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- 1From: Nature Medicine. (Vol. 17, Issue 1) Peer-ReviewedAuthor(s): Louise Hecker 1 , David R Crowe 2 , Victor J Thannickal 1 Author Affiliations: (1) Division of Pulmonary, Department of Medicine, Allergy and Critical Care Medicine, University of Alabama at Birmingham,...
- 2From: Nature Medicine. (Vol. 17, Issue 1) Peer-ReviewedAuthor(s): Jean-Claude Pache 1 2 , Stephanie Carnesecchi 1 3 , Christine Deffert 1 2 3 , Yves Donati 1 3 , François R Herrmann 4 , Constance Barazzone-Argiroffo 1 3 , Karl-Heinz Krause 1 2 Author Affiliations: (1)...
- 3From: Nature Medicine. (Vol. 17, Issue 1) Peer-ReviewedWhen Phil Willis, a former school headmaster turned politician, landed a seat on the UK government's Science and Technology Committee in 2005, he found a way to make his mark as a nonscientist by obsessively asking for...
- 4From: Nature Medicine. (Vol. 17, Issue 1) Peer-ReviewedThe architect of California's $3 billion stem cell agency is set to keep his job for a little longer. Bob Klein--the man who co-wrote the ballot initiative that created the California Institute for Regenerative Medicine...
- 5From: Nature Medicine. (Vol. 17, Issue 1) Peer-ReviewedThe main manifestations of nephrotic syndrome include proteinuria, hypoalbuminemia, edema, hyperlipidemia and lipiduria. Common causes of nephrotic syndrome are diabetic nephropathy, minimal change disease (MCD), focal...
- 6From: Nature Medicine. (Vol. 17, Issue 1) Peer-ReviewedMutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) hamper its function, causing cystic fibrosis that severely damages the lung and other organs. A phase 2 study in 40 people...
- 7From: Nature Medicine. (Vol. 17, Issue 1) Peer-ReviewedA new signaling pathway involved in the initiation of labor has now been identified, according to a recent study (Proc. Natl. Acad. Sci. USA 107, 20828-20833, 2010). Uterine contractions are prevented through most of...
- 8From: Nature Medicine. (Vol. 17, Issue 1) Peer-ReviewedGiven the complexity of modern medicine, it's crucial for all people to be biologically literate so that they can make intelligent decisions about themselves and their families as consumers and patients. Individuals who...
- 9From: Nature Medicine. (Vol. 17, Issue 1) Peer-Reviewed
Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin
The adipocyte-derived secretory factor adiponectin promotes insulin sensitivity, decreases inflammation and promotes cell survival. No unifying mechanism has yet explained how adiponectin can exert such a variety of... - 10From: Nature Medicine. (Vol. 17, Issue 1) Peer-ReviewedAdenosine therapy for sickle cell disease has been proposed to improve blood flow, mediate cytoprotection and inhibit natural killer cell activity. Complicating this approach, adenosine signaling also induces hemoglobin...
- 11From: Nature Medicine. (Vol. 17, Issue 1) Peer-ReviewedAs Araldi et al. (1) mention in their correspondence, our previous article describes that mice heterozygous for knockout of the gene encoding hypoxia-inducible factor-2[alpha] ([Epas1.sup.+/-] mice) show mild and...
- 12From: Nature Medicine. (Vol. 17, Issue 1) Peer-ReviewedThe number of people concurrently taking multiple prescription drugs is on the rise. According to numbers released last fall by the US Centers for Disease Control and Prevention, one in ten Americans is now on five or...
- 13From: Nature Medicine. (Vol. 17, Issue 1) Peer-ReviewedMyocardial infarction is a leading cause of mortality worldwide. Here we report that modulation of microRNA-499 (miR-499) levels affects apoptosis and the severity of myocardial infarction and cardiac dysfunction...
- 14From: Nature Medicine. (Vol. 17, Issue 1) Peer-ReviewedSpence, J.R et al. Naturedoi:10.1038/ nature09691 (12 December 2010). Differentiation of human pluripotent stem cells into three-dimensional intestinal tissue recapitulates features of the fetal organ, providing a...
- 15From: Nature Medicine. (Vol. 17, Issue 1) Peer-ReviewedAdenovirus type 37 (Ad37) is a leading cause of epidemic keratoconjunctivitis (EKC) (1,2), a severe and highly contagious ocular disease. Whereas most other adenoviruses infect cells by engaging CD46 or the coxsackie...
- 16From: Nature Medicine. (Vol. 17, Issue 1) Peer-ReviewedLate last year, the US Institute of Medicine released a report stating that research claiming any benefits from vitamin D beyond building strong bones is "inconsistent and inconclusive." Although inert vitamin D...
- 17From: Nature Medicine. (Vol. 17, Issue 1) Peer-ReviewedNov 21 Two independent studies of glioblastoma cells found that tumors can create their own blood supply by generating blood vessel cells. The findings hint at why drugs such as bevacizumab (Avastin) that aim to halt...
- 18From: Nature Medicine. (Vol. 17, Issue 1) Peer-ReviewedWhereas antiretroviral therapy of HIV infection has enormously increased the life expectancy of infected individuals, efforts to prevent HIV have lagged behind--despite the recognized importance of prophylaxis for this...
- 19From: Nature Medicine. (Vol. 17, Issue 1) Peer-ReviewedMEXICO CITY--For decades, Mexican biomedical scientists have focused on basic research, looking with suspicion on those few colleagues who spoke of applying discoveries in the clinic or generating profits. However, this...
- 20From: Nature Medicine. (Vol. 17, Issue 1) Peer-ReviewedPharmaceutical companies have sponsored research at academic centers for decades. But in the past few years, these collaborative agreements have escalated from small one-off contracts with individual labs to broad,...