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- 1From: Nature Medicine. (Vol. 17, Issue 8) Peer-ReviewedProtracted negotiations over a wide-ranging free trade agreement between India and the EU have stalled, in part over disagreements surrounding intellectual property rights in areas such as pharmaceuticals. But last...
- 2From: Nature Medicine. (Vol. 17, Issue 8) Peer-ReviewedRecently, a number of miRNAs, including miR-155, have been identified that are differentially regulated in the autoimmune disease arthritis, but the functional pathways through which these molecules might mediate...
- 3From: Nature Medicine. (Vol. 17, Issue 8) Peer-ReviewedA major initiative aimed at tracking down the causes of mysterious illnesses seems to be a victim of its own success. Less than five months after the US National Institutes of Health's Undiagnosed Diseases Program...
- 4From: Nature Medicine. (Vol. 17, Issue 8) Peer-ReviewedSpecific human leukocyte antigens (HLAs), notably HLA-B*27 and HLA-B*57 allele groups, have long been associated with control of HIV-1. Although the majority of HIV-specific [CD8.sup.+] T cells lose proliferative...
- 5From: Nature Medicine. (Vol. 17, Issue 8) Peer-ReviewedNovartis' multiple sclerosis pill Gilenya (fingolimod) got a boost in June when it emerged that the German company Merck KGaA would no longer seek global approval of its rival drug Movectro (cladribine). After US and...
- 6From: Nature Medicine. (Vol. 17, Issue 8) Peer-ReviewedSpontaneous calcium release from intracellular stores can trigger irregular heart beats and sudden death. A new study shows that the heart failure drug carvedilol prevents irregular heart beats by a unique action on...
- 7From: Nature Medicine. (Vol. 17, Issue 8) Peer-ReviewedSince the onset of genomic sequencing, there has been great interest in identifying genetic markers to predict an individual's disease susceptibility. Although the greatest success in identifying such genetic...
- 8From: Nature Medicine. (Vol. 17, Issue 8) Peer-ReviewedAluminum-based adjuvants (aluminum salts or alum) are widely used in human vaccination, although their mechanisms of action are poorly understood. Here we report that, in mice, alum causes cell death and the subsequent...
- 9From: Nature Medicine. (Vol. 17, Issue 8) Peer-ReviewedLi, H. et al. Nature 475, 217-221. By using a targeted zinc finger nuclease approach delivered to the liver with a hepatotropic adeno-associated virus vector, the authors correct a mutant F9 gene in a mouse model of...
- 10From: Nature Medicine. (Vol. 17, Issue 8) Peer-ReviewedTo the Editor: In Nature Medicine's May editorial, "March on, not in" (Nat. Med. 17, 515, 2011), the journal asserts that ending patent exclusivity for Fabrazyme and introducing generic competition in the US "could...
- 11From: Nature Medicine. (Vol. 17, Issue 8) Peer-ReviewedTo rescue an abnormally beating heart, a defibrillator must deliver a whopping 1,000 volts to reset the electric charge in every cell in the organ and allow the heart to resume its rhythm. Such sizeable jolts cause pain...
- 12From: Nature Medicine. (Vol. 17, Issue 8) Peer-ReviewedCertain human leukocyte antigen (HLA) alleles are associated with vigorous human immunodeficiency virus (HlV)-specific [CD8.sup.+] T cell responses and good clinical outcomes. A new study suggests that [CD8.sup.+] T...
- 13From: Nature Medicine. (Vol. 17, Issue 8) Peer-ReviewedUnder state law in the US, drug companies must inform consumers about new information on potential side effects. But federal regulations require generic manufacturers to carry the exact same label details as their...
- 14From: Nature Medicine. (Vol. 17, Issue 8) Peer-ReviewedProgress in understanding, diagnosis, and treatment of coronary artery disease (CAD) has been hindered by our inability to observe cells and extracellular components associated with human coronary atherosclerosis in...
- 15From: Nature Medicine. (Vol. 17, Issue 8) Peer-ReviewedOpen Heart: The Radical Surgeons Who Revolutionized Medicine David Cooper Kaplan Publishing, 2010 448 pp., hardcover, $26.99 ISBN:1607144905 The golden age of innovation in cardiac surgery was marked by...
- 16From: Nature Medicine. (Vol. 17, Issue 8) Peer-ReviewedIn 2008, Avastin (Genentech) was conditionally approved for the treatment ofmetastatic breast cancer through the US Food and Drug Administration's (FDA) accelerated approval process. Approval was based on the results of...
- 17From: Nature Medicine. (Vol. 17, Issue 8) Peer-ReviewedWith painkiller addiction on the rise, drugmakers have come up with clever ways to discourage such behavior. As recently as 20 June, the US Food and Drug Administration (FDA) approved a new abuse-deterrent formulation...
- 18From: Nature Medicine. (Vol. 17, Issue 8) Peer-ReviewedSpider bites often get blamed as the cause of many skin wounds. But according to a report out last month in The Lancet (doi:10.1016/ S0140-6736(10)62230-1), physicians tend to mistakenly ascribe necrotic skin lesions to...
- 19From: Nature Medicine. (Vol. 17, Issue 8) Peer-ReviewedFollicular helper ([T.sub.FH]) cells provide crucial signals to germinal center B cells undergoing somatic hypermutation and selection that results in affinity maturation. Tight control of [T.sub.FH] numbers maintains...
- 20From: Nature Medicine. (Vol. 17, Issue 8) Peer-ReviewedThe ability to turn on expression of a therapeutic protein in vivo simply by shining a light sounds a bit far-fetched, but a recent report from Haifeng Ye et al. shows how this might be achieved (Science 332,...