Showing Results for
- Academic Journals (24)
Search Results
- 24
Academic Journals
- 24
- Search Terms:
- 1From: Nature Structural and Molecular Biology. (Vol. 16, Issue 7) Peer-ReviewedNonsense-mediated decay (NMD) is an RNA decay pathway that downregulates aberrant mRNAs and a subset of normal mRNAs. The regulation of NMD is poorly understood. Here we identify a regulatory mechanism acting on two...
- 2From: Nature Structural and Molecular Biology. (Vol. 16, Issue 7) Peer-ReviewedBrr2 is a DExD/H-box helicase responsible for U4/U6 unwinding during spliceosomal activation. Brr2 contains two helicase-like domains, each of which is followed by a Sec63 domain with unknown function. We determined the...
- 3From: Nature Structural and Molecular Biology. (Vol. 16, Issue 7) Peer-ReviewedDosage compensation in mice and humans involves the inactivation of one X chromosome in females during early differentiation to achieve similar X-associated gene expression in both sexes. Recent data have suggested a...
- 4From: Nature Structural and Molecular Biology. (Vol. 16, Issue 7) Peer-ReviewedIt has proven difficult to predict the structure of a protein on the basis of its amino acid sequence. A new approach described in this issue of Nature Structural & Molecular Biology has revealed important new details...
- 5From: Nature Structural and Molecular Biology. (Vol. 16, Issue 7) Peer-ReviewedHow many times have you heard complaints from colleagues or meeting organizers about researchers who, in trying to obtain or renew visas, have dealt with exceedingly long delays, in some cases as long as several months?...
- 6From: Nature Structural and Molecular Biology. (Vol. 16, Issue 7) Peer-ReviewedHedgehog (Hh) signaling is crucial for many aspects of embryonic development, whereas dysregulation of this pathway is associated with several types of cancer. Hedgehog-interacting protein (Hhip) is a surface receptor...
- 7From: Nature Structural and Molecular Biology. (Vol. 16, Issue 7) Peer-ReviewedVariable lymphocyte receptors (VLRs) are leucine-rich repeat proteins that mediate adaptive immunity in jawless vertebrates. VLRs are fundamentally different from the antibodies of jawed vertebrates, which consist of...
- 8From: Nature Structural and Molecular Biology. (Vol. 16, Issue 7) Peer-ReviewedHedgehog (Hh) morphogens have fundamental roles in development, whereas dysregulation of Hh signaling leads to disease. Multiple cell-surface receptors are responsible for transducing and/or regulating Hh signals. Among...
- 9From: Nature Structural and Molecular Biology. (Vol. 16, Issue 7) Peer-ReviewedInsulators are chromatin boundary elements that help to regulate gene activity by ensuring appropriate interactions between cis-regulatory elements. A number of well-defined insulators present in the Drosophila...
- 10From: Nature Structural and Molecular Biology. (Vol. 16, Issue 7) Peer-ReviewedEndosomal sorting complexes required for transport-III (ESCRT-III) subunits cycle between two states: soluble monomers and higher-order assemblies that bind and remodel membranes during endosomal vesicle formation,...
- 11From: Nature Structural and Molecular Biology. (Vol. 16, Issue 7) Peer-ReviewedBox H/ACA small nucleolar and Cajal body ribonucleoprotein particles comprise the most complex pseudouridine synthases and are essential for ribosome and spliceosome maturation. The multistep and multicomponent-mediated...
- 12From: Nature Structural and Molecular Biology. (Vol. 16, Issue 7) Peer-ReviewedConstitutive heterochromatin in Arabidopsis thaliana is marked by repressive chromatin modifications, including DNA methylation, histone H3 dimethylation at Lys9 (H3K9me2) and monomethylation at Lys27 (H3K27me1 ). The...
- 13From: Nature Structural and Molecular Biology. (Vol. 16, Issue 7) Peer-ReviewedThe energetic contributions of hydrogen bonding to protein folding are still unclear, despite more than 70 years of study. This is due partly to the difficulty of extracting thermodynamic information about specific...
- 14From: Nature Structural and Molecular Biology. (Vol. 16, Issue 7) Peer-ReviewedDNA deaminases underpin pathways in antibody diversification (AID) and anti-viral immunity (APOBEC3s). Here we show how a high-throughput bacterial papillation assay can be used to screen for AID mutants with increased...
- 15From: Nature Structural and Molecular Biology. (Vol. 16, Issue 7) Peer-ReviewedOur central nervous system (CNS) is guarded by several layers of protection: the skull and vertebrae form a rigid shield and a special system of membranes (meninges) envelops the CNS, which is bathed in cerebrospinal...
- 16From: Nature Structural and Molecular Biology. (Vol. 16, Issue 7) Peer-Reviewed
The Hsp82 molecular chaperone promotes a switch between unextendable and extendable telomere states.
Distinct protein assemblies are nucleated at telomeric DNA to both guard the ends from damage and lengthen the DNA after replication. In yeast, Cdc13 recruits either Stn1-Ten1 to form a protective cap or the telomerase... - 17From: Nature Structural and Molecular Biology. (Vol. 16, Issue 7) Peer-ReviewedClostridium botulinum neurotoxins (BoNTs) cleave neuronal proteins responsible for neurotransmitter release, causing the neuroparalytic disease botulism. BoNT serotypes B, D, F and G cleave and inactivate...
- 18From: Nature Structural and Molecular Biology. (Vol. 16, Issue 7) Peer-ReviewedHistone modifications are central to the regulation of all DNA-dependent processes. Lys64 of histone H3 (H3K64) lies within the globular domain at a structurally important position. We identify trimethylation of H3K64...
- 19From: Nature Structural and Molecular Biology. (Vol. 16, Issue 7) Peer-ReviewedThe nuclear pore complex mediates nucleocytoplasmic transport in all eukaryotes and is among the largest cellular assemblies of proteins, collectively known as nucleoporins. Nucleoporins are organized into distinct...
- 20From: Nature Structural and Molecular Biology. (Vol. 16, Issue 7) Peer-ReviewedWhen targeting promoter regions, small interfering RNAs (siRNAs) trigger a previously proposed pathway known as transcriptional gene silencing by promoting heterochromatin formation. Here we show that siRNAs targeting...