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- Search Terms:ISSN: 10788956AndISSN: 1546170XAndVolume Number: 17AndIssue Number: 9AndStart Page: 1136AndDate: 2011 Revise Search
- 1From: Nature Medicine. (Vol. 17, Issue 9) Peer-ReviewedIn an agency-wide e-mail message on 13 I July, US Food and Drug Administration Commissioner Margaret Hamburg unveiled a massive reorganization of the regulatory watchdog's 41-year-old management structure. "The most...
- 2From: Nature Medicine. (Vol. 17, Issue 9) Peer-ReviewedAlthough the role of miR-200s in regulating E-cadherin expression and epithelial-to-mesenchymal transition is well established, their influence on metastatic colonization remains controversial. Here we have used...
- 3From: Nature Medicine. (Vol. 17, Issue 9) Peer-ReviewedLast month, a team of around a dozen doctors and nurses in Connecticut performed a 12-hour operation to insert a cigar-shaped plastic tube, seeded with bone marrow cells, around the heart of a toddler born with only a...
- 4From: Nature Medicine. (Vol. 17, Issue 9) Peer-ReviewedAround one in five US veterans suffering from post-traumatic stress disorder is prescribed an antipsychotic medicine, even though these drugs are not approved for this use. And, according to a 247-veteran, six-month...
- 5From: Nature Medicine. (Vol. 17, Issue 9) Peer-ReviewedThe last decade has seen an explosion in global health spending. Bold measures from nonprofits and government have led to a record number of medications distributed to treat a number of global killers. The World Health...
- 6From: Nature Medicine. (Vol. 17, Issue 9) Peer-ReviewedPrevious studies have proposed roles for hypothalamic reactive oxygen species (ROS) in the modulation of circuit activity of the melanocortin system (1,2). Here we show that suppression of ROS diminishes...
- 7From: Nature Medicine. (Vol. 17, Issue 9) Peer-ReviewedPeroxisome proliferator-activated receptors (PPARs) are important transcriptional regulators of genes involved in energy metabolism. Hydrolysis of cardiac lipid droplets by adipose triglyceride lipase (ATGL) is now...
- 8From: Nature Medicine. (Vol. 17, Issue 9) Peer-ReviewedNew regulations are needed to oversee how animal-human hybrids are used in research, according to the UK Academy of Medical Sciences. In a report released on 21 July, a working group led by geneticist Martin Bobrow of...
- 9From: Nature Medicine. (Vol. 17, Issue 9) Peer-ReviewedOverdiagnosed: Making People Sick in the Pursuit of Health H. Gilbert Welch, Lisa Schwartz and Steve Woloshin Beacon Press, 2011 248 pp., hardcover, $24.95 ISBN:0807022004 A friend recently developed a...
- 10From: Nature Medicine. (Vol. 17, Issue 9) Peer-ReviewedFrance, still reeling from the Mediator scandal in which the diabetes drug (also known by its generic name, benfluorex) remained on the market until November 2009 despite earlier indications that it carried a risk of...
- 11From: Nature Medicine. (Vol. 17, Issue 9) Peer-ReviewedTo the Editor: We read with great interest the paper published in Nature Medicine by Bouman et al. (1) showing that a common paraoxonase-1 (PON1) polymorphism (rs662, also known as Q192R) is a major determinant of...
- 12From: Nature Medicine. (Vol. 17, Issue 9) Peer-ReviewedAs big pharmaceutical firms whittle down their in-house research operations, drugmakers are increasingly relying on for-hire service companies to perform the heavy lifting of drug development. In fact, last year about...
- 13From: Nature Medicine. (Vol. 17, Issue 9) Peer-ReviewedSales of Sanofi's and Bristol-Myers Squibb's blockbuster drug Plavix (clopidogrel) rose 15% in the second quarter of the year, but added competition could soon take a chunk of the $9-billion-a-year medicine's market...
- 14From: Nature Medicine. (Vol. 17, Issue 9) Peer-ReviewedShokrollah Elahi, Warren L Dinges, Nicholas Lejarcegui, Kerry J Laing, Ann C Collier, David M Koelle, M Juliana McElrath & Helen Horton Nat. Med. 17, 989-995 (2011); published online 17 July 2011; corrected after...
- 15From: Nature Medicine. (Vol. 17, Issue 9) Peer-ReviewedA connection between diet, obesity and diabetes exists in multiple species and is the basis of an escalating human health problem. The factors responsible provoke both insulin resistance and pancreatic beta cell...
- 16From: Nature Medicine. (Vol. 17, Issue 9) Peer-ReviewedAlthough many of the world's best known drugmakers hail from Europe, historically the continent's academic institutions haven't been as adept as their US counterparts at spinning off companies. So, in 2008, the European...
- 17From: Nature Medicine. (Vol. 17, Issue 9) Peer-ReviewedThe cancer stem cell (CSC) concept has provocative implications for our understanding of cancer biology and therapy. Its clinical relevance now receives a major boost from the finding that a stem cell-like or...
- 18From: Nature Medicine. (Vol. 17, Issue 9) Peer-ReviewedIn August, after a tense run-up to the default deadline, US lawmakers passed the Budget Control Act. The legislation that increased the debt ceiling contains $917 billion in cuts through 2021, which will probably affect...
- 19From: Nature Medicine. (Vol. 17, Issue 9) Peer-ReviewedThere has long been a recognized association between immunodeficiency and autoimmunity, with a large number of primary immunodeficiency disorders (PIDs) such as X-linked agammaglobulinemia, Wiscott-Aldrich syndrome and...
- 20From: Nature Medicine. (Vol. 17, Issue 9) Peer-ReviewedAn antivenom that neutralizes the fatal nerve-poisoning effects of scorpion stings won US regulatory approval last month on the back of a placebo-controlled trial of just 15 subjects. Leslie Boyer, from the University...