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- 1From: Gene Therapy. (Vol. 17, Issue 10) Peer-ReviewedLidamycin (LDM) is a new member of enediyne antitumor antibiotics family that can be separated and reconstituted. It consists of a labile active enediyne chromophore (AE) and a noncovalently bound apoprotein (LDP). LDM...
- 2From: Gene Therapy. (Vol. 17, Issue 10) Peer-ReviewedChimeric antigen receptors (CARs, immunoreceptors) are frequently used to redirect T cells with pre-defined specificity, in particular towards tumour cells for use in adoptive immunotherapy of malignant diseases....
- 3From: Gene Therapy. (Vol. 17, Issue 10) Peer-ReviewedNucleic acid-based therapies hold great promise for treatment of skin disorders if delivery challenges can be overcome. To investigate one mechanism of nucleic acid delivery to keratinocytes, a fixed mass of expression...
- 4From: Gene Therapy. (Vol. 17, Issue 10) Peer-ReviewedOncolytic herpes simplex virus (oHSV) vectors have shown promise in the treatment of patients with recurrent brain tumors although few complete responses have accrued. Impediments to effective therapy include limited...
- 5From: Gene Therapy. (Vol. 17, Issue 10) Peer-ReviewedBrain-derived neurotrophic factor (BDNF) is the main candidate for neuroprotective therapeutic strategies for Huntington's disease. However, the administration system and the control over the dosage are still important...
- 6From: Gene Therapy. (Vol. 17, Issue 10) Peer-ReviewedGamma-retroviruses are commonly used to deliver genes to cells. Previously, we demonstrated that the synthetic anti-glucocorticoid and anti-progestin agent, mifepristone, increased gamma-retroviral infection efficiency...
- 7From: Gene Therapy. (Vol. 17, Issue 10) Peer-ReviewedChronic granulomatous disease is a primary immunodeficiency, comprising five molecular defects, characterized by an impaired respiratory burst activity of myeloid cells. We are currently developing a gene therapy vector...
- 8From: Gene Therapy. (Vol. 17, Issue 10) Peer-ReviewedDifferent members of the galectin family may have inhibitory or stimulatory roles in controlling immune responses and regulating inflammatory reactions in autoimmune diseases such as rheumatoid arthritis (RA). A...
- 9From: Gene Therapy. (Vol. 17, Issue 10) Peer-ReviewedEpstein-Barr virus (EBV) evolved an episomal system for maintaining life-long, latent infection of human B lymphocytes. Circular episomes engineered from EBV components required for this latent form of infection have...
- 10From: Gene Therapy. (Vol. 17, Issue 10) Peer-ReviewedChimeric antigen receptors (CARs) are major histocompatibility complex (MHC)-independent one-polypeptide chain receptor molecules that, when expressed in T cells, can redirect specificity towards tumor or viral antigens...
- 11From: Gene Therapy. (Vol. 17, Issue 10) Peer-ReviewedOne of the major hurdles for the development of gene therapy for Fanconi anemia (FA) is the increased sensitivity of FA stem cells to free radical-induced DNA damage during ex vivo culture and manipulation. To minimize...
- 12From: Gene Therapy. (Vol. 17, Issue 10) Peer-ReviewedBoth atherosclerosis and arterial interventions induce oxidative stress mediated in part by nicotinamide adenine dinucleotide phosphate (NADPH) oxidases that have a pivotal role in the development of neointimal...
- 13From: Gene Therapy. (Vol. 17, Issue 10) Peer-Reviewed
Cell-based osteoprotegerin therapy for debris-induced aseptic prosthetic loosening on a murine model
Exogenous osteoprotegerin (OPG) gene modification appears a therapeutic strategy for osteolytic aseptic loosening. The feasibility and efficacy of a cell-based OPG gene delivery approach were investigated using a murine... - 14From: Gene Therapy. (Vol. 17, Issue 10) Peer-ReviewedBone morphogenetic proteins (BMPs), members of the transforming growth factor-[beta] subfamily, function as instructive signals for neuronal lineage commitment and promote neuronal differentiation. However, the...