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- 1From: Nature Medicine. (Vol. 18, Issue 10) Peer-ReviewedA limitation of photodynamic therapy (PDT) is the depth of penetration of visible light needed for activation of the photosensitizers, restricting treatment to tumors on or just under the skin's surface or those lining...
- 2From: Nature Medicine. (Vol. 18, Issue 10) Peer-ReviewedSpinal and bulbar muscular atrophy (SBMA) is a motor neuron disease caused by the expansion of the CAG triplet repeat within the androgen receptor (AR) gene. Here, we demonstrated that pathogenic AR upregulates the gene...
- 3From: Nature Medicine. (Vol. 18, Issue 10) Peer-ReviewedDeficiency of the procoagulant cofactor factor VIII (FVIII) in hemophilia A is routinely treated by protein replacement therapy with plasma-derived or recombinant FVIII. Now, a humanized bispecific antibody has been...
- 4From: Nature Medicine. (Vol. 18, Issue 10) Peer-ReviewedT cells specific for commensals expand and differentiate into memory cells as a result of a parasitic infection in the gastrointestinal tract, according to a new study (Science doi:10.1126/ science. 1220961). Immune...
- 5From: Nature Medicine. (Vol. 18, Issue 10) Peer-ReviewedIn the September 2012 issue, the article entitled "Strapped for funding, medical researchers pitch to the crowd" (Not. Med. 18, 1307, 2012) incorrectly listed Stephen Glatt's professional credentials. He's a...
- 6From: Nature Medicine. (Vol. 18, Issue 10) Peer-ReviewedIn 1950, medical students in the UK were allocated patients for whom we had a special, personal responsibility and acted as advocate. I presented the case of a patient about my age dying of kidney failure. The senior...
- 7From: Nature Medicine. (Vol. 18, Issue 10) Peer-ReviewedConventional photodynamic therapy (PDT) is limited by the penetration depth of visible light needed for its activation. Here we used mesoporous-silica-coated upconversion fluorescent nanoparticles (UCNs) as a...
- 8From: Nature Medicine. (Vol. 18, Issue 10) Peer-ReviewedEradication: Ridding the World of Diseases Forever? Nancy Leys Stepan Cornell University Press, 2011 272 pp., hardcover, $35.00 ISBN: 0801450586 The public health community will face moments of high drama...
- 9From: Nature Medicine. (Vol. 18, Issue 10) Peer-ReviewedInfluenza viruses can cause a broad spectrum of disease severity, including devastating cases in some people. Several factors influence the epidemiological success of the virus; the mechanisms of transmission and the...
- 10From: Nature Medicine. (Vol. 18, Issue 10) Peer-ReviewedSeveral events that contribute to cellular dysfunction are involved in Alzheimer's disease pathology, raising the issue of how amyloid [beta] (A([beta]) peptides can mediate such wide-ranging effects. Now, a recent...
- 11From: Nature Medicine. (Vol. 18, Issue 10) Peer-ReviewedThere is a pressing need to identify prognostic markers of metastatic disease and targets for treatment. Combining high-throughput RNA sequencing, functional characterization, mechanistic studies and clinical...
- 12From: Nature Medicine. (Vol. 18, Issue 10) Peer-ReviewedTwo recent studies identify new gene fusions in solid tumors in humans and provide clues into their role in tumorigenesis (Nature 488, 660-664; Science 337, 1231-1235). Somasekar Seshagiri et al. identified recurrent...
- 13From: Nature Medicine. (Vol. 18, Issue 10) Peer-ReviewedImmune tolerance is instituted early in life, during which time regulatory T ([T.sub.reg]) cells have an important role. Recurrent infections with respiratory syncytial virus (RSV) in early life increase the risk for...
- 14From: Nature Medicine. (Vol. 18, Issue 10) Peer-ReviewedA new study in mice shows that sarcolipin, a small, regulatory protein of the intracellular calcium pump (SERCA) in skeletal muscle, is part of a nonshivering thermogenic mechanism for regulating both core body...
- 15From: Nature Medicine. (Vol. 18, Issue 10) Peer-ReviewedThis year, around 240,000 men in the US alone will be diagnosed with prostate cancer, and most of them will choose to either surgically remove all or part of the prostate gland or undergo radiation treatment. These...
- 16From: Nature Medicine. (Vol. 18, Issue 10) Peer-ReviewedWho is not fascinated by the myriad biological movements that define life? From cell migration, cell division and a network of translocation activities within cells to highly specialized muscle contraction, molecular...
- 17From: Nature Medicine. (Vol. 18, Issue 10) Peer-ReviewedIt is the intrinsic morphology of neurons--not chemical signaling, as previously debated--that largely determines the synapses they form. So says a report published 17 September in the early online edition of...
- 18From: Nature Medicine. (Vol. 18, Issue 10) Peer-ReviewedReactivation of 'metastasis suppressor' genes holds great promise for the treatment of incurable malignancies. To date, only a few of these genes have been identified. A new study shows that breast cancer metastasis can...
- 19From: Nature Medicine. (Vol. 18, Issue 10) Peer-ReviewedA fundamental feature of spermatogenesis in each human male is the continual production of about 1,000 spermatozoa per second from puberty to old age. Contraception of this level of fecundity presents problems different...
- 20From: Nature Medicine. (Vol. 18, Issue 10) Peer-ReviewedMen in the US with advanced prostate cancer now have another treatment option, thanks to the FDA's 31 August approval of a new pill that blocks androgen signaling. In a phase 3 trial involving around 1,200 men with...