPK...
- 10From: Nature Structural and Molecular Biology. (Vol. 18, Issue 5) Peer-ReviewedHere we describe self-splicing proteins, called inteins, that function as redox-responsive switches in bacteria. Redox regulation was achieved by engineering a disulfide bond between the intein's catalytic cysteine and...
- 11From: Nature Structural and Molecular Biology. (Vol. 18, Issue 5) Peer-ReviewedThe ubiquitous SecY-Sec61 complex translocates nascent secretory proteins across cellular membranes and integrates membrane proteins into lipid bilayers. Several structures of mostly detergent-solubilized Sec complexes...
- 12From: Nature Structural and Molecular Biology. (Vol. 18, Issue 5) Peer-ReviewedDNA viruses such as bacteriophages and herpesviruses deliver their genome into and out of the capsid through large proteinaceous assemblies, known as portal proteins. Here, we report two snapshots of the dodecameric...
- 13From: Nature Structural and Molecular Biology. (Vol. 18, Issue 5) Peer-ReviewedOne of the most notable discoveries in the ubiquitin system during the past decade is the extensive use of diverse chain linkages to control signaling networks. Although the utility of Lys48- and Lys63-linked chains in...
- 14From: Nature Structural and Molecular Biology. (Vol. 18, Issue 5) Peer-ReviewedIt is not currently known in what state (folded, unfolded or alternatively folded) client proteins interact with the chaperone Hsp90. We show that one client, the p53 DNA-binding domain, undergoes a structural change in...
- 15From: Nature Structural and Molecular Biology. (Vol. 18, Issue 5) Peer-ReviewedType IIa receptor protein tyrosine phosphatases (RPTPs), such as RPTP[sigma], LAR and RPTP[delta], are cell-surface receptors with important roles in neuronal development, function and repair. Their ecto-domains...
- 16From: Nature Structural and Molecular Biology. (Vol. 18, Issue 5) Peer-ReviewedActivation of many multidomain signaling proteins requires rearrangement of autoinhibitory interdomain interactions that occlude activator binding sites. In one model for activation, the major inactive conformation...
- 17From: Nature Structural and Molecular Biology. (Vol. 18, Issue 5) Peer-ReviewedThe enzyme-catalyzed addition of a methyl group to the side chain of an amino acid residue is a well-known posttranslational modification, of which the most prominent example is the methylation of lysine and arginine...
- 18From: Nature Structural and Molecular Biology. (Vol. 18, Issue 5) Peer-ReviewedDedicated chaperones facilitate the assembly of the eukaryotic proteasome, but how they function remains largely unknown. Here we show that a yeast 20S proteasome assembly factor, Pba1-Pba2, requires a previously...
- 19From: Nature Structural and Molecular Biology. (Vol. 18, Issue 5) Peer-ReviewedNuclear hormone receptors (NHRs) control numerous physiological processes through the regulation of gene expression. The present study provides a structural basis for understanding the role of DNA in the spatial...
- 20From: Nature Structural and Molecular Biology. (Vol. 18, Issue 5) Peer-ReviewedIt is possible to travel back in time at the molecular level by reconstructing proteins from extinct organisms. Here we report the reconstruction, based on sequence predicted by phylogenetic analysis, of seven...